Abstract: The invention is directed to a method for manufacturing an interconnect structure suitable for a substrate having a semiconductor device formed thereon, wherein the semiconductor device possesses a metal silicide layer predetermined as an electrically connecting region. The method comprises steps of forming a conformal adhesion layer over the substrate, forming a dielectric layer on the conformal adhesion layer and then performing a chemical mechanical polishing process to planarize the dielectric layer. Further, an opening penetrating through the dielectric layer and the conformal adhesion layer is formed, wherein the opening exposes a portion of the metal silicide layer. A conductive plug is formed in the opening.