Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Abstract: A superior-limb arteriostenosis evaluating apparatus, including a superior-limb pulse-wave detecting device which detects a superior-limb pulse wave produced from an artery of at least one of a left superior limb and a right superior limb of a living subject, an inferior-limb pulse-wave detecting device which detects an inferior-limb pulse wave produced from an artery of at least one of a left inferior limb and a right inferior limb of the subject, and an arteriostenosis judging device for judging whether the artery of at least one of the left and right superior limbs has an arteriostenosis, based on a phase difference between the superior-limb pulse wave detected by the superior-limb pulse-wave detecting device and the inferior-limb pulse wave detected by the inferior-limb pulse-wave detecting device.

Abstract: An arteriosclerosis-degree evaluating apparatus, including a blood-pressure measuring device which iteratively measures a blood pressure value of a living subject, a pulse-wave-propagation-velocity-related-information obtaining device which iteratively obtains, at substantially a same time as a time when the blood-pressure measuring device measures each blood pressure value of the living subject, a piece of pulse-wave-propagation-velocity-related information that is related to a velocity at which a pulse wave propagates through an artery of the subject, and an output device which outputs a change of the pieces of pulse-wave-propagation-velocity-related information iteratively obtained by the pulse-wave-propagation-velocity-related-information obtaining device, relative to a change of the blood pressure values iteratively measured by the blood-pressure measuring device.

Abstract: An arteriosclerosis-degree evaluating apparatus, including a blood-pressure measuring device which iteratively measures a blood pressure value of a living subject, a pulse-wave-propagation-velocity-related-information obtaining device which iteratively obtains, at substantially a same time as a time when the blood-pressure measuring device measures each blood pressure value of the living subject, a piece of pulse-wave-propagation-velocity-related information that is related to a velocity at which a pulse wave propagates through an artery of the subject, and an output device which outputs a change of the pieces of pulse-wave-propagation-velocity-related information iteratively obtained by the pulse-wave-propagation-velocity-related-information obtaining device, relative to a change of the blood pressure values iteratively measured by the blood-pressure measuring device.

Abstract: An inflatable cuff for being wound and inflated around a body portion of a living subject to press the body portion in measuring a blood pressure of the subject, the cuff comprising: an inflatable bag; and an inner sheet member and an outer sheet member which are positioned inside and outside the inflatable bag, respectively, when the cuff is wound around the body portion of the subject; wherein at least a portion of the inner sheet member that is positioned inside the inflatable bag includes at least two layers which are separate from, and superposed on, each other.

Abstract: An apparatus for preventing a venous thromboembolism of a living subject, including an inflatable cuff which is adapted to be wound around a body portion of the subject and applies a pressing pressure to the body portion so as to press the body portion and thereby prevent the venous thromboembolism; a blood-pressure-relating-information obtaining device which obtains blood-pressure-relating information which changes corresponding to blood pressure of the subject; a pressing-pressure determining device for determining the pressing pressure of the inflatable cuff, based on the blood-pressure-relating information obtained by the blood-pressure-relating-information obtaining device, according to a prescribed relationship between pressing pressure and blood-pressure-relating information, in which the pressing pressure increases as the blood pressure corresponding to the blood-pressure-relating information increases; and a pressing device which operates the inflatable cuff to apply the pressing pressure determined

Abstract: An inflatable cuff for being wound and inflated around a body portion pressing a body portion of a living subject to press the body portion in measuring a blood pressure of the subject, the cuff comprising: an inflatable bag which is located in a portion of the cuff in a lengthwise direction thereof and a connector which is attached to a portion of the inflatable bag that is distant, by a predetermined distance, from a distal end of the cuff in a widthwise direction thereof, and which is adapted to connect the inflatable bag to a gas-supply pipe to supply a pressurized gas from the pipe to the inflatable bag.

Abstract: An inflatable cuff for being wound and inflated around a body portion of a living subject to press the body portion in measuring a blood pressure of the subject, the cuff comprising: an inflatable bag; and an inner sheet member and an outer sheet member which are positioned inside and outside the inflatable bag, respectively, when the cuff is wound around the body portion of the subject; wherein at least a portion of the inner sheet member that is positioned inside the inflatable bag includes at least two layers which are separate from, and superposed on, each other.

Abstract: A blood pressure monitor system, including a pulse wave detecting device detecting a pulse wave produced from an artery of a living subject, a blood pressure measuring device including a pressing device, for measuring a blood pressure of the subject by pressing a body portion of the subject with the pressing device, a relationship determining device determining a relationship between blood pressure and pulse wave magnitude, based on a pulse wave magnitude detected by the pulse wave detecting device and a blood pressure value measured by the blood pressure measuring device, a blood pressure monitor device continuously determining, according to the relationship, blood pressure values of the subject based on magnitudes of the pulse wave detected by the pulse wave detecting device, the relationship determining device updating the relationship at intervals of time, based on blood pressure values measured by the blood pressure measuring device, a blood pressure variation determining device determining a variation o

Abstract: A pressure pulse wave transmitting sheet for being interposed between a skin surface of a living subject such as a patient and a pressure pulse wave sensor set on the skin surface in pressed contact therewith, the sensor having a press surface in which at least one pressure sensing element is provided and which is pressed against the skin surface so that the at least one pressure sensing element detects a pressure pulse wave transmitted from an artery of the subject underlying the skin surface, to the press surface via the sheet, the sheet being formed of an elastic material having a hardness substantially equal to a hardness of human being's skin.

Abstract: An improved blood pressure occlusion cuff which is easily attached to the patient's arm and which is comfortable for use over extended periods of time. The preferred embodiment of the invention blood pressure cuff comprises a flexible band, a buckle for releasably securing said band to a person's limb, structure for pressurizing said band to cause it to apply pressure to said limb and for sensing pressure variations related to the flow between said buckle and said limb when said band is secured to said limb.

Abstract: A fluorine-containing copolymer comprising monomeric units of:(a) tetrafluoroethylene,(b) 8 to 15% by weight of hexafluoropropene on the basis of the weight of the copolymer, and(c) 0.2 to 2% by weight of a fluoroalkyl vinyl ether of the formula:CF.sub.2 .dbd.CF--O--(CF.sub.2).sub.n --CF.sub.2 Xwherein X is hydrogen or fluorine, and n is an integer of 3 to 9, on the basis of the weight of the copolymer, which has good moldability and improved stress crack resistance and flex resistance when formed as an article such as a film.

Abstract: A copolymer comprising monomeric units derived from ethylene, tetrafluoroethylene and a fluorine-containing vinyl monomer which provides the copolymer with side chains having at least one carbon atom, wherein the molar ratio of tetrafluoroethylene and ethylene is from 62:38 to 90:10 and the content of the fluorine-containing vinyl monomer is from 0.1 to 10% by mole based on the total number of mole of ethylene and tetrafluoroethylene, which has improved flexibility and better flame retardance.

Abstract: A laminated rubber stopper comprising a head portion and a leg portion which is to be inserted in an opening of a vessel, wherein at least a leg portion is laminated with a film of a copolymer of tetrafluoroethylene, ethylene and at least one fluorine-containing vinyl monomer copolymerizable with tetrafluoroethylene and ethylene, a molar ratio of tetrafluoroethylene and ethylene being from 62:38 to 90:10 and the amount of the fluorine-containing vinyl monomer being from 0.1 to 10% by mole based on the total number of mole of tetrafluoroethylene and ethylene, which has improved fitting with an opening of a vessel and sealing properties and can be produced with low failure rate.

Abstract: A fluorine-containing copolymer comprising monomeric units of(a) tetrafluoroethylene,(b) 8 to 15% by weight of hexafluoropropene on the basis of the weight of the copolymer, and(c) 0.2 to 2% by weight of a fluoroalkyl vinyl ether of the formula:CF.sub.2 .dbd.CF--O--(CF.sub.2).sub.n --CF.sub.2 X (I)wherein X is hydrogen or fluorine, and n is an integer of 3 to 9 on the basis of the weight of the copolymer, which has improved stress crack resistance, and flex resistance as well as good moldability.

Abstract: A fluorine-containing copolymer comprising monomeric units of(a) from 95.8 to 80% by weight of tetrafluoroethylene,(b) from 4 to 14% by weight of hexafluoropropene, and(c) from 0.2 to 6% by weight of perfluorovinyl ether of the formula: ##STR1## wherein n is an integer of 1 to 4, and m is an integer of 0 to 3, and having excellent stress crack resistance when formed into a molded article.

Abstract: A process for preparing a tetrafluoroethylene/fluoro(alkyl vinyl ether) copolymer comprising polymerizing tetrafluoroethylene and fluoro(alkyl vinyl ether) in an aqueous suspension system which comprises a mixed medium of water and a fluorohydrocarbon or a chlorofluorohydrocarbon in a volume ratio of from 1:1 to 10:1 at a temperature of from 0.degree. to 25.degree. C. in the presence of a polymerization initiator of the formula:[Cl(CF.sub.2).sub.n --COO].sub.2 (I)wherein n is an integer of 1 to 10, the copolymer obtained by the process having a small number of unstable terminal groups and excellent flex life.

Abstract: A process for preparing benzotrifluoride or derivatives thereof by contacting benzotrichloride or the corresponding derivatives with hydrogen fluoride in a gaseous phase in the absence of any catalyst, the contact being carried out in the presence of chlorine at an elevated temperature so as to accelerate the reaction rate.

Abstract: A process for preparing benzotrifluoride or derivatives thereof by contacting benzotrichloride or the corresponding derivative with hydrogen fluoride in a gaseous phase in the absence of any catalyst, the contact being carried out in the presence of chlorine at an elevated temperature so as to accelerate the reaction rate.

Abstract: A segmented polymer comprising a sequence of two or more polymer segments, an iodine atom liberated from an iodinated compound bonded at a terminal position of said sequence and a fragment of the iodinated compound from which at least one iodine atom has been removed bonded at another terminal position of said sequence, whereby said sequence intervenes between said iodine atom and said fragment, wherein adjacent polymer segments are different in steric configuration or monomeric composition, at least one of said polymer segments containing fluorine and each polymer segment having a molecular weight of not less than 10,000 but at least one polymer segment having a molecular weight of not less than 30,000. The polymer may contain additional moieties which originate from the monomers which constitute the polymer segments and from the iodinated compound, when the latter has a polymerizable double bond. The segmented polymers are prepared in a sequence of steps involving radical polymerization.