Patents by Inventor Tsuneo Okonogi
Tsuneo Okonogi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6255339Abstract: Compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof are disclosed. The compounds have progesterone receptor binding inhibitory activity and, hence, can be used as therapeutic and prophylactic agents for progesterone-related diseases. Specifically, they are useful as abortifacients, oral contraceptive pills, carcinostatic agents for breast cancer and ovarian cancer, therapeutic agents for endometriosis, meningioma, and myeloma, and therapeutic and prophylactic agents for osteoporosis and climacteric disturbance.Type: GrantFiled: July 21, 1998Date of Patent: July 3, 2001Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kenichi Kurihara, Rie Shinei, Kiyoshi Tanabe, Yasuo Yamamoto, Keiichi Ajito, Kaori Miyajima, Yuji Tabata, Shohei Yasuda, Kuniaki Tatsuta, Tsuneo Okonogi
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Patent number: 6077840Abstract: Compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof and a process for producing the same are disclosed. The compounds have progesterone receptor binding inhibitory activity and, hence, can be used as therapeutic and prophylactic agents for progesterone-related diseases. Specifically, they are useful as carcinostatic agents for breast cancer and ovarian cancer, therapeutic agents for hysteromyoma, endometriosis, meningioma, and myeloma, abortifacients, oral contraceptive pills, and therapeutic and prophylactic agents for osteoporosis and climacteric disturbance. ##STR1## wherein R.sup.1 represents alkyl or aralkyl; R.sup.Type: GrantFiled: June 18, 1999Date of Patent: June 20, 2000Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kenichi Kurihara, Rie Shinei, Yasushi Kurata, Yuji Tabata, Kiyoshi Tanabe, Tsuneo Okonogi
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Patent number: 6043217Abstract: Novel amide derivatives of amythiamicin are now provided, which are soluble in water and exhibit antibacterial activities, some of which exhibit an excellent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).Type: GrantFiled: August 20, 1997Date of Patent: March 28, 2000Assignee: Zaidan Hojin Biseibutsu Kagaku Kenyu KaiInventors: Yasuhiko Muraoka, Hironobu Iinuma, Tomio Takeuchi, Tsuneo Okonogi
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Patent number: 5602106Abstract: 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R.sup.2 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R.sup.3 represents a hydrogen atom or a straight-chain aliphatic acyl group having 2 to 4 carbon atoms; and R.sup.4 represents a hydrogen atom or a straight-chain aliphatic or aromatic acyl group having 1 to 10 carbon atoms;or a pharmaceutically acceptable salt thereof are disclosed.A novel process for producing these 16-membered macrolide derivatives is also disclosed.Type: GrantFiled: July 8, 1994Date of Patent: February 11, 1997Assignee: Meiji Seika Kaisha, Ltd.Inventors: Keiichi Ajito, Osamu Hara, Ken-ichi Kurihara, Nobue Kikuchi, Minako Araake, Akira Shimizu, Tsuneo Okonogi, Shigeharu Inouye, Seiji Shibahara
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Patent number: 5547978Abstract: The invention relates to derivatives of pyrrolidin-2-ylcarbonylheterocyclic compound of the general formula ##STR1## in which R.sup.1 represents C.sub.1-6 alkyl, C.sub.1-20 cycloalkyl, aryl or heteroaryl,R.sup.2 represents a heterocyclic compound selected from the group consisting of 2-thiazole, 2-oxazole, 2-imidazole, 2-pyrrole, 2-thiophene, 2-benzothiazole, 2-benzoxazole, 2-benzimidazole, 2-indole, 2-thiazolo[5,4-b]pyridine, 2-oxazolo[4,5-b]pyridine, 2-imidazo[4,5-b]pyridine, 5-thiazole, 2-thiazoline, 2-pyridine, 3-pyridine, 5-pyrimidine, 2-pyrazine, 2-triazole or 2-pyrazole wherein the heterocyclic compound may be unsubstituted or substituted independently with R.sup.4 or R.sup.5 wherein R.sup.4 and R.sup.5 are H, C.sub.1-5 alkyl, aryl or R.sup.4 and R.sup.Type: GrantFiled: November 23, 1994Date of Patent: August 20, 1996Assignee: Meiji Seika Kaisha, Ltd.Inventors: Burton G. Christensen, Takashi Egawa, Yasuyuki Ichimaru, Shokichi Ohuchi, Tsuneo Okonogi, Arthur A. Patchett, Seiji Shibahara, Seiji Tsutsumni
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Patent number: 5334723Abstract: A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.Type: GrantFiled: August 31, 1992Date of Patent: August 2, 1994Assignee: Meiji Seika Kaisha, Ltd.Inventors: Tsuneo Okonogi, Osamu Makabe, Yuichi Yamamoto, Osamu Itoh, Tsutomu Tsuruoka, Takayuki Usui, Seiji Shibahara, Kozo Nagaoka, Shigeharu Inouye, Nobuko Okada, Susumu Nishimura
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Patent number: 5332731Abstract: A new class of cephalosporin derivatives is provided, which is useful as antibacterial agent to be particularly suitable for oral administrations in mammals including man, and which is represented by general formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group; R.sup.2 is a hydrogen atom or an ester-forming group capable of being cleaved easily with an esterase existing in the digestive tracts; n is an integer of zero or 1; Z is a saturated heterocyclic group containing one or two oxygen atoms as the hetero-atoms with or without one or more lower alkyl substituents, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 6, 1990Date of Patent: July 26, 1994Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yuichi Yamamoto, Tsuneo Okonogi, Seiji Shibahara, Shigeharu Inoue
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Patent number: 5294705Abstract: An ester of 7-acylamido-3-acylthio-3- or -2-cephem-4-carboxylic acid represented by general formula (1) ##STR1## wherein R.sup.1 is an acyl group, R.sup.2 is a carboxyl-protecting group, R.sup.3 is a lower alkyl group, an aryl group or a substituted aryl group, or a mixture of two or more of said ester is used as the starting compound and is reacted wit a tertiary amine and also a secondary amine. Then the tertiary amine salt compound as formed as the reaction product is reacted with a compound of formula (4)R.sup.4 --X (4)wherein R.sup.4 is a lower alkyl group, a cycloalkyl group or a heterocyclic group or a heterocyclic group-substituted methyl group and X is a leaving group, whereby the desired ester of 7-acylamido-3-substituted thio-3-cephem-4-carboxylic acid of formula (5) ##STR2## can be produced preferentially, conveniently and efficiently.Type: GrantFiled: June 3, 1992Date of Patent: March 15, 1994Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yuichi Yamamoto, Tsuneo Okonogi, Seiji Shibahara, Shigeharu Inoue
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Patent number: 4970305Abstract: The crystalline dihydrochloride of a specific cephalosporin derivative is stable to heat and retains its antibacterial activity even after storage over long periods at high temperature. The crystalline dihydrochloride can be obtained by removing protective groups from the cephalosporin derivative wherein the amino group and carboxy groups are protected and then crystallizing the cephalosporin derivative from a hydrochloric acid aqueous solution. The crystalline dihydrochloride is useful for pharmaceutical preparations.Type: GrantFiled: September 28, 1989Date of Patent: November 13, 1990Assignee: Meiji Seika Kaisha, Ltd.Inventors: Tsuneo Okonogi, Yasushi Murai, Masahiro Onodera, Toshio Nishizuka, Yasuhiko Abat, Seiji Shibahara, Shigeharu Inouye
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Patent number: 4898858Abstract: New cephalosporin derivatives of a general formula (I) and non-toxic salts and non-toxic esters thereof are provided: ##STR1## (wherein R represents an acyclic or cyclic lower alkyl group having 1-6 carbon atoms, which may optionally be substituted by a halogen atom; the steric configuration as asterisked (*) includes an optical-active (R)-form or (S)-form or an optical-inactive (RS)-form; n is 0 or 1, n.sup.1 is 0 to 3, n.sup.2 is 0 to 3; and when n.sup.1 is 0, n.sup.2 is 3; when n.sup.1 is 1, n.sup.2 is 2; when n.sup.1 is 2, n.sup.2 is 1; when n.sup.1 is 3, n.sup.2 is 0).The new derivatives of the formula (I) and non-toxic salts and esters thereof have high bactericidal activity with broad antibacterial spectra, and these are useful as active ingredients in bactericides.Type: GrantFiled: November 10, 1986Date of Patent: February 6, 1990Assignees: Meiji Seika Kaisha Ltd., Susumu MitsuhashiInventors: Seiji Shibahara, Tsuneo Okonogi, Yasushi Murai, Toshiaki Kudo, Takashi Yoshida, Ken Nishihata, Shinichi Kondo
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Patent number: 4810702Abstract: Cephalosporin compounds having 2-(2-aminothiazol-4-yl)-2{(1S)-carboxyethoxyimino}acetyl group on the side chain at the 7-position thereof and 1-ethylpyridinium-4-ylthiomethyl group on the side chain at the 3-position thereof or non-toxic salts thereof are excellent antibacterial agents for mammals including human. The cephalosporin derivatives have low toxicity.Type: GrantFiled: December 11, 1987Date of Patent: March 7, 1989Assignee: Meiji Seika Kaisha, Ltd.Inventors: Seiji Shibahara, Tsuneo Okonogi, Yasushi Murai, Toshiaki Kudo, Takashi Yoshida, Ken Nishihata, Shinichi Kondo
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Patent number: 4785090Abstract: This is a class of antibacterial compounds of the formula: ##STR1## wherein Y is straight or branched alkyl or alkenyl chain, cycloalkanomethyl of 3-6 carbon atoms, each group being optionally substituted by halogen, or a group ##STR2## wherein n is 0 or an integer of 1-3, A is a group --COR.sup.3 wherein R.sup.3 is hydroxy, a group ##STR3## wherein R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or alkyl of 1-5 carbon atoms, a group ##STR4## or a 5- or 6-membered heterocyclic group containing nitrogen and/or sulfur, and R.sup.1 and R.sup.2, which may be the same or different, are hydrogen, alkyl of 1-5 carbon atoms, or R.sup.1 and R.sup.2 may be combined together to form cycloalkylidene of 3-5 carbon atoms, and Z is a group of the formula: ##STR5## wherein m is 0 or an integer of 3-5, R.sup.6 is hydrogen or alkyl of 1-3 carbon atoms, and R.sup.7, when m is an integer of 3-5, is alkyl of 1-5 carbon atoms, alkenyl, cyclopropyl, a group --(CH.sub.2).sub.Type: GrantFiled: February 21, 1985Date of Patent: November 15, 1988Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takashi Tsuruoka, Seiji Shibahara, Katsuyoshi Iwamatsu, Tsuneo Okonogi, Satoru Nakabayashi, Yasushi Murai, Hiroko Ogino, Kiyoaki Katano, Takashi Yoshida, Shigeharu Inoue, Shunzo Fukatsu, Shinichi Kondo
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Patent number: 4556513Abstract: Disclosed is a process for preparing antibiotic 1-oxadethiacephalosporins via diazo-species I: ##STR1## wherein: A is acyl; R.sup.1 is H or OCH.sub.3 ; and R.sup.2 is a protecting group.Type: GrantFiled: August 15, 1984Date of Patent: December 3, 1985Assignee: Meiji Seika Kaisha, Ltd.Inventors: Seiji Shibahara, Tsuneo Okonogi, Yasushi Murai, Shunzo Fukatsu, Taro Niida, Tadashi Wakazawa
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Patent number: 4534898Abstract: This invention relates to 1-oxa-1-dethia-cephalosporins which are useful as anti-biotics.Type: GrantFiled: July 20, 1983Date of Patent: August 13, 1985Assignee: Merck & Co., Inc.Inventors: Seiji Shibahara, Tsuneo Okonogi, Yasushi Murai, Shunzo Fukatsu, Tadashi Wakazawa, Taro Niida, Burton G. Christensen
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Patent number: 4497811Abstract: New 1-Oxadethiacephalosporins having a 3-loweralkyl thio group, and antibacterial compositions containing the same.Type: GrantFiled: July 1, 1983Date of Patent: February 5, 1985Inventors: Seiji Shibahara, Tsuneo Okonogi, Yasushi Murai, Shunzo Futkatsu, Taro Niida, Tadashi Wakazawa
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Patent number: 4472576Abstract: Disclosed is a process for preparing antibiotic 1-oxadethiacephalosporins via diazo-species I: ##STR1## wherein: A is acyl; R.sup.1 is H or OCH.sub.3 ; and R.sup.2 is a protecting group.Type: GrantFiled: December 3, 1982Date of Patent: September 18, 1984Assignee: Merck & Co., Inc.Inventors: Tadashi Wakazawa, Taro Niida, Shunzo Fukatsu, Yasushi Murai, Tsuneo Okonogi, Seiji Shibahara
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Patent number: 4418070Abstract: A 5-phenylthiazole derivative represented by the formula: ##STR1## wherein R represents a hydrogen atom, a lower alkyl group, a hydroxyl group, an amino group or a mercapto group, or a pharmaceutically acceptable salt thereof shows a cardiac effect and a low toxicity to a human or animal with little influence on atrium rhythms.Type: GrantFiled: February 4, 1982Date of Patent: November 29, 1983Assignee: Meiji Seika Kabushiki KaishaInventors: Tsuneo Okonogi, Shunzo Fukatsu, Mitsugu Hachisu, Hiroko Kawashima, Keiko Shitoh, Yasuharu Sekizawa