Patents by Inventor Tsu-An Hsu

Tsu-An Hsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to R-spondin 3
    Patent number: 11623951
    Abstract: Isolated antibodies that bind specifically to R-spondin 3 (RSPO3) are described. Also described herein are compositions containing the antibodies and methods of using the antibodies to treat cancer and detect RSPO3.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: April 11, 2023
    Assignee: National Health Research Institutes
    Inventors: Tsu-An Hsu, Hui-Chen Hung, Teng-Yuan Chang, Chuan Shih
  • Anti-Abeta antibodies and uses thereof
    Patent number: 11084873
    Abstract: An isolated antibody, comprising a light-chain CDR1 (L-CDR1) having the sequence of SEQ ID NO: 1, SEQ ID NO: 7, or SEQ ID NO: 14; a light-chain CDR2 (L-CDR2) having the sequence of SEQ ID NO: 2 or SEQ ID NO: 15; a light-chain CDR3 (L-CDR3) having the sequence of SEQ ID NO: 3, SEQ ID NO: 8, SEQ ID NO: 21, or SEQ ID NO: 24; a heavy-chain CDR1 (H-CDR1) having the sequence of SEQ ID NO: 4, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 16, or SEQ ID NO: 25; a heavy-chain CDR2 (H-CDR2) having the sequence of SEQ ID NO: 5, SEQ ID NO: 12, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 22, or SEQ ID NO: 26; and a heavy-chain CDR3 (H-CDR3) having the sequence of SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 13, SEQ ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 23, or SEQ ID NO: 27, wherein the antibody specifically binds to A?1-42 or an N-terminal modified form thereof.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: August 10, 2021
    Assignee: National Health Research Institutes
    Inventors: Feng-Shiun Shie, Tsu-An Hsu, Chuan Shih, Santai Shen
  • ANTI-RSPO3 ANTIBODIES
    Publication number: 20210163580
    Abstract: An isolated antibody, comprising: heavy chain complementary determining regions CDR1, CDR2, and CDR3 of a heavy chain variable region sequence selected from SEQ ID NOs: 2, 6, 10, and 14; and light chain complementary determining regions CDR1, CDR2, and CDR3 of a light chain variable region sequence selected from SEQ ID NOs: 4, 8, 12, and 16; wherein the antibody binds specifically to a RSPO3 protein.
    Type: Application
    Filed: December 6, 2018
    Publication date: June 3, 2021
    Applicant: National Health Research Institutes
    Inventors: Tsu-An Hsu, Hui-Chen Hung, Teng-Yuan Chang, Chuan Shih
  • ANTI-Abeta ANTIBODIES AND USES THEREOF
    Publication number: 20190367593
    Abstract: An isolated antibody, comprising a light-chain CDR1 (L-CDR1) having the sequence of SEQ ID NO: 1, SEQ ID NO: 7, or SEQ ID NO: 14; a light-chain CDR2 (L-CDR2) having the sequence of SEQ ID NO: 2 or SEQ ID NO: 15; a light-chain CDR3 (L-CDR3) having the sequence of SEQ ID NO: 3, SEQ ID NO: 8, SEQ ID NO: 21, or SEQ ID NO: 24; a heavy-chain CDR1 (H-CDR1) having the sequence of SEQ ID NO: 4, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 16, or SEQ ID NO: 25; a heavy-chain CDR2 (H-CDR2) having the sequence of SEQ ID NO: 5, SEQ ID NO: 12, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 22, or SEQ ID NO: 26; and a heavy-chain CDR3 (H-CDR3) having the sequence of SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 13, SEQ ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 23, or SEQ ID NO: 27, wherein the antibody specifically binds to A?1-42 or an N-terminal modified form thereof.
    Type: Application
    Filed: May 30, 2019
    Publication date: December 5, 2019
    Inventors: Feng-Shiun Shie, Tsu-An Hsu, Chuan Shih, Santai Shen
  • Aminothiazole compounds
    Patent number: 10047078
    Abstract: Aminothiazole compounds of Formula (I) shown herein and pharmaceutical compositions containing one of such compounds.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: August 14, 2018
    Assignee: National Health Research Institutes
    Inventors: Weir-Torn Jiaang, Tsu Hsu
  • AMINOTHIAZOLE COMPOUNDS
    Publication number: 20170226100
    Abstract: Aminothiazole compounds of Formula (I) shown herein and pharmaceutical compositions containing one of such compounds.
    Type: Application
    Filed: January 30, 2017
    Publication date: August 10, 2017
    Inventors: Weir-Torn Jiaang, Tsu Hsu
  • Pyrazole compounds and thiazole compounds as protein kinases inhibitors
    Patent number: 9255072
    Abstract: A compound of formula (I): wherein A, B, D, X, Y, R1, R2, R3, m, p, and q are defined herein. Also disclosed is a method for inhibiting FMS-like tyrosine kinase 3, aurora kinase, or vascular endothelial growth factor receptor.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: February 9, 2016
    Assignee: National Health Rsearch Institutes
    Inventors: Weir-Torn Jiaang, Tsu-An Hsu, Wen-Hsing Lin, Yu-Sheng Chao
  • Quinoline compounds and their use for treating viral infection
    Patent number: 8710079
    Abstract: Quinoline compounds of formula (I): in which A, B, D, E, F, G, R1, R2, R3, X, Y, n, p, and q are defined herein. Also disclosed is a method for treating a viral infection with a compound of formula (I).
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: April 29, 2014
    Assignee: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Tsu-An Hsu, Jiann-Yih Yeh, Yu-Sheng Chao
  • Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors
    Patent number: 8507502
    Abstract: Fused bicyclic or tricyclic compounds of formula (I): wherein A, B, C, X, Y, m, and n are defined herein. Also disclosed are a method for inhibiting EGFR kinase activity and a method for treating cancer with these compounds.
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: August 13, 2013
    Assignee: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Selvaraj Mohane Coumar, Tsu-An Hsu, Wen-Hsing Lin, Yi-Rong Chen, Yu-Sheng Chao
  • PYRAZOLE COMPOUNDS AND THIAZOLE COMPOUNDS AS PROTEIN KINASES INHIBITORS
    Publication number: 20120225880
    Abstract: A compound of formula (I): wherein A, B, D, X, Y, R1, R2, R3, m, p, and q are defined herein. Also disclosed is a method for inhibiting FMS-like tyrosine kinase 3, aurora kinase, or vascular endothelial growth factor receptor.
    Type: Application
    Filed: March 1, 2012
    Publication date: September 6, 2012
    Applicant: National Health Research Institutes
    Inventors: Weir-Torn Jiaang, Tsu-An Hsu, Wen-Hsing Lin, Yu-Sheng Chao
  • Fused bicyclic pyrimidine compounds as aurora kinase inhibitors
    Patent number: 8138194
    Abstract: Fused bicyclic pyrimidine compounds of formula (I): wherein R1, R3, R4, X1, X2, Y, Z, A, B, C, D, n, and the two bonds are defined herein. Also disclosed are a method for inhibiting Aurora kinase activity and a method for treating cancer with these compounds.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: March 20, 2012
    Assignee: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Selvaraj Mohane Coumar, Tsu-An Hsu, Su-Ying Wu, Yu-Sheng Chao
  • COUMARIN COMPOUNDS AND THEIR USE FOR TREATING VIRAL INFECTION
    Publication number: 20120046238
    Abstract: A method for treating an infection with a virus. The method includes administering to a subject in need thereof an effective amount of one or more coumarin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, and X are defined herein. Also disclosed is a pharmaceutical composition including a coumarin compound.
    Type: Application
    Filed: November 10, 2011
    Publication date: February 23, 2012
    Applicant: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Tsu-An Hsu, Jiann-Yih Yeh, Jim-Tong Horng, Shin-Ru Shih, Sui-yuan Chang, Yu-Sheng Chao
  • Extracts from
    Patent number: 8048426
    Abstract: An invention relates to an extract of Chlorella sorokiniana, which contains myristic acid, palmitic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, and stearic acid. Also related is use of this extract to treat diabetes, obesity, and dyslipidaemia.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: November 1, 2011
    Assignee: International Chlorella Co., Ltd.
    Inventors: Hsing-Pang Hsieh, Tsu-An Hsu, Yu-Sheng Chao, Yu-Cheng Chou, Shun Te Wang
  • QUINOLINE COMPOUNDS AND THEIR USE FOR TREATING VIRAL INFECTION
    Publication number: 20110263620
    Abstract: Quinoline compounds of formula (I): in which A, B, D, E, F, G, R1, R2, R3, X, Y, n, p, and q are defined herein. Also disclosed is a method for treating a viral infection with a compound of formula (I).
    Type: Application
    Filed: April 21, 2011
    Publication date: October 27, 2011
    Applicant: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: Hsing-Pang HSIEH, Tsu-An HSU, Jiann-Yih YEH, Yu-Sheng CHAO
  • Pyrrolidine derivatives
    Patent number: 8022096
    Abstract: Pyrrolidine compounds described herein and methods for using them to inhibit dipeptidyl peptidase IV and treat Type II diabetes.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: September 20, 2011
    Assignee: National Health Research Institutes
    Inventors: Weir-Torn Jiaang, Yu-Sheng Chao, Ting-Yueh Tsai, Tsu Hsu
  • Hepatitis C virus inhibitors
    Patent number: 7985763
    Abstract: A compound of the following formula: in which R1, R2, R3, U, V, T, W, X, Y, Z, m, n, p, x, y, and z are as defined herein. Also disclosed are (1) a pharmaceutical composition containing such a compound, and (2) a method for treating Hepatitis C virus infection using such a compound.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: July 26, 2011
    Assignee: National Health Research Institutes
    Inventors: Li-Wen Wang, Tsu-An Hsu, Yen-Chun Lee, Iou-Jiun Kang, Chung-Chi Lee, Yu-Sheng Chao, Jyh-Haur Chern
  • Imidazolidinone and imidazolidinethione derivatives
    Patent number: 7939523
    Abstract: Imidazolidinone and imidazolinethione compounds of formula (I): wherein R1, R2, R3, A1, A2, X, Y, Z, m, n, p, x, and y are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: May 10, 2011
    Assignee: National Health Research Institutes
    Inventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yen-Shian Wu, Sheng-Ju Hsu, Yueh Andrew Yueh, Yu-Sheng Chao
  • Thiourea derivatives
    Patent number: 7897764
    Abstract: Thiourea compounds of the following formula: wherein n, R1, R2, R3, A1, A2, X, Y, and Z are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: March 1, 2011
    Assignee: National Health Research Institutes
    Inventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yu-Sheng Chao
  • Fused Bicyclic and Tricyclic Pyrimidine Compounds as Tyrosine Kinase Inhibitors
    Publication number: 20100120805
    Abstract: Fused bicyclic or tricyclic compounds of formula (I): wherein A, B, C, X, Y, m, and n are defined herein. Also disclosed are a method for inhibiting EGFR kinase activity and a method for treating cancer with these compounds.
    Type: Application
    Filed: November 9, 2009
    Publication date: May 13, 2010
    Applicant: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Selvaraj Mohane Coumar, Tsu-An Hsu, Wen-Hsing Lin, Yi-Rong Chen, Yu-Sheng Chao
  • COUMARIN COMPOUNDS AND THEIR USE FOR TREATING VIRAL INFECTION
    Publication number: 20090312406
    Abstract: A method for treating an infection with a virus. The method includes administering to a subject in need thereof an effective amount of one or more coumarin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, and X are defined herein. Also disclosed is a pharmaceutical composition including a coumarin compound.
    Type: Application
    Filed: June 10, 2009
    Publication date: December 17, 2009
    Inventors: Hsing-Pang Hsieh, Tsu-An Hsu, Jiann-Yih Yeh, Jim-Tong Horng, Shin-Ru Shih, Sui-yuan Chang, Yu-Sheng Chao