Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.

Abstract: Systems and methods generate a 3D model of a surface of an object immersed in a transparent liquid within a stationary cylindrical transparent tank. First and second laser line projectors and a camera are rotated around a central axis of the cylindrical tank. The first and second laser line projectors each generate a laser line perpendicular to a plane or rotation and aligned with the center of rotation. The camera images the object. An image from the camera is captured at each of several angular positions of the camera relative to a reference position of the stationary cylindrical tank. The captured images are processed to determine, for each laser line within each image, a plurality of 3D positions where the laser line is incident upon a surface of the object. In embodiments, images are corrected with ray tracing or image warping and registration functions.

Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.

Abstract: A conductor of a power transmission line has its effective resistance to flow of direct current or low-frequency current (such as, for example, 50 Hz or 60 Hz) varied in a wide range to pass current and/or to generate heat for melting ice. Increasing the initial resistance of a conductor is accomplished by modulating the current at a high frequency (HF), such as about 1 kHz to about 100 kHz. The current through the conductor then becomes a mixture of a DC (or low-frequency current) and a high-frequency current. Because the latter flows in a thin skin-layer region of the conductor of depth dependent on frequency, the conductor's resistance to the HF current is higher than its resistance value for low frequency or DC current. By varying the frequency of current modulation in accordance with the present invention, the conductor's resistance is adjusted to a desired value for ice removal.

Abstract: The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.