Abstract: In systems and methods of detecting malicious software, a software agent comprising at least one scan module is assembled by a source system and is transferred by the source system to a target system. In response to a connection request from the software agent a connection is established to the software agent and a file is received from the target system. At the source system, a static analysis is performed on the transferred file to generate a static threat score, and a dynamic analysis is performed to generate a dynamic threat score. Based on the static threat score and the dynamic threat score an aggregate threat score is generated for the transferred file.