Abstract: The invention relates to methods for treating tissue injury and/or afflictions, by administering a prophylactically or therapeutically effective amount of particulate, bioavailable ?(1-3;1-6) glucan. The invention also relates to methods in which ?(1-3;1-6) glucan is provided in the form of whole glucan particles, microparticulate ?-glucan particles or a combination thereof. The invention also relates to method of enhancing glucan-mediated committed stem cell proliferation and expansion after injury via the complement system.

Abstract: The present invention relates to methods of using whole glucan particles and complement activating antibodies for antitumor therapy. Whole glucan particles enhance the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. This binding enhances innate immune system cytotoxicity, as well as stimulating the release of activating cytokines.