Patents by Inventor Tsutomu Agatsuma
Tsutomu Agatsuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9260459Abstract: A 4,6-hexadecadiene-2,4-dicarboxylic acid derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, each of which has an anti-tumor activity, and the like, are provided. [wherein, R1 represents hydroxy, —OR3 (wherein R3 represents optionally substituted lower alkyl or an optionally substituted aliphatic heterocyclic group), or —NR4R5 (wherein R4 and R5 may be the same or different, and each represents a hydrogen atom or optionally substituted lower alkyl) and R2 represents hydroxy or —OR6 (wherein R6 represents optionally substituted lower alkyl or optionally substituted aralkyl)].Type: GrantFiled: June 25, 2013Date of Patent: February 16, 2016Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Shimpei Yamaguchi, Yumiko Uochi, Tsutomu Agatsuma, Susumu Iwamoto, Hideyuki Onodera
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Publication number: 20150183809Abstract: A 4,6-hexadecadiene-2,4-dicarboxylic acid derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, each of which has an anti-tumor activity, and the like, are provided.Type: ApplicationFiled: June 25, 2013Publication date: July 2, 2015Inventors: Shimpei Yamaguchi, Yumiko Uochi, Tsutomu Agatsuma, Susumu Iwamoto, Hideyuki Onodera
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Publication number: 20150119585Abstract: The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xa and Xb are the same or different, and represent a bond or the like; R1, R2, R3, R4, R7 and R8 are the same or different, and represent a hydrogen atom or the like; R5 and R6 are the same or different, and represent a hydrogen atom or the like; R9 represents a hydrogen atom or the like; R10 and R11 together represent a bond or the like; and R12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: December 30, 2014Publication date: April 30, 2015Applicant: KYOWA HAKKO KIRIN CO., LTDInventors: Kenji UCHIDA, Tsutomu AGATSUMA, Kazuhiro HIBINO, Setsuya SASHO, Kyoichiro IIDA, Hideyuki ONODERA
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Patent number: 8952003Abstract: The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xa and Xb are the same or different, and represent a bond or the like; R1, R2, R3, R4, R7 and R8 are the same or different, and represent a hydrogen atom or the like; R5 and R6 are the same or different, and represent a hydrogen atom or the like; R9 represents a hydrogen atom or the like; R10 and R11 together represent a bond or the like; and R12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 22, 2010Date of Patent: February 10, 2015Assignee: Kyowa Hakko Kirin Co., LtdInventors: Kenji Uchida, Tsutomu Agatsuma, Kazuhiro Hibino, Setsuya Sasho, Kyoichiro Iida, Hideyuki Onodera
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Publication number: 20120172348Abstract: The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xa and Xb are the same or different, and represent a bond or the like; R1, R2, R3, R4, R7 and R8 are the same or different, and represent a hydrogen atom or the like; R5 and R6 are the same or different, and represent a hydrogen atom or the like; R9 represents a hydrogen atom or the like; R10 and R11 together represent a bond or the like; and R12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: July 22, 2010Publication date: July 5, 2012Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Kenji Uchida, Tsutomu Agatsuma, Kazuhiro Hibino, Setsuya Sasho, Kyoichiro Iida, Hideyuki Onodera
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Publication number: 20110020931Abstract: A proliferation promoting agent for neural stem cells, which comprises a compound produced by Penicillium sp. CND1007 (FERM BP-10917) or a pharmaceutically acceptable salt thereof, as an active ingredient; a novel compound produced by Penicillium sp. CND 1007 or a pharmaceutically acceptable salt thereof; a method for producing neural stem cells, which comprises culturing a neural stem cells to proliferate the neural stem cells in a presence of the compound produced by Penicillium sp. CND 1007 or a pharmaceutically acceptable salt thereof, and harvesting the neural stem cells from the culture; and the like are provided.Type: ApplicationFiled: January 29, 2009Publication date: January 27, 2011Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Hideyuki Onodera, Michio Ichimura, Kouji Baba, Tsutomu Agatsuma, Setsuya Sasho, Makoto Suzuki, Susumu Iwamoto, Shingo Kakita
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Patent number: 6953785Abstract: Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I): {wherein R1 and R2 are the same or different and represent a hydrogen atom, a lower alkyl group or, etc.; R3 represents a hydrogen atom etc.; R4 represents a hydrogen atom etc.; R5 represents a hydrogen atom etc.; R6 represents a cyano group, an amino group, COR53 (wherein R53 represents a substituted lower alkyl group etc.), a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, etc}, or pharmaceutically acceptable salts thereof.Type: GrantFiled: April 24, 2001Date of Patent: October 11, 2005Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yoji Ino, Nobuyoshi Amishiro, Mayumi Miyata, Tsutomu Agatsuma, Kozue Muramatsu, Takeshi Takahashi, Shiro Akinaga, Chikara Murakata
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Publication number: 20050069999Abstract: The present invention provides SH3 domain binding inhibitors comprising, as an active ingredient, a non-peptide compound exhibiting SH3 domain binding inhibitory activity, a low molecular weight compound with molecular weight less than 750 which exhibit SH3 domain binding inhibitory activity, in particular, a compound represented by the general formula (I) or (II) described above, a cytochalsin, etc., or pharmaceutically acceptable salts thereof. The present invention also provides compounds represented by the general formula (Va), (Vb) or (VI) described above or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: April 19, 2002Publication date: March 31, 2005Inventors: Sreenath Sharma, Noriko Matsushita, Katsuhiko Ando, Chitose Yoshida, Hirofumi Nakano, Tsutomu Agatsuma, Yutaka Kanda
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Patent number: 6869971Abstract: UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I): wherein R1 represents hydrogen, lower alkyl, etc.; R2 represents hydrogen, or is combined with R3 to represent a bond, etc., or is combined with R4 to represent —O(C?O)—, etc.; R3 represents hydrogen, etc., or is combined with R2 to represent a bond, etc.; R4 represents hydrogen, etc., or is combined with R2 to represent —(C?O)O—, etc.; R5 represents hydrogen or is combined with R6 to represent a bond; R6 represents hydrogen, etc., or is combined with R5 to represent a bond; R7 represents hydrogen or is combined with R8 to represent ?O; R8 represents hydroxy or is combined with R7 to represent ?O; ---- represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.Type: GrantFiled: October 19, 2000Date of Patent: March 22, 2005Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tsutomu Akama, Akira Asai, Tsutomu Agatsuma, Shinji Nara, Yoshinori Yamashita, Tamio Mizukami, Shun-ichi Ikeda, Yutaka Saitoh, Yutaka Kanda
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Publication number: 20030216362Abstract: Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I): 1Type: ApplicationFiled: October 24, 2002Publication date: November 20, 2003Inventors: Yoji Ino, Nobuyoshi Amishiro, Mayumi Miyata, Tsutomu Agatsuma, Kozue Muramatsu, Takeshi Takahashi
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Patent number: 5977165Abstract: The present invention relates to radicicol derivatives represented by the following formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert-butyldimethylsilyl; (1) when X represents halogen, Y represents an oxygen atom or R.sup.4 --O--N (wherein R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl); and R.sup.3 represents hydrogen, alkanoyl, alkenoyl or the like; and (2) when X and R.sup.3 are combined with each other to represent a single bond; Y represents R.sup.4B --O--N (wherein R.sup.4B has the same meaning as R.sup.4). The radicicol derivatives of the present invention demonstrate tyrosine kinase inhibition activity and pharmacological activities such as antitumor, antimicrobial or immunosuppression effects.Type: GrantFiled: October 27, 1997Date of Patent: November 2, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tsutomu Agatsuma, Yutaka Saitoh, Yoshinori Yamashita, Tamio Mizukami, Shiro Akinaga, Katsushige Gomi, Kazuhito Akasaka, Isami Takahashi
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Patent number: 5874592Abstract: The present invention relates to a novel compound EI-2128-1 having IL-1 production inhibitory activity which is represented by formula (I): ##STR1##Type: GrantFiled: November 12, 1997Date of Patent: February 23, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takeo Tanaka, Fumito Koizumi, Tsutomu Agatsuma, Hidemasa Kondo, Yutaka Saitoh, Katsuhiko Ando, Yuzuru Matsuda
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Patent number: 5804599Abstract: Provided is an Interleukin-1 production inhibiting compound represented by formula (I) ##STR1## wherein R denotes 4-methyl-1-pentenyl, 5-methyl-1,3-heptadienyl or 1-methylpentanyl.Type: GrantFiled: September 27, 1995Date of Patent: September 8, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takeo Tanaka, Eiji Tsukuda, Keiko Ochiai, Katsuhiko Ando, Hidemasa Kondo, Youichi Uosaki, Yutaka Saitoh, Yuzuru Matsuda, Fumito Koizumi, Tsutomu Agatsuma
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Patent number: 5798379Abstract: UCS1025 compounds represented by the following formula (I): ##STR1## wherein R represents hydrogen or hydroxyl group, or tautomers or pharmacologically acceptable salts thereof.Type: GrantFiled: December 18, 1997Date of Patent: August 25, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tamio Mizukami, Harumi Ogawa, Ryuichiro Nakai, Akira Asai, Yoshinori Yamashita, Katsuhiko Ando, Tsutomu Agatsuma, Shiro Akinaga, Kozo Ouchi, Hideki Kawasaki
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Patent number: 5665703Abstract: A GE3 compound of the formula (I) having antibacterial and antitumor properties: ##STR1##Type: GrantFiled: December 5, 1995Date of Patent: September 9, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tamio Mizukami, Yasushi Sakai, Tetsuo Yoshida, Tsutomu Agatsuma, Keiko Ochiai, Shiro Akinaga
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Patent number: 5510501Abstract: The present invention relates to Saintopin derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 is hydrogen and R.sup.2 is SO.sub.2 OH (UCE 1022), or R.sup.1 is acetyl and R.sup.2 is H (Saintopin E), which are useful as antibacterial and anti-tumor agents.Type: GrantFiled: July 21, 1994Date of Patent: April 23, 1996Assignee: Kyowa Hakko Kogyo, Co. Ltd.Inventors: Hirofumi Nakano, Noboru Fujii, Yoshinori Yamashita, Yutaka Saitoh, Tsutomu Agatsuma, Katsuhiko Ando, Yasushi Nishiie, Katsunori Kita, Naoki Morishima, Katsushige Gomi