Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Abstract: An endoscope includes a insertion tube which is inserted into a human body, an imaging device, an object optical system which forms image on the imaging device, a detachable unit accommodating the imaging device and the object optical system. The detachable unit is detachably mounted to a mounting portion of the insertion tube. At least one first contact is provided to the detachable unit. At least one second contact is provided to the mounting portion. The first and second contacts are electrically connected when the detachable unit is mounted to the mounting portion. A waterproof arrangement is provided to prevent water from entering a connecting potion of the first and second contacts.

Abstract: A ceramic device providing an environment for the promotion and formation of new bone. The ceramic device is made of a sinter of calcium phosphate compound, containing a plurality of perfect spherical pores whose diameter ranges from 10-450 .mu.m to provide a suitable environment for the formation of new bone. A plurality of micro pores is included whose diameter ranges from 0.01-0.5 .mu.m which surrounds the perfect spherical pores to interconnect the perfect spherical pores with an outer surface of the ceramic device with the micro pores interconnecting with each other.

Abstract: An implant member is provided with at least one projection on its outer surface. Biological fusion with newly formed bony tissues is facilitated by permitting the projections to establish a small clearance between the implant and the surrounding bone.

Abstract: An upper structure for an artificial apatite dental root is disclosed. The structure includes inner and outer crowns having a buffer element placed therebetween. The buffer element serves as a satisfactory substitute for the periodontal membrane of a natural tooth.

Abstract: Prosthetic teeth and bones having superior affinity for the living body and having a compression strength of about 4.times.10.sup.-3 kg/cm.sup.2 or higher and a flexural strength of about 2.7.times.10.sup.3 kg/cm.sup.2 or higher, which comprise a composite material comprising(a) a sufficiently fine powder having an average particle size of about 2 .mu.m or less comprising at least 50% by weight of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2 and not more than about 50% by weight of at least one additive selected from the group consisting of Ca.sub.3 (PO.sub.4).sub.2, AlPO.sub.4, Al.sub.2 O.sub.3, AlF.sub.3, SiO.sub.2, Mg(PO.sub.4).sub.2, and the fluorides, chlorides and oxides of Li, Na, K, Mg and Ca, and(b) at least one fibrous material having the coefficient of thermal expansion nearly equal to or slightly lower than that of the hydroxy-apatite selected from the group consisting of fibers, fine filaments and metal whiskers, ceramics or glass,said fibrous material being present at least 50 .mu.

Abstract: A sintered apatite body obtained by molding and sintering an apatite powder, Ca.sub.5 (PO.sub.4).sub.3 OH, containing 0.01 to 20% by weight of (Ca,Mg).sub.3 (PO.sub.4).sub.2. The sintered apatite body has high mechanical strength and good affinity with living tissues and cells, and is suitable as medical implant materials such as prosthetic teeth or bones.

Abstract: A sintered apatite body obtained by molding and sintering an apatite powder, Ca.sub.5 (PO.sub.4).sub.3 OH, containing 0.01 to 20% by weight of (Ca,Mg).sub.3 (PO.sub.4).sub.2. The sintered apatite body has high mechanical strength and good affinity with living tissues and cells, and is suitable as medical implant materials such as prosthetic teeth or bones.