Abstract: The present invention provides an oral self micro-emulsifying pharmaceutical composition of a hydrophilic drug or a pharmaceutically acceptable salt thereof which, in addition to the hydrophilic drug, one or more solvents for solving the hydrophilic drug to form a drug-solvent solution and a surfactant system, further comprises one or more hydrophilic carrier which are compatible with said drug-solvent solution and the surfactant system. The oral self micro-emulsifying pharmaceutical composition of the invention exhibits comparative bioavailability to that of the hydrophilic drug through injection and is stable during storage. A method for preparing the oral self micro-emulsifying pharmaceutical composition is also provided.

Abstract: A vibration assistant polishing module which comprises a polishing disk, a workpiece carrier tray, a linear guide way mechanism, a linkage, a motor and an adjustable eccentricity mechanism. The linear guide way mechanism includes a slide, a guide seat and a guide rod. The slide is pivot jointed with workpiece carrier tray and engaged in guide seat. The adjustable eccentricity mechanism comprises a base which is connected with a power shaft of the motor, and a pivot shaft of base and linkage is eccentric to the power shaft. The power shaft drives the base rotating and the linkage swinging eccentrically, and the slide moves linearly according to the limitation from guide seat, and a horizontal radial vibration and low frequency vibration is generated on the workpiece carrier tray, so the low frequency vibration is generated on the surface of the workpiece which is touched with the polishing disk.

Abstract: A vibration assistant polishing module which comprises a polishing disk, a workpiece carrier tray, a linear guide way mechanism, a linkage, a motor and an adjustable eccentricity mechanism. The linear guide way mechanism includes a slide, a guide seat and a guide rod. The slide is pivot jointed with workpiece carrier tray and engaged in guide seat. The adjustable eccentricity mechanism comprises a base which is connected with a power shaft of the motor, and a pivot shaft of base and linkage is eccentric to the power shaft. The power shaft drives the base rotating and the linkage swinging eccentrically, and the slide moves linearly according to the limitation from guide seat, and a horizontal radial vibration and low frequency vibration is generated on the workpiece carrier tray, so the low frequency vibration is generated on the surface of the workpiece which is touched with the polishing disk.

Abstract: The present invention provides an oral self micro-emulsifying pharmaceutical composition of a hydrophilic drug or a pharmaceutically acceptable salt thereof which, in addition to the hydrophilic drug, one or more solvents for solving the hydrophilic drug to form a drug-solvent solution and a surfactant system, further comprises one or more hydrophilic carrier which are compatible with said drug-solvent solution and the surfactant system. The oral self micro-emulsifying pharmaceutical composition of the invention exhibits comparative bioavailability to that of the hydrophilic drug through injection and is stable during storage. A method for preparing the oral self micro-emulsifying pharmaceutical composition is also provided.

Abstract: A de-noise circuit and a de-noise method for differential signals and a chip for receiving differential signals are provided. The de-noise circuit includes a filter and a register. Both the filter and the register are disposed in the chip. The chip receives a differential signal through a first input terminal and a second input terminal. The filter is coupled between the first input terminal and the second input terminal of the chip. The filter filters out noises in the differential signal. The filter includes at least one filter unit. Each filter unit has at least one resistance value or at least one capacitance value. The register is coupled to the filter. The register receives and stores a control value. The register controls the resistance value or the capacitance value of at least one of the filter units based on the control value.

Abstract: A controlled release carvedilol formulation for less frequent, preferably once daily administration is described. The controlled release formulation comprises a therapeutically effective amount of carvedilol or a pharmaceutically acceptable salt thereof, a matrix forming polymer, a solubility enhancer and a pharmaceutically acceptable carrier. In one embodiment, a controlled release formulation having a therapeutically effective amount of carvedilol is contained in two or more subunits having different release profiles. The controlled release formulation is usable in the treatment and/or prophylaxis of one or more conditions such as cardiovascular disorders.

Abstract: A de-noise circuit and a de-noise method for differential signals and a chip for receiving differential signals are provided. The de-noise circuit includes a filter and a register. Both the filter and the register are disposed in the chip. The chip receives a differential signal through a first input terminal and a second input terminal. The filter is coupled between the first input terminal and the second input terminal of the chip. The filter filters out noises in the differential signal. The filter includes at least one filter unit. Each filter unit has at least one resistance value or at least one capacitance value. The register is coupled to the filter. The register receives and stores a control value. The register controls the resistance value or the capacitance value of at least one of the filter units based on the control value.

Abstract: A controlled release carvedilol formulation for less frequent, preferably once daily administration is described. The controlled release formulation comprises a therapeutically effective amount of carvedilol or a pharmaceutically acceptable salt thereof, a matrix forming polymer, a solubility enhancer and a pharmaceutically acceptable carrier. In one embodiment, a controlled release formulation having a therapeutically effective amount of carvedilol is contained in two or more subunits having different release profiles. The controlled release formulation is usable in the treatment and/or prophylaxis of one or more conditions such as cardiovascular disorders.

Abstract: A pulse width (PW) digitizer comprises a current pump, a capacitor, a quantizer, a feedback controller, and a digital filter. The current pump provides a current signal in response to a PW signal. The capacitor obtains a voltage signal in response to the current signal. The quantizer obtains a digital signal in response to the voltage signal. The feedback controller determines a feedback PW signal in response to the digital signal. The feedback PW signal is fed back to the current pump for controlling the current signal converging to a specific value and controlling the digital signal switching between a first code and a second code. The digital filter counts times that the digital signal indicating the first code/the second code and accordingly obtains the PW of the PW signal.

Abstract: A pulse width (PW) digitizer comprises a current pump, a capacitor, a quantizer, a feedback controller, and a digital filter. The current pump provides a current signal in response to a PW signal. The capacitor obtains a voltage signal in response to the current signal. The quantizer obtains a digital signal in response to the voltage signal. The feedback controller determines a feedback PW signal in response to the digital signal. The feedback PW signal is fed back to the current pump for controlling the current signal converging to a specific value and controlling the digital signal switching between a first code and a second code. The digital filter counts times that the digital signal indicating the first code/the second code and accordingly obtains the PW of the PW signal.

Abstract: The present invention provides an oral self micro-emulsifying pharmaceutical composition of a hydrophilic drug or a pharmaceutically acceptable salt thereof which, in addition to the hydrophilic drug, one or more solvents for solving the hydrophilic drug to form a drug-solvent solution and a surfactant system, further comprises one or more hydrophilic carrier which are compatible with said drug-solvent solution and the surfactant system. The oral self micro-emulsifying pharmaceutical composition of the invention exhibits comparative bioavailability to that of the hydrophilic drug through injection and is stable during storage. A method for preparing the oral self micro-emulsifying pharmaceutical composition is also provided.

Abstract: A composite optical film including a base and an optical-field-modulation microstructure layer is provided. The base has a light incident surface and a light emitting surface, wherein the light incident surface and the light emitting surface are correspondingly disposed. The optical-field-modulation microstructure layer disposed on the light emitting surface has a first prism column set and a second prism column set, wherein the first prism column set has a plurality of first prism columns arranged in parallel and extended along a first direction, and the second prism column set has a plurality of second prism columns arranged in parallel and extended along a second direction. The first prism column set and the second prism column set are disposed across each other, and at least one of the first prism column set and the second prism column set has a smooth curve top.

Abstract: A frequency shift keying modulator having sigma-delta modulated phase rotator is disclosed, which includes a phase-locked loop for generating a voltage-controlled signal; a multi-phase generator for receiving the voltage-controlled signal and generating N phase-shift signals having same frequency according to the voltage-controlled signal, the N phase-shift signals having a same phase shift between the phase-shift signals adjacent to each other; a sigma-delta modulator for receiving transmission data and randomly outputting a modulation bit at a modulation clock according to the transmission data; and a phase rotator for receiving the N phase-shift signals and selectively outputting one of the N phase-shift signals and a frequency-divided signal according to the modulation bit, wherein the frequency of the frequency-divided signal is 1 / ( 1 + n N ) of the frequency of any one of the N phase-shift signals.

Abstract: A frequency shift keying modulator having sigma-delta modulated phase rotator is disclosed, which includes a phase-locked loop for generating a voltage-controlled signal; a multi-phase generator for receiving the voltage-controlled signal and generating N phase-shift signals having same frequency according to the voltage-controlled signal, the N phase-shift signals having a same phase shift between the phase-shift signals adjacent to each other; a sigma-delta modulator for receiving transmission data and randomly outputting a modulation bit at a modulation clock according to the transmission data; and a phase rotator for receiving the N phase-shift signals and selectively outputting one of the N phase-shift signals and a frequency-divided signal according to the modulation bit, wherein the frequency of the frequency-divided signal is 1/(1+n/N) of the frequency of any one of the N phase-shift signals.

Abstract: A light guide lens includes a lens body having a light incidence surface and a light emission surface, a plurality of refraction structures formed on the light incidence surface, and a plurality of reflection structures formed on the light emission surface. The refraction structures send incoming light rays to the light emission surface by refraction. Each of the refraction structures turns incoming light rays coming in all directions into refracted parallel light rays. The refracted parallel light rays arriving from the refraction structures reflect off the corresponding reflection structures and then laterally exit the lens body. The refracted parallel light rays arriving from each of the refraction structures travel to a corresponding one of the reflection structures, such that eventually the incoming light rays exit laterally. The present invention further provides a light emitting diode package structure having the light guide lens.

Abstract: A light guide lens includes a lens body having a light incidence surface and a light emission surface, a plurality of refraction structures formed on the light incidence surface, and a plurality of reflection structures formed on the light emission surface. The refraction structures send incoming light rays to the light emission surface by refraction. Each of the refraction structures turns incoming light rays coming in all directions into refracted parallel light rays. The refracted parallel light rays arriving from the refraction structures reflect off the corresponding reflection structures and then laterally exit the lens body. The refracted parallel light rays arriving from each of the refraction structures travel to a corresponding one of the reflection structures, such that eventually the incoming light rays exit laterally. The present invention further provides a light emitting diode package structure having the light guide lens.

Abstract: A light guide plate is provided. The light guide plate has a transparent substrate having a first optical face and a second optical face, a first micro structure and a second micro structure respectively corresponding to the first optical face and the second optical face. The first micro structure has a tunable composite optical effect with light collection and diffusion functions so as to increase brightness and evenness of exit light. The second micro structure has a design of curved face to destroy total reflection of light, such that bright lines can be effectively prevented from occurrence by avoiding the light outputting from the direction over against the first optical face. A back light unit having the light guide plate is further provided in the present invention.

Abstract: An apparatus for homogeneously distributing lights includes a light guide plate, an incidence microstructure and an emergence microstructure. The incidence microstructure is arranged on a surface of the light guide plate and opposite to a light source. The emergence microstructure is arranged on a surface of the light guide plate opposite to the incidence microstructure. The lights emitted by the light source pass through said apparatus thereby being homogenously distributed. Thus the manufacture costs are lowered, and the light source utilization ratio is increased.

Abstract: An apparatus for homogeneously distributing lights includes a light guide plate, an incidence microstructure and an emergence microstructure. The incidence microstructure is arranged on a surface of the light guide plate and opposite to a light source. The emergence microstructure is arranged on a surface of the light guide plate opposite to the incidence microstructure. The lights emitted by the light source pass through said apparatus thereby being homogenously distributed. Thus the manufacture costs are lowered, and the light source utilization ratio is increased.

Abstract: The present invention discloses a dual-lens hybrid diffractive/refractive imaging system comprising: a first lens including a concave surface and a convex surface; and the second lens including a convex surface and a concave surface. The concave surface of the first lens is an objective surface facing the object. The convex surface faces the convex surface of the second lens, while the concave surface of the second lens faces the charge-coupled device (CCD) through a filter. Any surface of the first lens and the second lens is spheric or aspheric. Moreover, the imaging system comprises at least one diffractive surface, referred to as a hybrid diffractive/refractive surface, formed on any surface of the two lenses. Therefore, aberration is eliminated and image quality is improved without increasing the number of lenses.