Patents by Inventor Tsu-Ju Fu
Tsu-Ju Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11639937Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: GrantFiled: April 21, 2022Date of Patent: May 2, 2023Assignee: SIRIGEN II LIMITEDInventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Publication number: 20220260578Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: ApplicationFiled: April 21, 2022Publication date: August 18, 2022Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Publication number: 20220260579Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: ApplicationFiled: April 21, 2022Publication date: August 18, 2022Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Publication number: 20220082568Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: ApplicationFiled: November 19, 2021Publication date: March 17, 2022Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Patent number: 11209438Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: GrantFiled: July 31, 2019Date of Patent: December 28, 2021Assignee: Becton, Dickinson and CompanyInventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Patent number: 10859578Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: GrantFiled: October 8, 2018Date of Patent: December 8, 2020Assignee: SKIGEN, INC.Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Patent number: 10641777Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: GrantFiled: October 31, 2017Date of Patent: May 5, 2020Assignee: SIRIGEN, INC.Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Publication number: 20190376977Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: ApplicationFiled: July 31, 2019Publication date: December 12, 2019Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Publication number: 20190033317Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: ApplicationFiled: October 8, 2018Publication date: January 31, 2019Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Patent number: 10126302Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: GrantFiled: May 23, 2016Date of Patent: November 13, 2018Assignee: SIRIGEN II LIMITEDInventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Patent number: 10112969Abstract: Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex comprising proofreading activity. The nucleotide analogs may become incorporated into a replicating strand and induce the proofreading activity of the polymerizing enzyme, thereby prolonging the duration of a signal associated with nucleotide incorporation, resulting in more observable sequencing events and increasing the accuracy of nucleic acid sequencing.Type: GrantFiled: May 8, 2017Date of Patent: October 30, 2018Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Chung-Fan Chiou, Chao-Chi Pan, Jenn-Yeh Fann, Shang-Chia Chang, Tsu-Ju Fu
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Patent number: 10107818Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: GrantFiled: November 29, 2016Date of Patent: October 23, 2018Assignee: Sirigen II LimitedInventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Patent number: 10087207Abstract: This invention is to describe nucleotide analogs used in a method for the determination of a nucleic acid sequence. The method involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.Type: GrantFiled: November 25, 2016Date of Patent: October 2, 2018Assignee: Personal Genomics, Inc.Inventors: Tsu-Ju Fu, Shang-Chia Chang, Jenn-Yeh Fann
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Publication number: 20180111959Abstract: Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex comprising proofreading activity. The nucleotide analogs may become incorporated into a replicating strand and induce the proofreading activity of the polymerizing enzyme, thereby prolonging the duration of a signal associated with nucleotide incorporation, resulting in more observable sequencing events and increasing the accuracy of nucleic acid sequencing.Type: ApplicationFiled: May 8, 2017Publication date: April 26, 2018Applicant: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Chao-Chi Pan, Jenn-Yeh Fann, Shang-Chia Chang, Tsu-Ju Fu
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Publication number: 20180059117Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: ApplicationFiled: October 31, 2017Publication date: March 1, 2018Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Patent number: 9670243Abstract: Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex comprising proofreading activity. The nucleotide analogs may become incorporated into a replicating strand and induce the proofreading activity of the polymerizing enzyme, thereby prolonging the duration of a signal associated with nucleotide incorporation, resulting in more observable sequencing events and increasing the accuracy of nucleic acid sequencing.Type: GrantFiled: May 27, 2011Date of Patent: June 6, 2017Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Chung-Fan Chiou, Chao-Chi Pan, Jenn-Yeh Fann, Shang-Chia Chang, Tsu-Ju Fu
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Publication number: 20170115298Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: ApplicationFiled: November 29, 2016Publication date: April 27, 2017Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
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Publication number: 20170073752Abstract: This invention is to describe nucleotide analogs used in a method for the determination of a nucleic acid sequence. The method involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.Type: ApplicationFiled: November 25, 2016Publication date: March 16, 2017Applicant: Personal Genomics, Inc.Inventors: Tsu-Ju Fu, Shang-Chia Chang, Jenn-Yeh Fann
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Patent number: 9540688Abstract: This invention is to describe a method for the determination of a nucleic acid sequence, in which it involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.Type: GrantFiled: December 11, 2014Date of Patent: January 10, 2017Assignee: Personal Genomics, Inc.Inventors: Tsu-Ju Fu, Shang-Chia Chang, Jenn-Yeh Fann
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Publication number: 20160266132Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.Type: ApplicationFiled: May 23, 2016Publication date: September 15, 2016Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi