Patents by Inventor Tsugio Tomiyoshi

Tsugio Tomiyoshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compound having effect of promoting neuron differentiation
    Patent number: 6384063
    Abstract: A novel cystacycline derivative which has an excellent effect of promoting the differentiation of neurons and is useful as a remedy for central nervous system disorders, a remedy for peripheral nerve disorders, etc.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: May 7, 2002
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Seiichi Saito, Masashi Nagai, Tomio Morino, Tsugio Tomiyoshi, Takaaki Nishikiori, Atsushi Kuwahara, Takamichi Sato, Takashi Harada
  • Spergualin-related compound and use thereof
    Patent number: 5137917
    Abstract: Novel spergualin-related compounds represented by the general formula (I): ##STR1## wherein X represents --(CH.sub.2).sub.1-5 -- or a phenylene group which may be substituted; m represents 0, 1 or 2; n represents 1 or 2; and R.sub.1 represents --(CH.sub.2).sub.1-3 --COOH, and pharmacologically acceptable salts thereof, possess an immunopotentiating activity, and are expected to be useful as immunopotentiators applicable to warm blooded animals.
    Type: Grant
    Filed: July 17, 1991
    Date of Patent: August 11, 1992
    Assignees: Nippon Kayaku Kabushiki Kaisha, Takara Shuzo Co., Ltd.
    Inventors: Tsugio Tomiyoshi, Takako Mae, Tetsushi Saino, Yoshihisa Umeda
  • Novel spergualin-related compounds and compositions
    Patent number: 5061787
    Abstract: The present invention relates to novel spergualin-related compounds represented by the general formula [I]: ##STR1## wherein X is --(CH.sub.2).sub.1.about.5 or ##STR2## Y is a hydrogen atom or a residue obtained by removing a hydroxyl group from the carboxyl group of an amino acid or a peptide; m is 0, 1 or 2 and n is 1 or 2, with the proviso that Y is not a hydrogen atom when n is 2 and m is 0.This compounds are stable and exhibit a high immunosuppressive activity.
    Type: Grant
    Filed: June 8, 1989
    Date of Patent: October 29, 1991
    Assignees: Nippon Kayaku Kabushiki Kaisha, Takara Shuzo Kabushiki Kaisha
    Inventors: Tetsushi Saino, Tsugio Tomiyoshi, Kyuichi Nemoto, Yoshihisa Umeda
  • Immunopotentiator and spergualin-related compound therefor
    Patent number: 4990536
    Abstract: The present invention provides a use for the preparation of an immunopotentiator of a spergualin-related compound represented by the following general formula [I] or a pharmacologically acceptable salt thereof: ##STR1## wherein X represents ##STR2## or --(CH.sub.2).sub.n --, Y represents a hydrogen atom or a hydroxyl or hydroxymethyl group,n is an integer of 3 or 5, andR represents --(CH.sub.2).sub.4 --R.sub.1 (wherein R.sub.1 is --NH.sub.2 or --OH), --(CH.sub.2).sub.3 --R.sub.2 (wherein R.sub.2 is --COOH or --CHO), --(CH.sub.2).sub.4 --NH--(CH.sub.2).sub.3 --OH or --(CH.sub.2).sub.4 --NH--(CH.sub.2).sub.2 --R.sub.2 (wherein R.sub.2 is as defined above).
    Type: Grant
    Filed: March 16, 1990
    Date of Patent: February 5, 1991
    Assignees: Nippon Kayaku Kabushiki Kaisha, Takara Shuzo Co., Ltd.
    Inventors: Takeji Sakasai, Tsugio Tomiyoshi, Keiko Watanabe, Kyuichi Nemoto, Tetushi Saino, Yoshihisa Umeda