Abstract: Provided is a pharmaceutical composition including an active pharmaceutical ingredient, a toll-like receptor (TLR) agonist, a stimulator of interferon genes (STING) agonist, and a pharmaceutically acceptable carrier. Also provided are a method for inducing immune response and a method for treating or preventing cancer or an infectious disease, including administering an effective amount of the pharmaceutical composition to a subject in need thereof.

Abstract: A semiconductor package including a first semiconductor die, a second semiconductor die, a first insulating encapsulation, a dielectric layer structure, a conductor structure and a second insulating encapsulation is provided. The first semiconductor die includes a first semiconductor substrate and a through silicon via (TSV) extending from a first side to a second side of the semiconductor substrate. The second semiconductor die is disposed on the first side of the semiconductor substrate. The first insulating encapsulation on the second semiconductor die encapsulates the first semiconductor die. A terminal of the TSV is coplanar with a surface of the first insulating encapsulation. The dielectric layer structure covers the first semiconductor die and the first insulating encapsulation. The conductor structure extends through the dielectric layer structure and contacts with the through silicon via.

Abstract: The present invention discloses a combinational therapy for enhancing efficacy of immune checkpoint blockade for tumors with immune suppressive microenvironment. More specifically, this combination therapy involves the treatment of cancer through immune checkpoint inhibitors and CpG-oligodeoxynucleotides.

Abstract: The present invention discloses a combinational therapy for enhancing efficacy of immune checkpoint blockade for tumors with immune suppressive microenvironment. More specifically, this combination therapy involves the treatment of cancer through immune checkpoint inhibitors and CpG-oligodeoxynucleotides.

Abstract: A method of stimulating a TLR9-activated immune response or enhancing a TLR9-activated immune response to an antigen is disclosed herein. TLR9 is the cellular receptor for CpG-ODN, and current developed CpG-ODN has low activity to rabbit TLR9. Here, the method of stimulating TLR9-activated immune response by administering an effective amount of immunogenic composition comprising an antigen and a CpG-ODN comprising GACGTT or AACGTT motif was demonstrated to have potent immunostimulatory activity to rabbit TLR9, and capable of boosting a less toxic and potent antibody response in rabbits.

Abstract: A CpG-oligodeoxynucleotide (CpG-ODN) for inducing a TLR9 activated immune response, a TLR21 activated immune response or a combination thereof in a host is provided. The CpG-ODN includes one or more copies of the sequences of GTCGTT, one or more copies of the sequences of GTT and one or more copies of the sequences of TTTT, wherein at least one copy of the sequence of GTCGTT is encoded between the sequence of GTT and the sequence of TTTT. Further, an immunogenic composition including the CpG-ODN and a method of inducing immune response by the same are also provided.

Abstract: A CpG-oligodeoxynucleotide (CpG-ODN) for inducing a TLR9 activated immune response, a TLR21 activated immune response or a combination thereof in a host is provided. The CpG-ODN includes one or more copies of the sequences of GTCGTT, one or more copies of the sequences of GTT and one or more copies of the sequences of TTTT, wherein at least one copy of the sequence of GTCGTT is encoded between the sequence of GTT and the sequence of TTTT. Further, an immunogenic composition including the CpG-ODN and a method of inducing immune response by the same are also provided.

Abstract: An assembly of a gas injector and a ceiling is used in a film deposition apparatus for semiconductor processes. The assembly comprises a gas injector and a ceiling. The gas injector comprises a gas passage portion, a flow injection portion in communication with the gas passage portion, and a plurality of fixation portions disposed on the flow injection portion. The ceiling comprises an engagement portion which contains and is interlocked with the fixation portions.

Abstract: A method of stimulating a TLR9-activated immune response or enhancing a TLR9-activated immune response to an antigen is disclosed herein. TLR9 is the cellular receptor for CpG-ODN, and current developed CpG-ODN has low activity to rabbit TLR9. Here, the method of stimulating TLR9-activated immune response by administering an effective amount of immunogenic composition comprising an antigen and a CpG-ODN comprising GACGTT or AACGTT motif was demonstrated to have potent immunostimulatory activity to rabbit TLR9, and capable of boosting a less toxic and potent antibody response in rabbits.

Abstract: CpG-oligodeoxynucleotides (CpG-ODN), as potent immune stimuli developed for using as adjuvant in different species, are disclosed herein. TLR9 is the cellular receptor for CpG-ODN, and current developed CpG-ODN has low activity to rabbit TLR9. Here, a type of CpG-ODN containing a GACGTT or AACGTT motif in about 11-14 deoxynucleotides was demonstrated to have potent immunostimulatory activity to rabbit TLR9, and capable of boosting a less toxic and potent antibody response in rabbits.

Abstract: The invention relates to a display rear shell with waterproof and fireproof properties comprising a main layer of a pulp made from hardwood in an amount from 80% to 90% by weight of the main layer, a pulp waterproof composition in an amount from 5% to 15% by weight of the main layer, and a flame retardant in an amount of a remaining weight percentage by weight of the main layer, a fireproof layer and a waterproof layer, in place of a traditional plastic display rear shell using plastic materials for characteristics as waterproof, fireproof and light weight.

Abstract: A battery power system includes a number of battery modules. Each battery module includes a number of battery cells, a management circuit positioned at a first side of the battery module, and a heat source positioned at a second side of the battery module and opposite to the first side. The management circuit is electrically connected to and manages charging and discharging of the cells of the corresponding battery module. The heat source is thermally coupled to the cells of the corresponding battery module and dissipates heat generated by the cells of the corresponding battery module. The battery modules are arranged in two lines, and the first sides of the battery modules in one line are positioned adjacent to and face the first sides of the battery modules in another line.

Abstract: The invention relates to a display connector with a 4K image resolution. It primarily comprises a first connector, a second connector and a third connector. The present invention is a connector for a display to support high specification images with quad full high definition (QFHD). The third connector is used to connect an existing video playback device merely having the playback function of full high definition (FHD). Then the FHD image data is upscaled through an electrically connected image upscaling module of the first connector, and QFHD image signals with an ultra-high definition resolution is displayed through an electronic display device. Accordingly, the QFHD image signals with the ultra-high definition resolution can be displayed without upgrading the hardware of the player or computer so as to dramatically reduce the required cost of upgrading the hardware.

Abstract: A rotary lighting fixture having a speaker with a playback function is revealed herein, comprising a shell having an opening, a speaker fitted inside the shell, and an annular LED module having plural LEDs fitted at the opening of the shell for illumination and playback functions. In addition, the lighting fixture also combines with a power supply base with a rotary function embedded in a ceiling and a wall for substantially saving space in use thereof, promoting interior designs by its aesthetic appearance and adjusting angles of incidence from the LEDs as desired.

Abstract: The invention relates to a LED display device. Primarily, it comprises a liquid crystal display, a shell, a plurality of lighting modules and two reflective layers. The present invention is a liquid crystal display device which uses the light emitting diode to combine with polymethylmethacrylate (PMMA) as a lighting module. The secondary lens theory composed of different refractive index between air and PMMA and the angle of the reflective layers on the inner surface of the side planes are used to effectively increase the refracted angle of light emitted from the light emitting diode and the distance of the mixed light and to effectively reach the advantages of thinner liquid crystal display and lower power consumption.

Abstract: A battery pack includes a housing, a number of battery cells received in the housing, and an electrical connection plate module for connecting the battery cells together. The housing defines a number of heat dissipating grooves. The battery pack further includes a number of electrically-insulated heat conductive pads received in the heat dissipating grooves and at least one heat conductive plate. The heat conductive plate forms a number of first protrusions and is mounted on the housing. The first protrusions extend into the heat dissipating grooves pressing the electrically-insulated heat conductive pads close to the electrical connection plate module.

Abstract: A battery pack includes a housing, a number of battery cells received in the housing, and an electrical connection plate module for connecting the battery cells together. The housing defines a number of wedge-shaped grooves. The battery pack further includes a number of electrically insulated heat conductive pads received in the wedge-shaped grooves and at least one heat conductive plate. The heat conductive plate forms a number of first wedge-shaped protrusions and is mounted on the housing. The first wedge-shaped protrusions cooperate with the wedge-shaped grooves to press the electrically-insulated heat conductive pads on the electrical connection plate module.

Abstract: The invention relates to a display connector with a 4K image resolution. It primarily comprises a first connector, a second connector and a third connector. The present invention is a connector for a display to support high specification images with quad full high definition (QFHD). The third connector is used to connect an existing video playback device merely having the playback function of full high definition (FHD). Then the FHD image data is upscaled through an electrically connected image upscaling module of the first connector, and QFHD image signals with an ultra-high definition resolution is displayed through an electronic display device. Accordingly, the QFHD image signals with the ultra-high definition resolution can be displayed without upgrading the hardware of the player or computer so as to dramatically reduce the required cost of upgrading the hardware.

Abstract: A battery module includes a base, a battery assembly supported by the base and comprising one or more battery cells, and a heat dissipation unit for dissipating heat created by the one or more battery cells. The heat dissipation unit comprises one or more heat-conducting elements to transmit the heat from the one or more battery cells. Each of the one or more heat-conducting elements comprises a plurality of branches concentrated at a substantially middle portion to form a fixing portion and extend away from each other at two ends of each branch. Each of the one or more battery cells is in contact with the branches of at least one of the one or more heat-conducting elements.