Abstract: The present invention provides a method for producing an active ingredient for a rivastigmine free base transdermal patch having preparing a rivastigmine free base; and adding an acidic substance to the rivastigmine free base and subjecting the acidic substance and the rivastigmine free base to a mixed reaction to form a mixture having a pH value from 6.0 to 8.5 as the active ingredient; and a rivastigmine free base transdermal patch having a drug layer comprising the active ingredient. The rivastigmine free base transdermal patch has a stable transdermal transmission time equal to or longer than 48 hours and equal to or less than 168 hours. The active ingredient produced by the method and the transdermal patch having the active ingredient allow effective and smooth release of rivastigmine free base and prolongs the release time to meet the clinical application needs.

Abstract: The present invention provides a method for producing an active ingredient for a rivastigmine free base transdermal patch having preparing a rivastigmine free base; and adding an acidic substance to the rivastigmine free base and subjecting the acidic substance and the rivastigmine free base to a mixed reaction to form a mixture having a pH value from 6.0 to 8.5 as the active ingredient; and a rivastigmine free base transdermal patch having a drug layer comprising the active ingredient. The rivastigmine free base transdermal patch has a stable transdermal transmission time equal to or longer than 48 hours and equal to or less than 168 hours. The active ingredient produced by the method and the transdermal patch having the active ingredient allow effective and smooth release of rivastigmine free base and prolongs the release time to meet the clinical application needs.

Abstract: The present invention is related to a composition for enhancing topical and transdermal absorption comprising an alkali material having a pH in the range of about 9.0 to 14.0 and a water-soluble substance in an amount of at least 0.5 wt % more than an amount of the alkali material based on a total weight of the composition. The present invention is also related to a pharmaceutical composition comprising the composition, at least one therapeutically effective amount of a drug or an effective cosmetic ingredient, and a pharmaceutically acceptable carrier. The present invention is also related to a method for enhancing and delivering a drug through a body surface to minimize or eliminate the possibility of skin damage, irritation or sensitization while the above-described composition or the pharmaceutical composition is crossing patient's skin or mucosal tissue.

Abstract: The present invention is related to a composition for enhancing topical and transdermal absorption comprising an alkali material having a pH in the range of about 9.0 to 14.0 and a water-soluble substance in an amount of more than 0.5 wt % based on a total weight of the composition. The present invention is also related to a pharmaceutical composition comprising the composition, at least one therapeutically effective amount of a drug or an effective cosmetic ingredient, and a pharmaceutically acceptable carrier. The present invention is also related to a method for enhancing and delivering a drug through a body surface to minimize or eliminate the possibility of skin damage, irritation or sensitization while the above-described composition or the pharmaceutical composition is crossing patient's skin or mucosal tissue.

Abstract: A combustion powered nail gun includes a combustion sleeve moveable between a sealed position and an open position; a trigger switch having a first hook portion; a safety lever pivotally mounted in a housing and provided with a second hook biasable to be engaged with the first hook portion; and a restriction member connected to and moveable along with the combustion sleeve in a way that when the combustion sleeve is in the open position, the restriction member is stopped at the safety lever in which the second hook portion is engaged with the first hook portion so as to lock the trigger switch, and when the combustion sleeve is in the sealed position, the restriction member is spaced away from the safety lever to enable the second hook portion to be biasable away from the first hook portion so as to unlock the trigger switch.

Abstract: Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the organic base. Compositions and transdermal systems are also described.

Abstract: Methods, formulations, and drug delivery systems are provided for enhancing the flux of a transdermally administered hydrophilic drug using a basic permeation enhancer composition. The enhancer composition contains an inorganic hydroxide and a weaker, nitrogenous base, wherein the bases are selected such that a 0.1M aqueous solution of the nitrogenous base has a pH that is about 1.0 to about 6.5 lower than the pH of a 0.1M aqueous solution of the inorganic hydroxide. Additionally, the molar ratio of the nitrogenous base to the inorganic hydroxide in the enhancer composition is in the range of about 0.5n:1 to about 20n:1, where n is the number of hydroxide ions per molecule of the inorganic hydroxide.

Abstract: A combustion powered nail gun includes a combustion sleeve moveable between a sealed position and an open position; a trigger switch having a first hook portion; a safety lever pivotally mounted in a housing and provided with a second hook biasable to be engaged with the first hook portion; and a restriction member connected to and moveable along with the combustion sleeve in a way that when the combustion sleeve is in the open position, the restriction member is stopped at the safety lever in which the second hook portion is engaged with the first hook portion so as to lock the trigger switch, and when the combustion sleeve is in the sealed position, the restriction member is spaced away from the safety lever to enable the second hook portion to be biasable away from the first hook portion so as to unlock the trigger switch.

Abstract: Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.

Abstract: A method is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Topically applied formulations and drug delivery devices employing hydroxide-releasing agents as permeation enhancers are provided as well.

Abstract: Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.

Abstract: A nail-driving device has a housing, a trigger unit, a safety unit, a connecting unit and a magazine. The safety unit has first and second safety members in the housing. The connecting unit is connected pivotally to the second safety member, and has a retaining portion disposed movably between the first and second safety members. The magazine has a pusher for pushing nails therein. When the retaining portion is in a retaining position, a force is applicable to the first safety member to move the second safety member to pivot a trigger arm for a nail-driving operation when the trigger unit is actuated. When the nails thereof are exhausted, the pusher moves to a retention releasing position to pivot the connecting unit and remove the retaining portion from the retaining position to allow for relative movement of the first and second safety members to prevent the nail-driving operation.

Abstract: A method and composition for the transdermal administration of proton pump inhibitors such as substituted pyridyl methylsulfinyl benzimidazoles, and in particular, omeprazole, lansoprazole, esomeprazole, pantoprazole and raberprazole. The method and composition include the use of a hydroxide-releasing agent as a permeation enhancer to increase the flux of the protein pump inhibitor through a patient's skin or mucosal tissues and optionally also include the use of a carrier such as 1,3-butanediol, dipropylene glycol, and hexylene glycol.

Abstract: A method and related compositions, including the use of N-acyl derivatives of sarcosine, provide for the delivery of bioactive agents through tissue surfaces such as the skin. The method and composition are particularly well suited for hydrophobic active agents such as serotonin (5HT3) receptor antagonists (e.g., ondansetron), antipsychotic agents (e.g., risperidone), benzodiazepines (e.g., flumazenil), and progestins (e.g., levonorgestrel).

Abstract: The present invention provides an anti-misfit structure for a nail cartridge, which resolves the problems of a typical nail cartridge. For example, when a short collated nail is mistakenly inserted, it is likely lead to different triggering strength, and easier swinging and jamming of nail bodies against stability and safety. The swinging end of the spring of the nail cartridge is provided with a stopper. So, when the nailer head of a short collated nail is mistakenly inserted into the long nailer head dent, the stopper blocks the collated nail, thus preventing any misalignment and subsequent triggering of a nailer for higher stability and safety.

Abstract: The present invention includes transdermal delivery systems having a polymeric active agent reservoir fabricated from an admixture of polyisobutylene and an insoluble hydrophilic polymer in powdered form, which provide numerous advantages in the transdermal delivery of active agents using basic enhancer compositions. For example, the systems of the invention provide for (1) increased permeation of the active agent through the skin, (2) an improved capability of extracting the active agent and enhancer from the transdermal systems, (3) enhanced structural integrity, (4) good chemical stability, (5) reduced phase separation, and (6) decreased cold flow.

Abstract: A nail-driving device includes a housing, a trigger unit, a safety unit, a connecting unit, and a magazine. The safety unit includes first and second safety members disposed movably in the housing. The connecting unit includes a retaining portion disposed movably between the first and second safety members and in a retaining position whereat a force is applicable to the first safety member to move the second safety member to pivot a trigger arm of the trigger unit so as to allow for a nail-driving operation when the trigger unit is actuated. The magazine includes a pusher for pushing and moving nails in the magazine. The pusher is movable to a retention releasing position whereat the retaining portion of the safety unit is removed from the retaining position to thereby allow for relative movement of the first and second safety members so that a nail-driving operation is prevented.

Abstract: The present invention provides an anti-misfit structure for a nail cartridge, which resolves the problems of a typical nail cartridge. For example, when a short collated nail is mistakenly inserted, it is likely lead to different triggering strength, and easier swinging and jamming of nail bodies against stability and safety. The swinging end of the spring of the nail cartridge is provided with a stopper. So, when the nailer head of a short collated nail is mistakenly inserted into the long nailer head dent, the stopper blocks the collated nail, thus preventing any misalignment and subsequent triggering of a nailer for higher stability and safety.

Abstract: A method is provided for increasing the permeability of skin or mucosal tissue to transdermally administered nonsteroidal anti-inflammatory drugs (NSAIDs). The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the NSAID through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Formulations and drug delivery systems for co-administering a hydroxide-releasing agent with an NSAID are provided as well.

Abstract: Provided is a topical pharmaceutical composition for the treatment of inflammatory dermatoses, including acne vulgaris, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of inflammatory dermatoses plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.