Patents by Inventor Tsukasa Ishihara
Tsukasa Ishihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100247762Abstract: In a coating zone, a cylindrical tube is soaked in and taken out from a solution, such that a coating film is formed on a curved surface of the tube. In a wet gas zone, while a first gas feeding nozzle having a gas outlet moves in a state where the gas outlet faces an outer peripheral surface of the tube, wet gas is blown toward the coating film through the gas outlet. Water drops are generated on the coating film and grown up. In a dry gas zone, as in the case of the first gas feeding nozzle, while a second gas feeding nozzle having a gas outlet moves, dry gas is blown toward the coating film through the gas outlet. Solvent and water drops are evaporated from the coating film. Pores form from the water drops as a template for the porous material on the coating film.Type: ApplicationFiled: March 30, 2010Publication date: September 30, 2010Applicant: FUJIFILM CORPORATIONInventors: Koju ITO, Tsukasa ISHIHARA, Hidekazu YAMAZAKI
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Publication number: 20100227866Abstract: [Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). [Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.Type: ApplicationFiled: May 26, 2008Publication date: September 9, 2010Applicant: ASTELLAS PHARMA INC.Inventors: Hiroyuki Hisamichi, Itsuro Shimada, Tsukasa Ishihara, Tomofumi Takuwa, Takafumi Shimizu, Noriko Ishikawa, Kyoichi Maeno, Norio Seki
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Patent number: 7786106Abstract: There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4?-bromo-2?-[(5-chloro-2-pyridyl) carbamoyl]-6?-?-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2?-(2-acetamido-2-deoxy-?-D-glucopyranosyloxy)-4?-bromo-6?-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.Type: GrantFiled: January 20, 2009Date of Patent: August 31, 2010Assignee: Astellas Pharma Inc.Inventors: Tsukasa Ishihara, Fukushi Hirayama, Keizo Sugasawa, Yuji Koga, Takeshi Kadokura, Takeshi Shigenaga
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Publication number: 20100080917Abstract: A solution containing a polymer and a solvent is discharged onto a surface of a polymer film to form a coating film. When a thickness of the coating film is a critical thickness or less, dewetting of the solution occurs on the surface, and the coating film becomes a dewetting material having dewetting pores. Wet air is blown to a surface of the dewetting material. The solvent is evaporated from the dewetting material. Water vapor is condensed from ambient air on the surface of the dewetting material to generate water drops. Dry air is blown to the surface of the dewetting material. The solvent and the water drops are evaporated from the dewetting material. Thereby, it is possible to produce a porous material whose surface includes first pores as the dewetting pores formed by the dewetting of the solution and the second pores formed by the water drops as a template for the porous material.Type: ApplicationFiled: September 29, 2009Publication date: April 1, 2010Applicant: FUJIFILM CorporationInventors: Hidekazu Yamazaki, Tsukasa Ishihara, Koju Ito
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Publication number: 20100040789Abstract: A coating liquid containing a polymer and a hydrophobic solvent is applied to a support to form a coating layer. In a humidifying process with high humidity, the coating layer is set under an atmosphere having a first dew point higher than a surface temperature of the coating layer. Then, in a humidifying process with low humidity, the coating layer is set under an atmosphere having a second dew point higher than the surface temperature of the coating layer and lower than the first dew point. Thereby, water vapor is condensed from ambient air on the coating layer to generate minuscule water drops. Thereafter, the coating layer is dried to form a porous film having plural pores made by the minuscule water drops as a template. Since the humidifying process with high humidity is performed for a short period of time and then the humidifying process with low humidity is performed, the minuscule water drops are prevented from growing up, to obtain a porous film having minute pores.Type: ApplicationFiled: September 18, 2009Publication date: February 18, 2010Applicant: FUJIFILM CORPORATIONInventors: Koju Ito, Tsukasa Ishihara, Hidekazu Yamazaki
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Publication number: 20090246865Abstract: A porous film is used as a cell culture substrate that is a scaffold for a spheroid. The porous film has a plurality of pores whose diameters gradually increase in a direction A. The diameters of the pores gradually increase from a first area P1 to a third area P3 in this order. The first to the third areas P1 to P3 are located on the porous film along the direction A. The diameters and depths of the pores increase in proportion to the distance in the direction A.Type: ApplicationFiled: March 26, 2009Publication date: October 1, 2009Applicant: FUJIFILM CorporationInventors: Hidekazu YAMAZAKI, Tsukasa Ishihara
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Publication number: 20090137498Abstract: There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4?-bromo-2?-[(5-chloro-2-pyridyl)carbamoyl]-6?-?-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2?-(2-acetamido-2-deoxy-?-D-glucopyranosyloxy)-4?-bromo-6?-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.Type: ApplicationFiled: January 20, 2009Publication date: May 28, 2009Applicant: ASTELLAS PHARMA INC.Inventors: Tsukasa Ishihara, Fukushi Hirayama, Keizo Sugasawa, Yuji Koga, Takeshi Kadokura, Takeshi Shigenaga
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Patent number: 7504417Abstract: There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4?-bromo-2?-[(5-chloro-2-pyridyl)carbamoyl]-6?-?-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2?-(2-acetamido-2-deoxy-?-D-glucopyranosyloxy)-4?-bromo-6?-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.Type: GrantFiled: November 21, 2001Date of Patent: March 17, 2009Assignee: Astellas Pharma Inc.Inventors: Tsukasa Ishihara, Fukushi Hirayama, Keizo Sugasawa, Yuji Koga, Takeshi Kadokura, Takeshi Shigenaga
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Patent number: 7307074Abstract: To provide a compound which has an anticoagulation action based upon inhibition of activated blood coagulation factor X and is useful as an anticoagulant or an agent for prevention and treatment of diseases caused by thrombus or embolus. A diazepan derivative such as 4-[(3-carbamimidoylphenylamino)methyl]-3-[4-(4-methyl-1,4-diazepan-1-yl)benzoylamino]benzoic acid and 3-hydroxy-4?-methoxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzanilide or a salt thereof is an effective ingredient.Type: GrantFiled: September 8, 2003Date of Patent: December 11, 2007Assignee: Astellas Pharma Inc.Inventors: Fukushi Hirayama, Hiroyuki Koshio, Tsukasa Ishihara, Norio Seki, Shunichiro Hachiya, Keizo Sugasawa, Ryota Shiraki, Yuji Koga, Yuzo Matsumoto, Takeshi Shigenaga, Souichirou Kawazoe
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Publication number: 20040077555Abstract: There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl)carbamoyl]-6′-&bgr;-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-&bgr;-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.Type: ApplicationFiled: September 10, 2003Publication date: April 22, 2004Inventors: Tsukasa Ishihara, Fukushi Hirayama, Keizo Sugasawa, Yuji Koga, Takeshi Kadokura, Takeshi Shigenaga
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Publication number: 20040068109Abstract: To provide a compound which has an anticoagulation action based upon inhibition of activated blood coagulation factor X and is useful as an anticoagulant or an agent for prevention and treatment of diseases caused by thrombus or embolus. A diazepan derivative such as 4-[(3-carbamimidoylphenylamino)methyl]-3-[4-(4-methyl-1,4-diazepan-1-yl)benzoylamino]benzoic acid and 3-hydroxy-4′-methoxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzanilide or a salt thereof is an effective ingredient.Type: ApplicationFiled: September 8, 2003Publication date: April 8, 2004Applicant: YAMANOUCHI PHARMACEUTICAL CO. LTD.Inventors: Fukushi Hirayama, Hiroyuki Koshio, Tsukasa Ishihara, Norio Seki, Shunichiro Hachiya, Keizo Sugasawa, Ryota Shiraki, Yuji Koga, Yuzo Matsumoto, Takeshi Shigenaga, Souichirou Kawazoe
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Patent number: 6642224Abstract: To provide a compound which has an anticoagulation action based upon inhibition of activated blood coagulation factor X and is useful as an anticoagulant or an agent for prevention and treatment of diseases caused by thrombus or embolus. A diazepan derivative such as 4-[(3-carbamimidoylphenylamino)methyl]-3-[4-(4-METHYL-1,4-diazepan-1-yl)benzoylamino]benzoic acid and 3-hydroxy-4′-methoxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzanilide or a salt thereof is an effective ingredient.Type: GrantFiled: October 2, 2002Date of Patent: November 4, 2003Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Fukushi Hirayama, Hiroyuki Koshio, Tsukasa Ishihara, Norio Seki, Shunichiro Hachiya, Keizo Sugasawa, Ryota Shiraki, Yuji Koga, Yuzo Matsumoto, Takeshi Shigenaga, Souichirou Kawazoe
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Publication number: 20030195193Abstract: To provide a compound which has an anticoagulation action based upon inhibition of activated blood coagulation factor X and is useful as an anticoagulant or an agent for prevention and treatment of diseases caused by thrombus or embolus. A diazepan derivative such as 4-[(3-carbamimidoylphenylamino)methyl]-3-[4-(4-methyl-1,4-diazepan-1-yl)benzoylamino]benzoic acid and 3-hydroxy-4′methoxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzanilide or a salt thereof is an effective ingredient.Type: ApplicationFiled: October 2, 2002Publication date: October 16, 2003Inventors: Fukushi Hirayama, Hiroyuki Koshio, Tsukasa Ishihara, Norio Seki, Shunichiro Haehiya, Keizo Sugasawa, Ryota Shiraki, Yuji Koga, Yuzo Matsumoto, Takeshi shigenaga, Souichirou Kawazoe
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Patent number: 6333320Abstract: Hexahydro-1,4-diazepine derivatives represented by general formula (I); pharmaceutically acceptable salts thereof; and drugs containing the same as the active ingredient, such as activated blood coagulation factor X inhibitor, wherein A: phenylene, pyridylene, or the like; B: a 5- or 6-membered aryl or heteroaryl ring; X: —CO—, —CONH—, —CSNH—, —SO2—, —SO2NH—, or the like; Y: a bond or alkylene; R1: hydrogen, alkyl, —Y—(hetero) aryl, or the like; R2: hydrogen, alkoxy, —COOH, or the like; R3: amidino or a group capable of being converted into amidino; and R4, R5: each independently hydrogen or lower alkyl.Type: GrantFiled: January 19, 2000Date of Patent: December 25, 2001Assignee: Yamanouchi Pharmaceutical Co.Inventors: Hiroyuki Koshio, Fukushi Hirayama, Tsukasa Ishihara, Masashi Funatsu, Tomihisa Kawasaki, Yuzo Matsumoto
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Patent number: 5830902Abstract: A quinuclidine derivative represented by the following general formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, which has strong squalene synthase inhibiting activity and is useful as a cholesterol lowering agent without causing side effects. ##STR1## (Symbols in the formula represent the following meanings; R.sub.1 : a hydrogen atom, a halogen atom or a lower alkyl group,R.sub.2 : a hydrogen atom, a hydroxyl group or a lower alkoxy group,. . : a single bond or a double bond, with the proviso thatR.sub.2 does not exist when . . . is a double bond,X and Y: the same or different from each other and each represents a bond, an oxygen atom (--O--), a carbonyl group (--CO--), a group represented by the formula --S(O).sub.p -- or a group represented by the formula --NR.sub.3 --,p: 0, 1 or 2,R.sub.3 : a hydrogen atom or a lower alkyl group which may have a substituent,A: a saturated or unsaturated lower alkylene group, a group of the formula --(CH.sub.2).sub.m Z(CH.sub.Type: GrantFiled: August 21, 1997Date of Patent: November 3, 1998Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masahiko Isaka, Tsukasa Ishihara, Koyo Matsuda, Hirotoshi Kakuta, Hiroshi Moritani
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Patent number: 5807880Abstract: An azole derivative represented by the following general formula (I) ##STR1## (symbols in the formula have the following meanings; R.sup.1 and R.sup.2 : the same or different from each other and each represents a hydrogen atom, a lower alkyl group or a phenyl group which may be substituted with a halogen atom,A, B and D: the same or different from one another and each represents a group represented by the formula ##STR2## or a nitrogen atom,X and Y: the same or different from each other and each represents a single bond, a methylene group, an oxygen atom,a group represented by a formula S(O).sub.n, or a group represented by the formula ##STR3## R.sup.3 and R.sup.4 : the same or different from each other and each represents a hydrogen atom or a lower alkyl group, andn: 0, 1 or 2),a salt thereof, a hydrate thereof or a solvate thereof.Type: GrantFiled: March 26, 1996Date of Patent: September 15, 1998Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Minoru Okada, Toru Yoden, Eiji Kawaminami, Yoshiaki Shimada, Tsukasa Ishihara, Masafumi Kudou