Patents by Inventor Tsung-Hui Li

Tsung-Hui Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors
    Patent number: 11407757
    Abstract: Disclosed are compounds of formula (I) below and tautomers, stereoisomers, isotopologues, or pharmaceutically acceptable salts thereof: in which each of variables R1, ring A, L, W, V, and G is defined herein. Also disclosed are a method for treating disease or disorder mediated by Tyro3, Axl, and/or Mer kinase with a compound of formula (I) or a tautomer, stereoisomer, isotopologue, or salt thereof and a pharmaceutical composition containing same.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: August 9, 2022
    Assignee: Development Center for Biotechnology
    Inventors: Shih-Chieh Yen, Chu-Bin Liao, Hui-Chen Wang, Po-Ting Chen, Yu-Chih Pan, Tsung-Hui Li, Bo-Rong Chen, Shian-Yi Chiou
  • HETEROCYCLE COMPOUNDS AS TYRO3, AXL AND MERTK (TAM) FAMILY OF RECEPTOR TYROSINE KINASE INHIBITORS
    Publication number: 20210009597
    Abstract: Disclosed are compounds of formula (I) below and tautomers, stereoisomers, isotopologues, or pharmaceutically acceptable salts thereof: in which each of variables R1, ring A, L, W, V, and G is defined herein. Also disclosed are a method for treating disease or disorder mediated by Tyro3, Axl, and/or Mer kinase with a compound of formula (I) or a tautomer, stereoisomer, isotopologue, or salt thereof and a pharmaceutical composition containing same.
    Type: Application
    Filed: December 26, 2018
    Publication date: January 14, 2021
    Applicant: Development Center for Biotechnology
    Inventors: Shih-Chieh YEN, Chu-Bin LIAO, Hui-Chen WANG, Po-Ting CHEN, Yu-Chih PAN, Tsung-Hui LI, Bo-Rong CHEN, Shian-Yi CHIOU
  • Tubulin inhibitors and methods of using the same
    Patent number: 8883793
    Abstract: Compounds represented by the formula (I) or pharmaceutically acceptable salts thereof: R2—Y—Z-Q-A-R1??Formula (I) wherein R1, R2, Y, Z, Q, and A are as defined. These compounds are inhibitors of tubulin polymerization by binding at colchicines binding site and are useful in the treatment of tumors or mitotic diseases such as cancers, gout, and other conditions associated with abnormal cell proliferation.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: November 11, 2014
    Assignee: Development Center for Biotechnology
    Inventors: Meng-Hsin Chen, Shih-Hsien Chuang, Yi-Jen Chen, Lien-Hsiang Chang, Tsung-Hui Li, Ching-Hui Chen, Win-Yin Wei
  • NOVEL TUBULIN INHIBITORS AND METHODS OF USING THE SAME
    Publication number: 20120172374
    Abstract: Compounds represented by the formula (I) or pharmaceutically acceptable salts thereof: R2—Y—Z-Q-A-R1??Formula (I) wherein R1, R2, Y, Z, Q, and A are as defined. These compounds are inhibitors of tubulin polymerization by binding at colchicines binding site and are useful in the treatment of tumors or mitotic diseases such as cancers, gout, and other conditions associated with abnormal cell proliferation.
    Type: Application
    Filed: December 29, 2011
    Publication date: July 5, 2012
    Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: Meng-Hsin Chen, Shih-Hsien Chuang, Yi-Jen Chen, Lien-Hsiang Chang, Tsung-Hui Li, Ching-Hui Chen, Win-Yin Wei