Patents by Inventor Tsang-Lin HWANG

Tsang-Lin HWANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHYLATION OF MCL-1 COMPOUNDS
    Publication number: 20230117777
    Abstract: Disclosed herein is an improved process for the synthesis of compound (A): (A), or a salt or solvate thereof via methylation of compound (B): (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound (A).
    Type: Application
    Filed: March 30, 2021
    Publication date: April 20, 2023
    Applicant: AMGEN INC.
    Inventors: Michal ACHMATOWICZ, Sheng CUI, Tsang-Lin HWANG, Neil Fred LANGILLE, Janine K. TOM, James E. HUCKLE, Markian STEC, Tian WU, Sean P. BROWN
  • METHODS OF FINGERPRINTING THERAPEUTIC PROTEINS VIA A TWO-DIMENSIONAL (2D) NUCLEAR MAGNETIC RESONANCE TECHNIQUE AT NATURAL ABUNDANCE FOR FORMULATED BIOPHARMACEUTICAL PRODUCTS
    Publication number: 20220187398
    Abstract: Methods of fingerprinting a specific molecule in a composition using nuclear magnetic resonance (NMR) is disclosed. The disclosed NMR methods provide several modifications and improvements over existing NMR techniques. In some embodiments, the methods include applying a cycle of signal processing steps, including applying a radio frequency (RF) pulse, applying a gradient pulse having a pulse length less than or equal to 1000 ?s, and applying a water suppression technique (WET). In some embodiments, the methods further include repeating the cycle for at least 3 times to acquire an enhanced signal of the composition.
    Type: Application
    Filed: March 26, 2020
    Publication date: June 16, 2022
    Applicant: AMGEN INC.
    Inventors: Tsang-Lin HWANG, Mats H. WIKSTROEM