Patents by Inventor Tse Ying Liu

Tse Ying Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210038876
    Abstract: An implantable ultrasound conducting and drug delivering apparatus includes a drug-accommodating member and a shell-shaped ultrasound-scattering member mounted on a bottom of the drug-accommodating member. The shell-shaped ultrasound-scattering member thereon has a plurality of scattering through-holes. The drug-accommodating member has at least one linking through-hole formed on the bottom thereof to communicate the bottom of the drug-accommodating member with the shell-shaped ultrasound-scattering member. The shell-shaped ultrasound-scattering member is fitted to be disposed within a physical cavity of a patient. A drug is injected into an accommodating room of the drug-accommodating member. The drug passes through the scattering through-holes and delivers to the physical cavity.
    Type: Application
    Filed: July 2, 2018
    Publication date: February 11, 2021
    Inventor: Tse-Ying LIU
  • Patent number: 10773098
    Abstract: The invention provides a therapy method for glioblastoma multiforme (GBM). The therapy method uses a low-dose radiation to realize GBM tumor cell-targeted radiotherapy via sequentially administration of radiation enhancer-incorporated nanocarriers, 5-aminolevulinic acid, therapeutic ultrasound and therapeutic radiation.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: September 15, 2020
    Assignee: National Yang-Ming University
    Inventors: Tse-Ying Liu, Ming-Hong Chen
  • Publication number: 20180207447
    Abstract: The invention provides a therapy method for glioblastoma multiforme (GBM). The therapy method uses a low-dose radiation to realize GBM tumor cell-targeted radiotherapy via sequentially administration of radiation enhancer-incorporated nanocarriers, 5-aminolevulinic acid, therapeutic ultrasound and therapeutic radiation.
    Type: Application
    Filed: January 23, 2018
    Publication date: July 26, 2018
    Inventors: Tse-Ying LIU, Ming-Hong CHEN
  • Patent number: 9220777
    Abstract: Present invention relates to an ultrasonically-triggered drug vehicle with magnetic resonance imaging function. In the delivery system of the invention, tracks the of drug vehicle carrying a certain drug (or drugs) is detectable by magnetic resonance imaging, and the release of drug is triggered by ultrasonication when the drug vehicle arrives at target site and accumulates to a desirable concentration. The MRI-guided drug delivery system provides improved accuracy of drug releasing, including position and timing.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: December 29, 2015
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventor: Tse-Ying Liu
  • Publication number: 20140212502
    Abstract: The present invention relates to a novel nano-/micro-bubble drug vehicle with functions of carrying hydrophobic drugs, ultrasound-triggered release and magnetic resonance or optical imaging, made of amphiphilic chitosan polymer material, and lipophlic superparamagnetic iron oxide (SPIO) or luminous nanoparticles. By using magnetic resonance or optical imaging to track the location of the drug vehicle, a user can trigger the release of drug by ultrasonication when the drug vehicle arrives at target site and accumulates to a desirable concentration. The nano-/micro-bubble drug delivery system provides improved accuracy of drug releasing, including position and timing, and thus reduces side effects of the drug. In addition, the synergistic effect of the amphiphilic chitosan molecules and sonication may improve the transmembrane delivery of hydrophobic agent into target cell, and enhance the cytotoxicity of anti-cancer drugs.
    Type: Application
    Filed: July 31, 2013
    Publication date: July 31, 2014
    Applicant: NATIONAL YANG-MING UNIVERSITY
    Inventor: Tse-Ying LIU
  • Publication number: 20130204181
    Abstract: Present invention relates to a dual-modal imaging (magnetic resonance and ultrasound)-guided drug vehicle and system, which possess encapsulation of hydrophobic drug and ultrasound-triggered release function. In the delivery system of the invention, the drug vehicle carrying certain drug (or drugs) is detectable by magnetic resonance imaging, and the release of drug is triggered by ultrasonication when the drug vehicle arrives at target site and accumulates to a desirable concentration. The MRI-guided drug delivery system provides improved accuracy of drug releasing, including position and timing.
    Type: Application
    Filed: July 11, 2012
    Publication date: August 8, 2013
    Inventor: Tse-Ying LIU
  • Publication number: 20120045397
    Abstract: Present invention relates to an ultrasonically-triggered drug vehicle with magnetic resonance imaging function. In the delivery system of the invention, tracks the of drug vehicle carrying a certain drug (or drugs) is detectable by magnetic resonance imaging, and the release of drug is triggered by ultrasonication when the drug vehicle arrives at target site and accumulates to a desirable concentration. The MRI-guided drug delivery system provides improved accuracy of drug releasing, including position and timing.
    Type: Application
    Filed: October 20, 2010
    Publication date: February 23, 2012
    Inventor: Tse-Ying Liu
  • Publication number: 20040083604
    Abstract: A pin lamination method that may eliminate pits and dents formed in a multi-layer printed wiring board, includes the steps of: (a) preparing steel plates and coppers in a clean working room, and preparing prepregs and cores in a working room; (b) laminating a first copper having a shiny surface facing upward, a steel plate, and a second copper having a shiny surface facing downward, thereby forming a sandwiched lamination board, with the steel plate sandwiched between the first and second coppers, wherein the shiny surface of each of the first and second coppers is directed toward the steel plate; and (c) conveying the sandwiched lamination board to the working room, and laminating the sandwiched lamination board, the prepregs, and the cores serially, thereby forming a multi-layer board.
    Type: Application
    Filed: October 30, 2003
    Publication date: May 6, 2004
    Inventor: Tse Ying Liu
  • Publication number: 20030106630
    Abstract: A pin lamination method that may eliminate pits and dents formed in a multi-layer printed wiring board, includes the steps of: (a) preparing steel plates and coppers in a clean working room, and preparing prepregs and cores in a working room; (b) laminating a first copper having a shiny surface facing upward, a steel plate, and a second copper having a shiny surface facing downward, thereby forming a sandwiched lamination board, with the steel plate sandwiched between the first and second coppers, wherein the shiny surface of each of the first and second coppers is directed toward the steel plate; and (c) conveying the sandwiched lamination board to the working room, and laminating the sandwiched lamination board, the prepregs, and the cores serially, thereby forming a multi-layer board.
    Type: Application
    Filed: December 10, 2001
    Publication date: June 12, 2003
    Inventor: Tse Ying Liu