Patents by Inventor TSAI-YIN WEI

TSAI-YIN WEI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND ANTIBODIES FOR MODULATION OF IMMUNORESPONSE
    Publication number: 20240002515
    Abstract: Provided are an anti-CD11b antibody or an antigen-binding portion thereof, and methods and use of the antibody for modulating immunoresponses by regulating CD11b expression on cells.
    Type: Application
    Filed: May 18, 2023
    Publication date: January 4, 2024
    Applicant: Ascendo Biotechnology, Inc.
    Inventors: Yen-Ta Lu, Chia-Ming Chang, Tsai-Yin Wei, I-Fang Tsai, Ling-Chiao Wu
  • Methods and antibodies for modulation of immunoresponse
    Patent number: 11685785
    Abstract: A method for reversing immune suppression or immune exhaustion or for treating a disease associated with immune suppression includes: administering a composition to a subject in need of such treatments, wherein the composition contains a CD11b modulator that binds specifically to CD11b on a cell to inhibit PD-L1 expression. The CD11b modulator is an antibody or an antigen-binding portion thereof, or a compound as described.
    Type: Grant
    Filed: June 12, 2016
    Date of Patent: June 27, 2023
    Assignee: Ascendo Biotechnology, Inc.
    Inventors: Yen-Ta Lu, Chia-Ming Chang, Tsai-Yin Wei, I-Fang Tsai, Ling-Chiao Wu
  • BENZO-HETEROCYCLIC COMPOUNDS AND THEIR APPLICATIONS
    Publication number: 20200339557
    Abstract: The present invention relates to benzoxazole derivatives having the following Formula (I): The compounds of the present invention are found to possess the ability to decrease PD-L1 level, suggesting that the compounds of the invention can be used in cancer immunotherapy and treatment or prevention of sepsis or septic shock.
    Type: Application
    Filed: July 9, 2020
    Publication date: October 29, 2020
    Applicant: MACKAY MEDICAL FOUNDATION THE PRESBYTERIAN CHURCH IN TAIWAN MACKAY MEMORIAL HOSPITAL
    Inventors: Yen-Ta LU, Tzenge-Lien SHIH, Chia-Ming CHANG, Tsai-Yin WEI, Jen-Wei LIU
  • METHODS AND ANTIBODIES FOR MODULATION OF IMMUNORESPONSE
    Publication number: 20180362651
    Abstract: A method fits reversing immune suppression or immune exhaustion or for treating a disease associated with immune suppression includes: administering a co position to a subject in need of such treatments wherein the composition contains a CD11b modulator that binds specifically to CD11b on a cell to inhibit PD-L1 expression. The CD11b modulator is an antibody or an antigen-binding portion thereof, or a compound as described.
    Type: Application
    Filed: June 12, 2016
    Publication date: December 20, 2018
    Applicant: Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital
    Inventors: Yen-Ta LU, Chia-Ming CHANG, Tsai-Yin WEI, I-Fang TSAI, Ling-Chiao WU
  • METHODS AND POLYPEPTIDES FOR MODULATION OF IMMUNORESPONSE
    Publication number: 20180141991
    Abstract: A method for modulating an immunoresponse includes binding a TREM-like transcript 1 (TLT-1) polypeptide to an immune cell, wherein the binding of the TLT-1 polypeptide to the immune cell suppresses immunoresponse. A method for treating and/or preventing a disease associated with immune hyper-reactivity includes administering the TLT-1 polypeptide to a subject in need thereof.
    Type: Application
    Filed: June 12, 2016
    Publication date: May 24, 2018
    Applicant: Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital
    Inventors: Yen-Ta LU, Chia-Ming CHANG, Tsai-Yin WEI
  • BENZO-HETEROCYCLIC COMPOUNDS AND THEIR APPLICATIONS
    Publication number: 20170283408
    Abstract: The present invention relates to benzoxazole derivatives having the following Formula (I): The compounds of the present invention are found to possess the ability to decrease PD-L1 level, suggesting that the compounds of the invention can be used in cancer immunotherapy and treatment or prevention of sepsis or septic shock.
    Type: Application
    Filed: September 17, 2015
    Publication date: October 5, 2017
    Inventors: YEN-TA LU, TZENGE-LIEN SHIH, CHIA-MING CHANG, TSAI-YIN WEI, JEN-WEI LIU