Patents by Inventor Tsung-Ying Shen

Tsung-Ying Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-Mercaptopyridoxine esters
    Patent number: 4057637
    Abstract: Mercaptoalkylpyridines and various derivatives thereof have utility in the treatment of rheumatoid arthritis. The compounds useful in the method of treatment are generally prepared from known pyridine derivatives and, principally, from pyridoxine and related compounds.
    Type: Grant
    Filed: May 11, 1976
    Date of Patent: November 8, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Dennis M. Mulvey, Conrad P. Dorn
  • Acyl cyanoguanidines
    Patent number: 4057642
    Abstract: Certain novel acyl cyanoguanidines, their preparation, pharmaceutical compositions and novel methods of treating inflammation and autoimmune diseases such as rheumatoid arthritis are disclosed.
    Type: Grant
    Filed: September 30, 1975
    Date of Patent: November 8, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Howard Jones, Tsung-Ying Shen
  • Mercaptoalkylpyridine disulfides
    Patent number: 4053606
    Abstract: Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.
    Type: Grant
    Filed: July 16, 1976
    Date of Patent: October 11, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Conrad P. Dorn
  • Anti-inflammatory, analgesic and antipyretic phenylacetic acids
    Patent number: 4046905
    Abstract: The invention relates to a novel class of 4-(benzoxazol-2-yl)phenylacetic acids, alcohols, esters, amides and the non-toxic pharmaceutically acceptable salts thereof and processes for their preparation. The invention further pertains to a class of (benzoxazol-2-yl)phenylacetic acids useful as antiinflammatory agents.
    Type: Grant
    Filed: August 14, 1975
    Date of Patent: September 6, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Jorge P. Li, Conrad P. Dorn, Jr.
  • Anti-inflammatory oxazole[4,5-b]pyridines
    Patent number: 4038396
    Abstract: The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.
    Type: Grant
    Filed: May 2, 1975
    Date of Patent: July 26, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Robert L. Clark, Arsenio A. Pessolano, Bruce E. Witzel, Thomas J. Lanza
  • 3-[N'-(3-Halopropyl)-N-'-methylamino]-N,N,N-trimethyl-1-propanaminium halide and acid addition salts thereof
    Patent number: 4016209
    Abstract: Novel linear, unbranched, non-cross-linked polymers particularly poly-[{methyl-(3-trimethylammoniopropyl)imino} trimethylene dihalide] are prepared by the polymerization of the novel monomer, 3-[N'-(3-halopropyl)-N'-methylamino]-N,N,N-trimethyl-l-propanaminium halide, or an acid addition salt thereof preferably in an oxygen excluded environment, e.g., under nitrogen or argon. The polymer, especially after modification of terminal groups, is an excellent oral anticholesterolemic.
    Type: Grant
    Filed: April 23, 1975
    Date of Patent: April 5, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Arthur F. Wagner, Tsung-Ying Shen
  • 3,6-Bis(2-piperidinyl)-2,5-piperazinedione compounds
    Patent number: 4007190
    Abstract: Novel derivatives of 3,6-bis(2-piperidinyl)-2,5-piperazinedione and processes for preparing the same. The new compounds exhibit activity in inhibiting the growth of tumors in mammals and birds, and in inhibiting the growth of certain microorganisms.
    Type: Grant
    Filed: June 21, 1974
    Date of Patent: February 8, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Norman P. Jensen, Arthur F. Wagner
  • 3-Phenyl,3H 1,2,3 triazolo[4,5-b]pyridines
    Patent number: 4000286
    Abstract: 3H-1,2,3-Triazolo[4,5-b]pyridines substituted in the 3-position have utility as analgesic, anti-inflammatory and anti-pyretic agents. They are prepared by diazotization of a 3-amino-2-(substitute) aminopyridine.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: December 28, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Clark, Arsenio A. Pessolano, Tsung-Ying Shen
  • S,S'-bis(pyridylmethyl)-carbonodithioates
    Patent number: 3971797
    Abstract: S,S'-bis(pyridylmethyl)-carbonodithioates and derivatives thereof have utility in the treatment of rheumatoid arthritis. The compound useful in the method of treatment is prepared from known pyridine derivatives and, principally, from pyridoxine and related compounds.
    Type: Grant
    Filed: May 16, 1974
    Date of Patent: July 27, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Dennis M. Mulvey, Conrad P. Dorn
  • Cathepsin in D inhibitors
    Patent number: 3971736
    Abstract: Hexa- and heptapeptides of formula W-[X-Pro-Phe-Phe-Y-Z].sub.n H prepared by standard synthetic peptide techniques are anti-inflammatory, anti-rheumatoid arthritic and anti-ulcer agents.
    Type: Grant
    Filed: January 21, 1975
    Date of Patent: July 27, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Arthur F. Wagner, Frederick W. Holly, Tsau-Yen Lin, Tsung-Ying Shen, Ralph F. Hirschmann
  • Substituted indenyl acetic acids
    Patent number: 3956363
    Abstract: New substituted indenyl acetic acids and nontoxic pharmaceutically acceptable amides, esters and salts derived therefrom. The substituted indenyl acetic acids disclosed herein have anit-inflammatory, anti-pyretic and analgesic activity.
    Type: Grant
    Filed: August 23, 1974
    Date of Patent: May 11, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Richard B. Greenwald, Howard Jones, Bruce O. Linn, Bruce E. Witzel
  • Indenylacetic acid compounds
    Patent number: 3954852
    Abstract: 4, 5, 6 or 7 Aryl substituted indenyl acetic acids and pharmaceutically acceptable salts, amides and esters thereof. The 4, 5, 6 or 7 aryl substituted indenyl acetic acids have anti-inflammatory, anti-pyretic and analgesic activity. The invention also includes methods for the preparation of these compounds, pharmaceutical compositions and methods of treating inflammation by administering these particular compounds to patients.
    Type: Grant
    Filed: October 19, 1973
    Date of Patent: May 4, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones
  • Thiadiazoles as anti-inflammatory agents
    Patent number: 3949082
    Abstract: The invention relates to a method of treating inflammation employing 1,3,4-thiadiazole compounds and to pharmaceutical compositions thereof.
    Type: Grant
    Filed: July 24, 1974
    Date of Patent: April 6, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Tsung-Ying Shen
  • Phenylacetic acid compounds in treating abnormal platelet aggregation
    Patent number: 3947582
    Abstract: Pharmaceutical Compositions based on 4-(Benzoxazol-2-yl)phenylacetic acids, alcohols, esters, amides and their non-toxic pharmaceutically acceptable salts and method of treating abnormal platelet aggregation.
    Type: Grant
    Filed: February 10, 1975
    Date of Patent: March 30, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Jorge P. Li, Conrad P. Dorn, Jr.
  • 3-Indenyl-.gamma.-(ketobutyric)-acid compounds
    Patent number: 3932498
    Abstract: New substituted indene acids and non-toxic pharmaceutically acceptable amides, esters and salts derived therefrom. The substituted indene acids disclosed herein have anti-inflammatory, anti-pyretic and analgesic activity. Also included herein are methods of preparing said indene acid compounds, pharmaceutical compositions having said indene acid compounds as an active ingredient and methods of treating inflammation by administering these particular compositions to patients.
    Type: Grant
    Filed: February 23, 1973
    Date of Patent: January 13, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Michael W. Fordice