Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: In a motor-driven power steering apparatus having a preload means which energizes a bearing of a worm gear in a predetermined preload direction, the preload means has a guide case as well as having a bearing case, and the guide case accommodating the bearing case in which the bearing and a spring are accommodated is attached to an attaching portion which is provided in a gear housing.

Abstract: As a result of producing anti-DDR1 antibodies and conducting extensive studies on the antitumor activity thereof, antibodies that bind to the stalk domain in the amino acid sequence of human DDR1 were found to have a potent activity even when used alone compared to antibodies that bind to other domains. It was also found that the antibodies have one or more activities selected from the group consisting of: (i) an activity to suppress cell proliferation, (ii) an activity to inhibit cell migration, (iii) an activity to inhibit phosphorylation of DDR1 in cells, (iv) an activity to be taken up into cells, (v) an activity to decrease the expression level of DDR1 in cells, and (vi) an activity to decrease the expression level of TGF-? in cells.

Abstract: Disclosed is a relative angle detection device for detecting a relative angle between a first rotary shaft and a second rotary shaft, the relative angle detection device being provided with a first magnetic field sensing unit which outputs a value according to a magnetic field of a magnet, a second magnetic field sensing unit which outputs a value according to the magnetic field of the magnet and outputs a value different from the output value of the first magnetic field sensing unit even if being placed in the same magnetic field as that of the first magnetic field sensing unit, a correction unit which corrects one output value out of the output value of the first magnetic field sensing unit and the output value of the second magnetic field sensing unit in accordance with an amplitude ratio between magnetic field components orthogonal to each other in the magnetic field of the magnet, and a computing unit which computes the relative angle between the first rotary shaft and the second rotary shaft on the basi

Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: In a motor-driven power steering apparatus having a preload means which energizes a bearing of a worm gear in a predetermined preload direction, the preload means has a guide case as well as having a bearing case, and the guide case accommodating the bearing case in which the bearing and a spring are accommodated is attached to an attaching portion which is provided in a gear housing.

Abstract: Disclosed is a relative angle detection device for detecting a relative angle between a first rotary shaft and a second rotary shaft, the relative angle detection device being provided with a first magnetic field sensing unit which outputs a value according to a magnetic field of a magnet, a second magnetic field sensing unit which outputs a value according to the magnetic field of the magnet and outputs a value different from the output value of the first magnetic field sensing unit even if being placed in the same magnetic field as that of the first magnetic field sensing unit, a correction unit which corrects one output value out of the output value of the first magnetic field sensing unit and the output value of the second magnetic field sensing unit in accordance with an amplitude ratio between magnetic field components orthogonal to each other in the magnetic field of the magnet, and a computing unit which computes the relative angle between the first rotary shaft and the second rotary shaft on the basi

Abstract: For the first time, the present invention provides antibodies that enhance the generation of activated blood coagulation factor VIII. The antibodies enhance the cleavage of blood coagulation factor VIII at the Arg of position 372 and suppress the cleavage at the Arg of position 336 by recognizing and binding to the A2 domain of blood coagulation Factor VIII. Such antibodies are expected to be useful in preventing or treating diseases that develop or progress due to decrease or loss of the blood coagulation factor VIII activity, for example, hemophilia A, acquired hemophilia, and von Willebrand's disease.

Abstract: The present inventors have succeeded in producing anti-AXL antibodies with specific functions. The present inventors also discovered that the antibodies have an angiogenesis-suppressive effect and an antitumor effect, and thereby completed the present invention. The anti-AXL antibodies of the present invention are useful as angiogenesis inhibitors and agents for inducing or inhibiting phosphorylation activity.

Abstract: For the first time, the present invention provides antibodies that enhance the generation of activated blood coagulation factor VIII. The antibodies enhance the cleavage of blood coagulation factor VIII at the Arg of position 372 and suppress the cleavage at the Arg of position 336 by recognizing and binding to the A2 domain of blood coagulation Factor VIII. Such antibodies are expected to be useful in preventing or treating diseases that develop or progress due to decrease or loss of the blood coagulation factor VIII activity, for example, hemophilia A, acquired hemophilia, and von Willebrand's disease.

Abstract: The present invention provides anti-aPC antibodies that suppress the inactivation of activated protein C (aPC), and uses thereof. The present inventors screened anti-aPC antibodies, and succeeded in isolating anti-aPC antibodies comprising the activity of suppressing aPC inactivation in blood. The antibodies of the present invention can be used to maintain aPC activity by suppressing aPC inactivation, and can thus be used to sustain aPC bioactivities, such as the activity of suppressing activation of the blood coagulation system, and anti-inflammatory activity. In addition, the present invention provides uses of the antibodies of the present invention in aPC therapy for diseases such as thrombosis and sepsis. The therapeutic effect of aPC can be prolonged in treatment that uses aPC administration by allowing an antibody of the present invention to bind with aPC. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.

Abstract: The present invention provides anti-aPC antibodies that suppress the inactivation of activated protein C (aPC), and uses thereof. The present inventors screened anti-aPC antibodies, and succeeded in isolating anti-aPC antibodies comprising the activity of suppressing aPC inactivation in blood. The antibodies of the present invention can be used to maintain aPC activity by suppressing aPC inactivation, and can thus be used to sustain aPC bioactivities, such as the activity of suppressing activation of the blood coagulation system, and anti-inflammatory activity. In addition, the present invention provides uses of the antibodies of the present invention in aPC therapy for diseases such as thrombosis and sepsis. The therapeutic effect of aPC can be prolonged in treatment that uses aPC administration by allowing an antibody of the present invention to bind with aPC. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.

Abstract: A multilayered coil is formed by inserting insulating paper 13 having either a pressure sensitive adhesive or an adhesive disposed on both faces thereof into at least one place between thin coil layers and then magnetic cores 15 are mounted to the multilayered coil from above and below. Thus, a thin transformer for a switching power supply is provided, in which variation in distance between coil 11 and coil 12, of which one is disposed over the other, variation in distance of coil 11 and coil 12 from magnetic core 15 and the like are suppressed.

Abstract: A multilayered coil is formed by inserting insulating paper 13 having either a pressure sensitive adhesive or an adhesive disposed on both faces thereof into at least one place between thin coil layers and, then, magnetic cores 15 are mounted to the multilayered coil from above and below.

Abstract: A method for forming a ceramics film on the surface of a substrate comprises performing spark discharge in an electrolytic bath, wherein the electrolytic bath comprises an aqueous solution of a water-soluble or colloidal silicate and/or an oxyacid salt to which ceramics fine particles and/or specific fine particles are dispersed and the spark discharge is carried out in the electrolytic bath while ensuring the suspended state of the ceramics particles and/or the specific fine particles in the electrolytic bath. The method makes it possible to effectively form, on the surface of a metal substrate, ceramics films having a variety of color tones as well as excellent insulating properties and hardness. Moreover, it further makes it possible to effectively form a composite ceramics film having excellent wear resistance on the surface of a metal substrate.