Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: A method of controlling a water-pump of an air conditioning system used in an active air conditioning water circulating system includes: detecting an environmental parameter and a load value of the active air conditioning water system actively; adjusting a flow rate of a water-pump of the active air conditioning water system according to a first control logic when the environmental parameter is less than a first pre-default parameter and the load value is less than a load threshold; and, adjusting the flow rate of the water-pump according to a first control logic when the environmental parameter is not less than the first pre-default parameter or the load value is not less than the load threshold. The present disclosed example can enhance a flow control capacity for different environmental statuses via controlling the flow rate in the different environmental status according to the different control logic.

Abstract: The present disclosure relates to a performance forecasting method applied to an air conditioning equipment and a central server. The air conditioning equipment has a plurality of detecting elements so as to detect a plurality kinds of physical parameters and a performance parameter. The central server stores those parameters as a set of first parameters and a first performance value. When the central server receives other physical parameters and another performance parameter, it calculates the similarity between the other physical parameters and each set of the first parameters according to the law of cosines. The central server selects the set of the first parameters which have the similarity being greater than a selecting threshold, so as to calculating an expected performance value. Accordingly, the central server can forecast a performance decline degree by comparing the another performance parameter and the expected performance value.

Abstract: The invention pertains to the creation of two new classes of compounds, referred to as “phenyl, bromo-maleimide acids” and “Phenyl, bromo-maleimide amines”, which are derivatized from the maleimide, C2H2(CO)2NH (2,5-pyrroledione) and have the backbone structure of formula I and II below, where n is 0-6. In the maleimide ring, a hydrogen in the 3,4-imide (C2H2) is substituted by a bromide and the nitrogen is bonded to a phenyl group, which is bonded to a carboxylic acid or amine. The invention also pertains to the use of these two classes of compounds to tag molecules with a Br,Ph-maleimide group or to synthesize hetrobifunctional linkers with a Br,Ph-maleimide group for conjugating various molecules to the sulfhydryl groups of cysteine residues in proteins, peptides, nanoparticles, or cells.

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: An adjusting system includes a system optimization device, a central control device, at least one air conditioning load device, at least one indoor area environment sensing device, and at least one outdoor area external environment sensing device. The at least one air conditioning load device is configured to obtain an air conditioning load parameter according to an air conditioning load in the space area. The at least one indoor area environment sensing device is configured to obtain an indoor environment parameter. The at least one outdoor area external environment sensing device is configured to obtain an outdoor environment parameter. The system optimization device receives the indoor environment parameter, the outdoor environment parameter, and the air conditioning load parameter and calculates to obtain a control parameter. The central control device controls the supply temperature of the water chiller according to the control parameter.

Abstract: The present disclosure provides various core constructs. According to embodiments of the present disclosure, the core construct can be used to configure pharmaceutical molecules. In particular, the core construct may be conjugated with a functional element via the click chemistry.

Abstract: The present disclosure provides various linker units and molecular constructs, each of which has a targeting element and an effector element linked therewith. Methods for treating various diseases using such linker units and molecular constructs are also disclosed.

Abstract: A method of controlling a water-pump of an air conditioning system used in an active air conditioning water circulating system includes: detecting an environmental parameter and a load value of the active air conditioning water system actively; adjusting a flow rate of a water-pump of the active air conditioning water system according to a first control logic when the environmental parameter is less than a first pre-default parameter and the load value is less than a load threshold; and, adjusting the flow rate of the water-pump according to a first control logic when the environmental parameter is not less than the first pre-default parameter or the load value is not less than the load threshold. The present disclosed example can enhance a flow control capacity for different environmental statuses via controlling the flow rate in the different environmental status according to the different control logic.

Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: The present disclosure provides various molecular constructs having a targeting element and/or an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Abstract: Disclosed herein are linker units comprising a center core, a plurality of linking arms, and optionally, a coupling arm. According to the embodiments of the present disclosure, the present linker units further comprises a targeting element and an effector element. Also disclosed herein are methods for treating various diseases using such linker units.