Patents by Inventor Tslil GABRIELI

Tslil GABRIELI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and kits for fragmenting DNA
    Patent number: 11845928
    Abstract: A method of DNA fragmentation is provided. The method comprising incubating a semi-solid biological sample which comprises the DNA with an auxiliary domain-directed nuclease having a binding affinity and selectivity to pre-defined sites in the DNA so as to yield a DNA fragment-of-interest, to thereby fragment the DNA.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: December 19, 2023
    Assignee: Tsinghua University
    Inventors: Ting Zhu, Yuval Ebenstein, Chunbo Lou, Wenjun Jiang, Xuejin Zhao, Tslil Gabrieli
  • ANALYSIS OF METHYLATION STATUS AND COPY NUMBER
    Publication number: 20200248265
    Abstract: A method of diagnosing a disease associated with a DNA repeat sequence is disclosed. The method comprises: (a) determining the number of repeats of a DNA sequence in DNA molecules of a sample of the subject; and (b) determining the CpG methylation status of the DNA molecules, wherein the number of repeats of the DNA sequence and the CpG methylation status of the DNA molecules is indicative of the disease.
    Type: Application
    Filed: April 15, 2020
    Publication date: August 6, 2020
    Applicants: Ramot at Tel-Aviv University Ltd., Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
    Inventors: Yuval EBENSTEIN, Elmar WEINHOLD, Assaf GRUNWALD, Tslil GABRIELI
  • Analysis of methylation status and copy number
    Patent number: 10633706
    Abstract: A method of diagnosing a disease associated with a DNA repeat sequence is disclosed. The method comprises: (a) determining the number of repeats of a DNA sequence in DNA molecules of a sample of the subject; and (b) determining the CpG methylation status of the DNA molecules, wherein the number of repeats of the DNA sequence and the CpG methylation status of the DNA molecules is indicative of the disease.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: April 28, 2020
    Assignees: Ramot at Tel-Aviv University Ltd., Rheinisch-Westfälische Technische Hochschule (RWTH) Aaachen
    Inventors: Yuval Ebenstein, Elmar Weinhold, Assaf Grunwald, Tslil Gabrieli
  • ANALYSIS OF METHYLATION STATUS AND COPY NUMBER
    Publication number: 20190194755
    Abstract: A method of diagnosing a disease associated with a DNA repeat sequence is disclosed. The method comprises: (a) determining the number of repeats of a DNA sequence in DNA molecules of a sample of the subject; and (b) determining the CpG methylation status of the DNA molecules, wherein the number of repeats of the DNA sequence and the CpG methylation status of the DNA molecules is indicative of the disease.
    Type: Application
    Filed: August 10, 2017
    Publication date: June 27, 2019
    Applicants: Ramot at Tel-Aviv University Ltd., Rheinisch-Westfalische Technische Hochschule (RWTH) Aachen
    Inventors: Yuval EBENSTEIN, Elmar WEINHOLD, Assaf GRUNWALD, Tslil GABRIELI
  • METHODS AND KITS FOR FRAGMENTING DNA
    Publication number: 20180044659
    Abstract: A method of DNA fragmentation is provided. The method comprising incubating a semi-solid biological sample which comprises the DNA with an auxiliary domain-directed nuclease having a binding affinity and selectivity to pre-defined sites in the DNA so as to yield a DNA fragment-of-interest, to thereby fragment the DNA.
    Type: Application
    Filed: April 14, 2016
    Publication date: February 15, 2018
    Inventors: Ting ZHU, Yuval EBENSTEIN, Chunbo LOU, Wenjun JIANG, Xuejin ZHAO, Tslil GABRIELI