Abstract: A strong pressure and a strong shearing force are exerted to a mixture, constituted of two kinds or more of powder materials including a drug powder, while causing the mixture to pass between a press section (26) of a press head (24) and a receiving surface (25) of a cylindrical rotator (23), thereby combining the drug powder with the other powder material. For example, at least one of a drug and a biocompatible polymer is made into a nano particle whose average particle diameter is less than 1000 nm, and the nano particle is made into a composite in accordance with a dry mechanical particle combining method, so as to form a polymer nano composite particle. Thus, it is possible to produce a composite particle, which contains a drug under a stable condition, in a short time, and it is possible to remarkably improve its handling property without losing advantages of the nano particle.

Abstract: Liquid material is caused to freeze as a molded frozen body in a cylindrical form after the shape of the tubular inner wall surface of the freeze-drying apparatus, wherein the moisture content of the molded frozen material is sublimated under the vacuum to freeze-dry the material in the apparatus. A discharge port is defined at the lower end side of the tube, and jet nozzles are disposed, in the inner wall surface of the tube, for ejecting compressed air or gas toward the inner bore of the tube. The molded frozen body of the liquid material as freeze-dried is crushed and pulverized within the tube, by jet current ejected from jet nozzles.

Abstract: Desiccated bulk of liquid material, which has completed its freezing and desiccation in a freeze-drying apparatus, is subjected to pulverization within the machine body of a freeze-drying apparatus.