Abstract: The present invention integrates an optical switch, a microlens array and a triple-unit light-directed combinatorial synthesis. By applying optical switching technology and waveguides, the present invention can actively control and carry out light-directed solid-state combinatorial synthesis without implementation of photomasks. The system and the related methodologies of this invention further incorporate individually independent detection for each spot of the microarray system without background interference. Microlens arrays coupled with the optical waveguide switch can be implemented in the CCD-LED detection system or laser scanning system for microarray detection in the present invention.