Abstract: Provided is a pharmaceutical composition including an active pharmaceutical ingredient, a toll-like receptor (TLR) agonist, a stimulator of interferon genes (STING) agonist, and a pharmaceutically acceptable carrier. Also provided are a method for inducing immune response and a method for treating or preventing cancer or an infectious disease, including administering an effective amount of the pharmaceutical composition to a subject in need thereof.

Abstract: A wireless electromagnetic thermotherapy apparatus applies a magnetic field on a needle for actuating heat generation thereby, and includes an excitation device and a detector device. The detector device includes a sensor unit that measures a temperature of the needle, a wireless charging unit that generates electrical energy in response to receipt of the magnetic field, a wireless transmitter that is powered by the electrical energy, and that transmits the measured temperature to the excitation device to enable the same to make a comparison between the measured temperature and a target temperature and to adjust an intensity of the magnetic field based on a result of the comparison.

Abstract: The present invention discloses a method for finding a cell nucleus of a target cell from a cell image, wherein the cell image includes the target cell and at least one variation cell, and the target cell includes cytoplasm and the cell nucleus. The method includes steps of: (a) processing the cell image via an image processor such that the cytoplasm, the cell nucleus and the variation cell have different shades of color; (b) demarcating the outlines of the cytoplasm, the cell nucleus and the variation cell; (c) calculating geometrical reference points of the outlines; (d) calculating the distances from the geometrical reference point of the cytoplasm outline to the geometrical reference point of the cell nucleus outline and to the geometrical reference points of the variation cell outlines; and (e) finding a specific geometrical reference point having a shortest distance to locate a specific outline corresponding to the specific geometrical reference point as the cell nucleus.

Abstract: A thermal treatment planning system including a processing device and an image display device is provided. The processing device obtains a medical condition setting, and performs a curve fitting operation according to a plurality of surgical situation information provided by a surgical parameters database and the medical condition setting, so as to obtain a surgical evaluation information corresponding to the medical condition setting. The image display device displays the surgical evaluation information. If the surgical evaluation information is reliable, the processing device optimizes the plurality of surgical context information in the surgical situation database based on the surgical evaluation information. In addition, a thermal treatment planning method is also provided.

Abstract: A medical image modeling system including a processing device, a display device, and an input device is provided. The processing device is configured to execute an image processing module to generate three-dimensional bone model data based on medical image data of a biological bone tissue. The display device is configured to simultaneously display a medical image and a three-dimensional bone model in the same operation interface according to the medical image data and the three-dimensional bone model data. The input device is configured to receive a parameter instruction, so that the processing device edits the three-dimensional bone model according to the parameter instruction by the image processing module. A medical image modeling method is also provided.

Abstract: A biosensor includes a microstrip resonator, a collection actuator disposed adjacent to and spaced from the microstrip resonator, a port unit connected to a network analyzer and coupled with the microstrip resonator, and a substrate. The microstrip resonator includes a collecting portion provided with an analyte-specific reagent (ASR) for binding an analyte in a suspension. The collection actuator and the microstrip resonator are applied with alternating current (AC) electric energy to induce AC electrokinetic stirring in the suspension for actuating the binding. The microstrip resonator resonates at a resonant frequency associated with the binding so that the analyte can be quantified.

Abstract: The present invention discloses a method for detecting whether cells are infected with human papillomavirus (HPV), and the method includes: (a) capturing a contour of a cell of a cell image, wherein the contour has a contour pixel thereon; (b) identifying a tangent of the contour pixel on the contour to define in relation to the tangent a first side and a second side opposite to the first side, wherein the first side indicates the intracellular region of the cell and the second side indicates the extracellular region of the cell; (c) calculating an optical parameter average of the plurality of pixels on both of the first side and the second side; and (d) determining whether the cell is infected with HPV based on whether the optical parameter average on the first side is smaller than that on the second side.

Abstract: The present invention discloses a method for finding a cell nucleus of a target cell from a cell image, wherein the cell image includes the target cell and at least one variation cell, and the target cell includes cytoplasm and the cell nucleus. The method includes steps of: (a) processing the cell image via an image processor such that the cytoplasm, the cell nucleus and the variation cell have different shades of color; (b) demarcating the outlines of the cytoplasm, the cell nucleus and the variation cell; (c) calculating geometrical reference points of the outlines; (d) calculating the distances from the geometrical reference point of the cytoplasm outline to the geometrical reference point of the cell nucleus outline and to the geometrical reference points of the variation cell outlines; and (e) finding a specific geometrical reference point having a shortest distance to locate a specific outline corresponding to the specific geometrical reference point as the cell nucleus.

Abstract: The present invention discloses a method for detecting whether cells are infected with human papillomavirus (HPV), and the method includes: (a) capturing a contour of a cell of a cell image, wherein the contour has a contour pixel thereon; (b) identifying a tangent of the contour pixel on the contour to define in relation to the tangent a first side and a second side opposite to the first side, wherein the first side indicates the intracellular region of the cell and the second side indicates the extracellular region of the cell; (c) calculating an optical parameter average of the plurality of pixels on both of the first side and the second side; and (d) determining whether the cell is infected with HPV based on whether the optical parameter average on the first side is smaller than that on the second side.

Abstract: An orthodontic bracket and an orthodontic assembly are provided. The orthodontic bracket includes a bottom base, a first sidewall, a second sidewall and two blocks. The bottom base has a first surface and a second surface opposite to each other. The first sidewall is disposed on the first surface. The second sidewall is disposed on the first surface and is opposite to the first sidewall. The blocks are disposed on the first surface between the first sidewall and the second sidewall. A bending space is defined and formed between the blocks, a first path is defined and formed between the first sidewall and the blocks, and a second path is defined and formed between the second sidewall and the blocks. An orthodontic wire is configured to be disposed in the first path or the second path, or to extend through the first path, the bending space and the second path.

Abstract: A device for enhancing induced magnetic field consequent for thermal ablation therapy includes a magnetic field generating unit, an annular support and a magnetic ring. The annular support is non-magnetic and non-electrically-conductive, and has two annular end faces and annular outer and inner walls. The magnetic field generating unit is fixed around and contacts the annular outer wall. The magnetic ring is magnetic, has a ring body confining a ring opening, fixed to one of the annular inner wall and the annular end faces, and extending around a common axial line that extends through the annular inner wall. The ring opening is smaller than the annular inner wall in dimension on a plane perpendicular to the common axial line.

Abstract: A magnetic excitation device for an electromagnetic thermal ablation apparatus includes a magnetic unit and two coil units. The magnetic unit has two magnetic induction ends that are spaced apart from each other. The coil units are respectively disposed around the magnetic induction ends. Each of the coil units has two connection parts connectible to an alternating electric power source for generating an alternating magnetic field.

Abstract: A magnetic adapter assembly for connection with at least one magnetic excitation device includes a magnetic adapter which includes an insulating housing having a plurality of connection portions facing in different directions, a magnetic unit disposed in the insulating housing and having a plurality of positioning grooves respectively aligned with the connection portions for allowing extension of the magnetic excitation device into one of the positioning grooves through a selected one of the connection portions, and at least one fastener for fastening together the magnetic excitation device and one of the connection portions.

Abstract: A thermal ablation needle of the present invention includes a magnetic section and a nonmagnetic section. The magnetic section includes a needle tip and a space that is spaced apart from the needle tip. The nonmagnetic section is connected to the magnetic section oppositely of the needle tip.

Abstract: A magnetic excitation system includes a magnetic excitation apparatus for generating a magnetic field, and an analyzing device including a detecting unit for detecting magnetic flux of the magnetic field, and a processing unit. The processing unit is configured to: determine a magnetic flux distribution associated with a target according to the magnetic flux; generate, according to the magnetic flux distribution, a simulated magnetic field distribution over the target before a magnetic induction needle is punctured into the target; and calculate, in real time, temperature and ablating range associated with the target based on the magnetic flux when the magnetic induction needle is punctured into the target.

Abstract: A thermal ablation needle assembly includes a hollow needle body and a thermal-detecting unit. The hollow needle body has a needle tip, a receiving space formed therein, and an extension opening opposite to the needle tip and communicating the receiving space with the external environment. The thermal-detecting unit includes two wires extending into the receiving space through the extension opening. Each wire has a first end portion adjacent to the needle tip and a second end portion opposite to the first end portion. The first end portions of the wires are connected to each other and establish a short circuit.

Abstract: A microstrip antenna structure is provided, which includes a substrate, a ring microstrip line and a signal transmission port. The substrate has opposite first and second surfaces. The ring microstrip line is disposed on the first surface of the substrate. The ring microstrip line has a short coupling gap ranged between 0.004?g and 0.06?g for forming a radiation bandwidth with high selectivity, where ?g represents a guided wavelength of an electromagnetic wave in the ring microstrip line corresponding to a center frequency of the radiation bandwidth. The signal transmission port is disposed on the second surface of the substrate. The signal transmission port penetrates through the substrate and is electrically connected to the ring microstrip line.

Abstract: The disclosure provides a thermotherapy needling instrument with tissue injection, including: a casing, an outer needle, an inner needle and a working needle. The casing has an inlet, an outlet and an inner channel. The outer needle is connected to the casing, and is in communication with the inner channel. The inner needle is disposed in the inner channel of the casing and the outer needle, and the inner needle has at least one opening. The at least one opening is in communication with the inner channel so that the cooling agent flows in circulation. The working needle is connected to the outer needle so as to receive the injectant for injection and tissue ablation. By using the thermotherapy needling instrument, when sampling or injection is required during thermotherapy, the injection efficacy can be achieved by withdrawing the inner needle only. Therefore, efficacy of tissue injection and ablation thermotherapy can be achieved.

Abstract: A deep magnetic field generating apparatus includes a first coil unit and a second coil unit. The second coil unit is connected with the first coil unit, and disposed around the first coil unit horizontally. Accordingly, the deep magnetic field generating apparatus can generate a desired deep magnetic field.

Abstract: A radiation generating apparatus includes a target base, a target, an electronic beam generating device, a tube, a tank, and a porous structure. The target is disposed on the target base. The electronic beam generating device is adapted to generate an electronic beam, and the electronic beam is emitted to the target to generate a radiation. The tube accommodates the target and the electronic beam generating device. The tank is connected to the target base and is accommodated by the tube. The porous structure is disposed in the tank and contacts the target base. A cooling fluid flows through the porous structure to dissipate the heat of the porous structure.