Patents by Inventor Trygve Brautaset
Trygve Brautaset has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9322000Abstract: The present invention relates to a nucleic acid molecule, which encodes a polypeptide having alcohol dehydrogenase activity, in particular methanol dehydrogenase activity, comprising having a nucleotide sequence selected from the group consisting of: (i) a nucleotide sequence as set forth in any one of SEQ ID NOs: 1 (mdh2-MGA3), 3 (mdh3-MGA3), or 5 (mdh2-PB1); (ii) a nucleotide sequence having at least 90% sequence identity, more particularly at least 91, 92, 93, 94, 95, 96, 97, 98 or 99% sequence identity, with a nucleotide sequence as set forth in any one of SEQ ID NOs: 1, 3 or 5; (iii) a nucleotide sequence which is degenerate with any one of the nucleotide sequences of SEQ ID NOs: 1, 3 or 5; (iv) a nucleotide sequence which is a part of the nucleotide sequence of any one of SEQ ID NOs: 1, 3 or 5, or of a nucleotide sequence which is degenerate with a sequence of SEQ ID NOs: 1, 3 or 5; (v) a nucleotide sequence encoding all or part of a polypeptide whose amino acid sequence is set forth in any one of SEQ IType: GrantFiled: January 25, 2013Date of Patent: April 26, 2016Assignees: SINTEF TTO AS, ETH ZURICH, RIJKSUNIVERSITEIT GRONINGENInventors: Trygve Brautaset, Tonje Marita Bjerkan Heggeset, Anne Krog, Wilhelmus Johannes Quax, Mark Jan Jacobus Bernhard Sibbald, Julia Vorholt, Jonas Müller, Patrick Kiefer, Eva Potthoff, Volker F Wendisch, Lennart Lessmeier, Stéphanie Heux, Jean-Charles Portais
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Publication number: 20150267177Abstract: The present invention relates to a nucleic acid molecule, which encodes a polypeptide having alcohol dehydrogenase activity, in particular methanol dehydrogenase activity, comprising having a nucleotide sequence selected from the group consisting of: (i) a nucleotide sequence as set forth in any one of SEQ ID NOs: 1 (mdh2-MGA3), 3 (mdh3-MGA3), or 5 (mdh2-PB1); (ii) a nucleotide sequence having at least 90% sequence identity, more particularly at least 91, 92, 93, 94, 95, 96, 97, 98 or 99% sequence identity, with a nucleotide sequence as set forth in any one of SEQ ID NOs: 1, 3 or 5; (iii) a nucleotide sequence which is degenerate with any one of the nucleotide sequences of SEQ ID NOs: 1, 3 or 5; (iv) a nucleotide sequence which is a part of the nucleotide sequence of any one of SEQ ID NOs: 1, 3 or 5, or of a nucleotide sequence which is degenerate with a sequence of SEQ ID NOs: 1, 3 or 5; (v) a nucleotide sequence encoding all or part of a polypeptide whose amino acid sequence is set forth in any one of SEQ IType: ApplicationFiled: January 25, 2013Publication date: September 24, 2015Inventors: Trygve Brautaset, Tonje Marita Bjerkan Heggeset, Anne Krog, Wilhelmus Johannes Quax, Mark Jan Jacobus Bernhard Sibbald, Julia Vorholt, Jonas Mueller, Patrick Kiefer, Eva Potthoff, Volker F. Wendisch, Lennart Lessmeier, Stéphanie Heux, Jean-Charles Portais
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Patent number: 8859244Abstract: The present invention relates to a method of microbial production of L-lysine from methanol and other substrates, and particularly improving the production of L-lysine from such substrates. The invention concerns a method for producing L-lysine in B. methanolicus, said method comprising overexpressing an aspartate kinase III (AKIII) enzyme in said B. methanolicus. In particular the method may concern introducing a nucleic acid molecule comprising a nucleotide sequence encoding an AKIII enzyme into a B. methanolicus. The invention also relates to a B. methanolicus micro-organism which overexpresses an AKIII enzyme, nucleic acid molecules which encode polypeptides having AK activity, polypeptides which have AK activity and host cells and vector systems comprising the nucleic acid molecules or vector.Type: GrantFiled: May 15, 2009Date of Patent: October 14, 2014Assignee: Sinvent ASInventors: Trygve Brautaset, Øyvind Mejdell Jakobsen, Trond Ellingsen
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Publication number: 20140031534Abstract: The present invention provides a compound which is a nystatin derivative having an additional double bond present between C28 and C29 and which is further modified relative to nystatin at one or more of positions C5, C7, C9, C10, C11, C16 or at the amino group of mycosamine.Type: ApplicationFiled: March 8, 2013Publication date: January 30, 2014Applicant: BIOSERGEN ASInventors: Sergey Borisovich ZOTCHEV, Sven Even Finn BORGOS, Trygve BRAUTASET, Trond Erling ELLINGSEN, Evgenia Nikolaevna OLSUFYEVA, Maria Nikolaevna PREOBRAZHENSKAYA, Havard SLETTA
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Publication number: 20130130312Abstract: The present invention relates to a new strain of Micrococcus luteus, named Otnes7, which is superior to known strains in its ability to synthesise the carotenoid sarcinaxanthin and a method of producing sarcinaxanthin or a derivative thereof, said method comprising introducing into and expressing in a host cell one or more nucleic acid molecules encoding an activity in the sarcinaxanthin biosynthetic pathway.Type: ApplicationFiled: June 1, 2011Publication date: May 23, 2013Applicant: Promar ASInventors: Roman Netzer, Trygve Brautaset, Per Bruheim
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Patent number: 8415312Abstract: The present invention relates to compounds which are nystatin derivatives and are anti-fungal agents.Type: GrantFiled: June 30, 2008Date of Patent: April 9, 2013Assignee: Biosergen ASInventors: Sergey Borisovich Zotchev, Sven Even Finn Borgos, Trygve Brautaset, Trond Erling Ellingsen, Evgenia Nikolaevna Olsufyeva, Maria Nikolaevna Preobrazhenskaya, Havard Sletta
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Publication number: 20110177568Abstract: The present invention relates to a method of microbial production of L-lysine from methanol and other substrates, and particularly improving the production of L-lysine from such substrates. The invention concerns a method for producing lysine in B. methanolicus, said method comprising overexpressing an aspartate kinase III (AKIII) enzyme in said B. methanolicus. In particular the method may concern introducing a nucleic acid molecule comprising a nucleotide sequence encoding an AKIII enzyme into a B. methanolicus. The invention also relates to a B. methanolicus micro-organism which overexpresses an AKIII enzyme, nucleic acid molecules which encode polypeptides having AK activity, polypeptides which have AK activity and host cells and vector systems comprising the nucleic acid molecules or vector.Type: ApplicationFiled: May 20, 2009Publication date: July 21, 2011Inventors: Trygve Brautaset, Øyvind Mejdell Jakobsen, Trond Ellingsen
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Patent number: 7851183Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: GrantFiled: March 29, 2010Date of Patent: December 14, 2010Assignee: Sinvent ASInventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjærvik, Trygve Brautaset, Arne Reidar Strøm, Svein Valla, Trond Erling Ellingsen, Håvard Sletta, Ole-Martin Gulliksen
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Publication number: 20100286077Abstract: The present invention provides a compound of formula (I?) which is a nystatin derivative having an additional double bond present between C28 and C29 and which is further modified relative to nystatin at one or more of positions C5, C7, C9, C10, C11, C16 or at the amino group of mycosamine. These compounds are used as anti-fungal agents.Type: ApplicationFiled: June 30, 2008Publication date: November 11, 2010Inventors: Sergey Borisovich Zotchev, Sven Even Finn Borgos, Trygve Brautaset, Trond Erling Ellingsen, Evgenia Nikolaevna Olsufyeva, Maria Nikolaevna Preobrazhenskaya, Havard Sletta
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Publication number: 20100216870Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: ApplicationFiled: March 29, 2010Publication date: August 26, 2010Applicant: SINVENT ASInventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjaervik, Trygve Brautaset, Arne Reidar Strom, Svein Valla, Trond Erling Ellingsen, Håvard Sletta, Ole-Martin Gulliksen
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Patent number: 7709231Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: GrantFiled: September 11, 2006Date of Patent: May 4, 2010Assignee: Sinvent ASInventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjærvik, Trygve Brautaset, Arne Reidar Strøm, Svein Valla, Trond Erling Ellingsen, Håvard Sletta, Ole-Martin Gulliksen
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Publication number: 20080119541Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: ApplicationFiled: September 11, 2006Publication date: May 22, 2008Applicant: Sinvent ASInventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjaervik, Trygve Brautaset, Arne Reidar Strom, Svein Valla, Trond Erling Ellingsen, Havard Sletta, Ole-Martin Gulliksen
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Patent number: 7141660Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: GrantFiled: February 8, 2001Date of Patent: November 28, 2006Assignee: Sinvent ASInventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjaervik, Trygve Brautaset, Arne Reidar Strøm, Svein Valla, Trond Erling Ellingsen, Hävard Sletta, Ole-Martin Gulliksen
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Publication number: 20040115762Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: ApplicationFiled: February 7, 2003Publication date: June 17, 2004Inventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjaervik, Trygve Brautaset, Arne Reidar Strom, Svein Valla, Trond Erling Ellingsen, Havard Sletta, Ole-Martin Gulliksen