Patents by Inventor Tsai-Yueh Luo
Tsai-Yueh Luo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11654203Abstract: Disclosed herein are a dual-targeted carbonic anhydrase IX complex, a contrast agent comprising the same, and a synthesizing method thereof. The dual-targeted carbonic anhydrase IX complex includes a carbonic anhydrase IX (CA9) binding peptide, a sulfonamide derivative, and a metal chelating agent. The dual-targeted carbonic anhydrase IX complex has potential for use as a molecular nuclear drug.Type: GrantFiled: October 26, 2020Date of Patent: May 23, 2023Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.CInventors: Siao-Syun Guan, Tsai-Yueh Luo, Tse-Zung Liao, Cheng-Liang Peng, Kun-Liang Lin
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Patent number: 11247947Abstract: A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. An isolation process of non-toxic radio-high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with an alumina solid-phase column in advance to obtain the crude product while fluorine-18 is removed. Then, diphenyl semipreparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction yield about 50 percent (%). The method has an uncorrected radiochemical yield of 10˜20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.Type: GrantFiled: January 4, 2021Date of Patent: February 15, 2022Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.Inventors: Yean-Hung Tu, Li-Yuan Huang, Jenn-Tzong Chen, Tsai-Yueh Luo, Shiou-Shiow Farn, Wuu-Jyh Lin
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Patent number: 11191718Abstract: The present invention provides an ophthalmic gel and a preparation method thereof. The ophthalmic gel comprises: an antibiotic; a nanocarrier, wherein the nanocarrier is used to load the antibiotic; and a biodegradable matrix, wherein the biodegradable matrix is compatible with the nanocarrier to carry the nanocarrier. When the ophthalmic gel of the present invention is applied to the surface of the cornea and conjunctiva of the eyes, the biodegradable matrix is automatically degraded and the nanocarrier carried by the biodegradable matrix will slowly release the antibiotic, loaded in the nanocarrier, at an appropriate rate to overcome the high-frequency use of general ophthalmic drugs and easily caused blurred vision; the present invention further comprises an ophthalmic gel preparation method.Type: GrantFiled: August 13, 2019Date of Patent: December 7, 2021Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.CInventors: Ming-Cheng Chang, Tsai-Yueh Luo, Cheng-Liang Peng, Kuan-Yin Chen
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Publication number: 20210154334Abstract: Disclosed herein are a dual-targeted carbonic anhydrase IX complex, a contrast agent comprising the same, and a synthesizing method thereof. The dual-targeted carbonic anhydrase IX complex includes a carbonic anhydrase IX (CA9) binding peptide, a sulfonamide derivative, and a metal chelating agent. The dual-targeted carbonic anhydrase IX complex has potential for use as a molecular nuclear drug.Type: ApplicationFiled: October 26, 2020Publication date: May 27, 2021Inventors: SIAO-SYUN GUAN, TSAI-YUEH LUO, TSE-ZUNG LIAO, CHENG-LIANG PENG, KUN-LIANG LIN
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Publication number: 20210147315Abstract: A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. An isolation process of non-toxic radio-high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with an alumina solid-phase column in advance to obtain the crude product while fluorine-18 is removed. Then, diphenyl semipreparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction yield about 50 percent (%). The method has an uncorrected radiochemical yield of 10˜20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.Type: ApplicationFiled: January 4, 2021Publication date: May 20, 2021Inventors: Yean-Hung Tu, Li-Yuan Huang, Jenn-Tzong Chen, Tsai-Yueh Luo, Shiou-Shiow Farn, Wuu-Jyh Lin
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Publication number: 20200345631Abstract: The present invention provides an ophthalmic gel and a preparation method thereof. The ophthalmic gel comprises: an antibiotic; a nanocarrier, wherein the nanocarrier is used to load the antibiotic; and a biodegradable matrix, wherein the biodegradable matrix is compatible with the nanocarrier to carry the nanocarrier. When the ophthalmic gel of the present invention is applied to the surface of the cornea and conjunctiva of the eyes, the biodegradable matrix is automatically degraded and the nanocarrier carried by the biodegradable matrix will slowly release the antibiotic, loaded in the nanocarrier, at an appropriate rate to overcome the high-frequency use of general ophthalmic drugs and easily caused blurred vision; the present invention further comprises an ophthalmic gel preparation method.Type: ApplicationFiled: August 13, 2019Publication date: November 5, 2020Inventors: Ming-Cheng Chang, Tsai-Yueh Luo, Cheng-Liang Peng, Kuan-Yin Chen
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Publication number: 20200239409Abstract: A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. An isolation process of non-toxic radio-high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with an alumina solid-phase column in advance to obtain the crude product while fluorine-18 is removed. Then, diphenyl semipreparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction yield about 50 percent (%). The method has an uncorrected radiochemical yield of 10˜20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.Type: ApplicationFiled: January 30, 2019Publication date: July 30, 2020Inventors: Yean-Hung Tu, Li-Yuan Huang, Jenn-Tzong Chen, Tsai-Yueh Luo, Shiou-Shiow Farn, Wuu-Jyh Lin
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Publication number: 20190224349Abstract: The present invention relates to a preparation method of a carrier containing a radiolabeled colloid, which comprises the following steps: adsorption: putting a carrier into a radioisotope water solution, and reacting for 5-20 minutes to obtain a first solution; coating: adding a solvent capable of enabling a colloid to be formed into the first solution, and reacting for 5-20 minutes to obtain a second solution; and purification: centrifuging the second solution to form a first supernatant and a first precipitate, removing the first supernatant, cleaning the first precipitate with deionized water, centrifuging to form a second supernatant and a second precipitate, and finally, removing the second supernatant, wherein the residual second precipitate is the carrier containing the radiolabeled colloid.Type: ApplicationFiled: June 19, 2018Publication date: July 25, 2019Inventors: Ying-Hsia Shih, Tsai-Yueh Luo, Cheng-Liang Peng
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Publication number: 20190117574Abstract: A surface-modified microsphere composition comprises poly(lactic-co-glycolic acid) (PLGA), chitosan, hydrophobic drug, and hydrophilic drug. The PLGA forms a microsphere. The chitosan is formed on a surface of the microsphere. The hydrophobic drug is encapsulated by the microsphere. The hydrophilic drug is adsorbed on the surface of the microsphere. The surface-modified microsphere composition is for treating arthritis. A method of preparing a surface-modified microsphere composition involves producing by an oil-in-water emulsion method microspheres formed from PLGA, covered with chitosan, and adapted to encapsulate hydrophobic drug, and having hydrophilic drug adsorbed on their surfaces. The surface-modified microsphere composition enables drug to be released to achieve efficacy both instantly and persistently.Type: ApplicationFiled: October 20, 2017Publication date: April 25, 2019Inventors: YU-WEI YEN, TSAI-YUEH LUO, CHENG-LIANG PENG, PING-FANG CHIANG
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Publication number: 20190071429Abstract: Disclosed herein are a multi-functional probe and uses thereof. The multi-functional probe has a main structure represented by chemical Formula (1), and is configured to diagnose and treat the cancers.Type: ApplicationFiled: May 24, 2018Publication date: March 7, 2019Inventors: Cheng-Liang PENG, Tsai-Yueh LUO, Ying-Hsia SHIH
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Patent number: 9775920Abstract: The present invention relates to a novel use of N-(4-isopropylphenyl)-5-amino-isoindoline for diagnosing Alzheimer's disease and quantifying amyloid in the brain.Type: GrantFiled: July 29, 2016Date of Patent: October 3, 2017Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.Inventors: Wan-I Kuo, Jian-Hua Zhao, Kang-Wei Chang, Tsai-Yueh Luo, Wei-Hsi Chen
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Publication number: 20170028087Abstract: The present invention relates to a novel use of N-(4-isopropylphenyl)-5-amino-isoindoline for diagnosing Alzheimer's disease and quantifying amyloid in the brain.Type: ApplicationFiled: July 29, 2016Publication date: February 2, 2017Inventors: WAN-I KUO, JIAN-HUA ZHAO, KANG-WEI CHANG, TSAI-YUEH LUO, WEI-HSI CHEN
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Publication number: 20160339358Abstract: A manufacturing and separating device and a method for oily radioactive substances provide an automatic synthesis box to minimize the man-made errors during the manufacturing, such that mass production for the oily radioactive substance can be possible, the radiation exposure time of the manufacturing staff can be reduced, and the radioactivity of the final products can be detected. The manufacturing and separating device includes a first reaction material bottle, a first heating device, a gas pump, a first flushing material bottle, a second flushing material bottle, a purifying device, a first transmission unit, a temperature-controlled temporary storage tank, a filter, a first collection bottle, a second collection bottle, a plurality of valves and a control unit.Type: ApplicationFiled: May 6, 2016Publication date: November 24, 2016Inventors: CHIH-CHING WANG, TSAI-YUEH LUO, I-CHUNG TANG
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Publication number: 20160287723Abstract: Albumin and doxorubicin are bonded through reaction. The bonded albumin and doxorubicin are added with a gold-nanoparticles solution for reaction. After being purified with water in a column, the liquid phase of gold-nanoparticles is changed into a phosphate buffer for obtaining an anticancer drug having doxorubicin bonded with gold nanoparticles. Thus, with the high biocompatibility and the big surface areas, gold nanoparticles are used in biological applications and used as carriers for increasing drug accumulation on tumor. The bonding between gold nanoparticles and doxorubicin increases stability of doxorubicin. Besides, doxorubicin has tumor-killing effect for cancer therapy.Type: ApplicationFiled: March 30, 2015Publication date: October 6, 2016Inventors: Chun-Chia Cheng, Tsai-Yueh Luo
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Patent number: 9221029Abstract: The present invention relates to an automatic system for synthesizing iodine-123 meta-iodobenzylguanidine (123I-MIBG), which comprises a first reactor for subjecting radioactive iodine-containing sodium iodide and meta-iodobenzylguanidine (MIBG) sulfate to an iodine-iodine exchange reaction to obtain radioactive iodine labeled MIBG; a purification unit for purifying the iodine labeled MIBG; and a second reactor for substituting a solvent used in purification with a phosphate buffer to obtain a phosphate solution containing 123I-MIBG. The present invention also relates to an automatic device for dispensing 123I-MIBG, which comprises the automatic system for synthesizing 123I-MIBG, a radioactivity measuring unit, and a dispensing and packing unit.Type: GrantFiled: August 20, 2014Date of Patent: December 29, 2015Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUANInventors: Tsai-Yueh Luo, Te-Sheng Liang, Ying-Hsia Shih, Wuu-Jyh Lin
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Publication number: 20150104380Abstract: The present invention relates to a biodegradable carrier for carrying a radioisotope, which is formed from at least one biodegradable polymer selected from the group consisting of poly(lactic-co-glycolic acid) (PLGA), poly(lactic acid) (PLA), poly(?-caprolactone) (PCL), chitosan, poly(?-glutamic acid) (PGA), and polyethylene glycol (PE) in which its hydroxyl group is substituted with an amino group and grafted with tetraazocyclododecanetetraacetic acid monosuccinimide ester (DOTA-NHS), in which nitrogen atoms contained in the DOTA-NHS are provided for coordinating with a radioisotope. The present invention also relates to a kit which includes a first container containing the biodegradable carrier for carrying a radioisotope according to the present invention and a second container containing a radioisotope.Type: ApplicationFiled: July 18, 2014Publication date: April 16, 2015Inventors: LIANG-YU CHANG, TSAI-YUEH LUO, MIN-SHENG PU, PING-FANG CHIANG, HUA-MIN WANG, YING-HSIA SHIH
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Publication number: 20150056105Abstract: The present invention relates to an automatic system for synthesizing iodine-123 meta-iodobenzylguanidine (123I-MIBG), which comprises a first reactor for subjecting radioactive iodine-containing sodium iodide and meta-iodobenzylguanidine (MIBG) sulfate to an iodine-iodine exchange reaction to obtain radioactive iodine labeled MIBG; a purification unit for purifying the iodine labeled MIBG; and a second reactor for substituting a solvent used in purification with a phosphate buffer to obtain a phosphate solution containing 123I-MIBG. The present invention also relates to an automatic device for dispensing 123I-MIBG, which comprises the automatic system for synthesizing 123I-MIBG, a radioactivity measuring unit, and a dispensing and packing unit.Type: ApplicationFiled: August 20, 2014Publication date: February 26, 2015Inventors: Tsai-Yueh LUO, Te-Sheng LIANG, Ying-Hsia SHIH, Wuu-Jyh LIN
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Publication number: 20130336889Abstract: A nanoparticle for detecting or treating a tumor is provided. The nanoparticle includes a plurality of polymer backbones and at least one first detectable substance, of which each of the polymer backbones includes a hydrophobic region, a hydrophilic region and a chelating region, and the first detectable substance is bound to the chelating region of the polymer backbone. The hydrophobic regions of the polymer backbones form a core block, and the hydrophilic regions of the polymer backbones form a shell block surrounding the core block. A method for detecting or treating a tumor using the nanoparticle is also provided.Type: ApplicationFiled: June 14, 2012Publication date: December 19, 2013Applicant: NATIONAL TAIWAN UNIVERSITYInventors: Ming-Jium Shieh, Cheng-Liang Peng, Tsai-Yueh Luo
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Publication number: 20130266508Abstract: A thermosensitive hydrogel for coating radioisotopes and chemotherapeutic agents to treat cancer and a method for preparing the same are revealed. The anticancer drugs such as radiopharmaceuticals or chemotherapeutic agents are coated with the hydrogel formed by PCL-PEG-PCL. By the feature of the hydrogel body that changes from liquid phase at low storage temperature to gel form at body temperature, not only the anticancer drugs can be injected into the human body and reaching the treatment site smoothly but the treatment time of brachytherapy is also extended. Thus the side effects of cancer therapy are significantly reduced.Type: ApplicationFiled: April 9, 2012Publication date: October 10, 2013Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCHInventors: Tsai-Yueh Luo, Cheng-Liang Peng, Ming-Jium Shieh, Ying-Hsia Shih, Chung-Hsin Yeh, I-Chung Tang
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Patent number: 8367811Abstract: A radioactive material containing chitosan for inhibiting cancer and a preparation method thereof are revealed. The adioactive material containing chitosan is formed by using SOCTA chelating agent to connect chitosan and radionuclides such as 188Re, and Tc-99m etc. The preparation method of the radioactive material containing chitosan includes the steps of: prepare SOCTA-Chitosan compound; and prepare M(radionuclide)-SOCTA-Chitosan compound. By biocompatibility and clotting in alkaline environment of human blood of chitosan, the radioactive material containing chitosan is injected into cancer and staying there for a long time so as to achieve effectively treatment.Type: GrantFiled: November 3, 2008Date of Patent: February 5, 2013Assignee: Atomic Energy Council-Institute of Nuclear Energy ResearchInventors: Tsai-Yueh Luo, I-Chung Tang, Jian-Wen Chen, Kwei-Luen Hsu, Yu-Lung Wu, Te-Sheng Liang, Chang-Mau Sheng, Jin-Jenn Lin, Ching-Jun Liou, Jyh-Daw Sheu