Patents by Inventor Tsai-Miao Shih

Tsai-Miao Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11793823
    Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt thereof, in which Ring X is a 3 to 7 membered monocyclic ring, at least one of R1, R2, R3, and R4 is OR5 or CH2OR5 and the other R1, R2, R3, and R4 each independently are halogen, OH, OR5, CH2OR5, CO2H, OC?OR6, (C?O)R6, R6, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, H, or absent. Also provided herein are therapeutic uses of the compound of Formula (I).
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: October 24, 2023
    Assignee: SyneuRx International (Taiwan) Corp.
    Inventors: Guochuan Emil Tsai, Yi-Wen Mao, Lu-Ping Lu, Wei-Hua Chang, Han-Yi Hsieh, Jhe Wei Hu, Tsai-Miao Shih, ChanHui Huang
  • Patent number: 11779561
    Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 1, 2022
    Date of Patent: October 10, 2023
    Assignee: SyneuRx International (Taiwan) Corp.
    Inventors: Guochuan Emil Tsai, Yi-Wen Mao, Lu-Ping Lu, Wei-Hua Chang, Han-Yi Hsieh, Jhe Wei Hu, Tsai-Miao Shih, ChanHui Huang
  • Publication number: 20220218730
    Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt thereof, in which Ring X is a 3 to 7 membered monocyclic ring, at least one of R1, R2, R3, and R4 is OR5 or CH2OR5 and the other R1, R2, R3, and R4 each independently are halogen, OH, OR5, CH2OR5, CO2H, OC?OR6, (C?O)R6, R6, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, H, or absent. Also provided herein are therapeutic uses of the compound of Formula (I).
    Type: Application
    Filed: March 21, 2022
    Publication date: July 14, 2022
    Inventors: Guochuan Emil Tsai, Yi-Wen Mao, Lu-Ping Lu, Wei-Hua Chang, Han-Yi Hsieh, Jhe Wei Hu, Tsai-Miao Shih, ChanHui Huang
  • Patent number: 11382924
    Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: July 12, 2022
    Assignee: SyneuRx International (Taiwan) Corp.
    Inventors: Guochuan Emil Tsai, Yi-Wen Mao, Lu-Ping Lu, Wei-Hua Chang, Han-Yi Hsieh, Jhe Wei Hu, Tsai-Miao Shih, ChanHui Huang
  • Publication number: 20220152069
    Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 1, 2022
    Publication date: May 19, 2022
    Applicant: SyneuRx International (Taiwan) Corp.
    Inventors: Guochuan Emil Tsai, Yi-Wen Mao, Lu-Ping Lu, Wei-Hua Chang, Han-Yi Hsieh, Jhe Wei Hu, Tsai-Miao Shih, ChanHui Huang
  • Publication number: 20220054516
    Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 16, 2021
    Publication date: February 24, 2022
    Inventors: Guochuan Emil Tsai, Yi-Wen Mao, Lu-Ping Lu, Wei-Hua Chang, Han-Yi Hsieh, Jhe Wei Hu, Tsai-Miao Shih, ChanHui Huang
  • Publication number: 20220047561
    Abstract: Provided herein is salts of formula [A][B], wherein [A] is a cation form of a cycloserine compound and [B] is an anion form of a compound of Formula (I), wherein the ratio between the cycloserine compound and the compound of formula (I) ranges from 10:1 to 1:10. The salts described herein have improved properties, including greatly increased stability and decreased hygroscopicity. Also provided herein are methods for treating and/or reducing the risk of a neuropsychiatric disorder and/or a bacterial infectious disease (e.g., tuberculosis), comprising administering a subject in need a composition comprising salts of formula [A][B] described herein.
    Type: Application
    Filed: September 12, 2019
    Publication date: February 17, 2022
    Applicant: SyneuRx International (Taiwan) Corp.
    Inventors: Guochuan Emil Tsai, Ching-Cheng Wang, Tsai-Miao Shih
  • Patent number: 11154531
    Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: October 26, 2021
    Assignee: SYNEURX INTERNATIONAL (TAIWAN) CORP.
    Inventors: Guochuan Emil Tsai, Yi-Wen Mao, Lu-Ping Lu, Wei-Hua Chang, Han-Yi Hsieh, Jhe Wei Hu, Tsai-Miao Shih, ChanHui Huang
  • Publication number: 20210251945
    Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 8, 2020
    Publication date: August 19, 2021
    Inventors: Guochuan Emil Tsai, Yi-Wen Mao, Lu-Ping Lu, Wei-Hua Chang, Han-Yi Hsieh, Jhe Wei Hu, Tsai-Miao Shih, ChanHui Huang
  • Patent number: 10485790
    Abstract: The present invention relates to salts of formula [A][B], wherein [A] is a cation form of a cycloserine compound and [B] is an anion form of a compound of Formula (I): wherein the ratio between the cycloserine compound and the compound of formula (I) ranges from 10:1 to 1:10. The salts described herein have improved properties, including greatly increased stability and decreased hygroscopicity. Also provided in the present invention are methods for treating and/or reducing the risk of a neuropsychiatric disorder and/or a bacterial infectious disease (e.g., tuberculosis), comprising administering a subject in need a composition comprising salts of formula [A][B] described herein.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: November 26, 2019
    Assignee: SyneuRx International (Taiwan) Corp.
    Inventors: Guochuan Emil Tsai, Ching-Cheng Wang, Tsai-Miao Shih