Patents by Inventor Tsuhen Chang

Tsuhen Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Redox-activated pro-chelators
    Patent number: 11504346
    Abstract: Compositions of pro-chelator compounds are described herein. The pro-chelators may be activated in reducing conditions, such as in the intracellular space, so as to sequester metals such as iron. The pro-chelators may be used to target malignant cells or in the treatment in a condition associated with metal ion disregulation.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: November 22, 2022
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Elisa Tomat, Tsuhen Chang, Eman A. Akam
  • REDOX-ACTIVATED PRO-CHELATORS
    Publication number: 20190091183
    Abstract: Compositions of pro-chelator compounds are described herein. The pro-chelators may be activated in reducing conditions, such as in the intracellular space, so as to sequester metals such as iron. The pro-chelators may be used to target malignant cells or in the treatment in a condition associated with metal ion disregulation.
    Type: Application
    Filed: November 26, 2018
    Publication date: March 28, 2019
    Inventors: Elisa Tomat, Tsuhen Chang, Eman A. Akam
  • REDOX-DIRECTED CHELATORS TARGETING INTRACELLULAR METAL IONS
    Publication number: 20170112788
    Abstract: The present invention provides redox-activated chelators and methods for using the same to treat cancer. In one particular embodiment, the redox-activated chelator is of the formula: wherein each of m and n is an integer from 0 to 4; each of Ar1 and Ar2 is independently aryl or heteroaryl; each of R1, R2, R5 and R6 is independently hydrogen, alkyl, aryl, electron withdrawing group or an anion stabilizing group; each of R3 and R4 is independently alkyl, halide, or other electron withdrawing group or an anion stabilizing group.
    Type: Application
    Filed: November 7, 2016
    Publication date: April 27, 2017
    Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Elisa Tomat, Tsuhen Chang
  • Redox-directed chelators targeting intracellular metal ions
    Patent number: 9486423
    Abstract: The present invention provides redox-activated chelators and methods for using the same to treat cancer. In one particular embodiment, the redox-activated chelator is of the formula: wherein each of m and n is an integer from 0 to 4; each of Ar1 and Ar2 is independently aryl or heteroaryl; each of R1, R2, R5 and R6 is independently hydrogen, alkyl, aryl, electron withdrawing group or an anion stabilizing group; each of R3 and R4 is independently alkyl, halide, or other electron withdrawing group or an anion stabilizing group.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: November 8, 2016
    Assignee: The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Elisa Tomat, Tsuhen Chang
  • REDOX-DIRECTED CHELATORS TARGETING INTRACELLULAR METAL IONS
    Publication number: 20150126610
    Abstract: The present invention provides redox-activated chelators and methods for using the same to treat cancer. In one particular embodiment, the redox-activated chelator is of the formula: wherein each of m and n is an integer from 0 to 4; each of Ar1 and Ar2 is independently aryl or heteroaryl; each of R1, R2, R5 and R6 is independently hydrogen, alkyl, aryl, electron withdrawing group or an anion stabilizing group; each of R3 and R4 is independently alkyl, halide, or other electron withdrawing group or an anion stabilizing group.
    Type: Application
    Filed: November 3, 2014
    Publication date: May 7, 2015
    Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Elisa Tomat, Tsuhen Chang