Patents by Inventor Tsutomu Agatsuma

Tsutomu Agatsuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9260459
    Abstract: A 4,6-hexadecadiene-2,4-dicarboxylic acid derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, each of which has an anti-tumor activity, and the like, are provided. [wherein, R1 represents hydroxy, —OR3 (wherein R3 represents optionally substituted lower alkyl or an optionally substituted aliphatic heterocyclic group), or —NR4R5 (wherein R4 and R5 may be the same or different, and each represents a hydrogen atom or optionally substituted lower alkyl) and R2 represents hydroxy or —OR6 (wherein R6 represents optionally substituted lower alkyl or optionally substituted aralkyl)].
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: February 16, 2016
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Shimpei Yamaguchi, Yumiko Uochi, Tsutomu Agatsuma, Susumu Iwamoto, Hideyuki Onodera
  • Publication number: 20150183809
    Abstract: A 4,6-hexadecadiene-2,4-dicarboxylic acid derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, each of which has an anti-tumor activity, and the like, are provided.
    Type: Application
    Filed: June 25, 2013
    Publication date: July 2, 2015
    Inventors: Shimpei Yamaguchi, Yumiko Uochi, Tsutomu Agatsuma, Susumu Iwamoto, Hideyuki Onodera
  • Publication number: 20150119585
    Abstract: The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xa and Xb are the same or different, and represent a bond or the like; R1, R2, R3, R4, R7 and R8 are the same or different, and represent a hydrogen atom or the like; R5 and R6 are the same or different, and represent a hydrogen atom or the like; R9 represents a hydrogen atom or the like; R10 and R11 together represent a bond or the like; and R12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 30, 2014
    Publication date: April 30, 2015
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Kenji UCHIDA, Tsutomu AGATSUMA, Kazuhiro HIBINO, Setsuya SASHO, Kyoichiro IIDA, Hideyuki ONODERA
  • Patent number: 8952003
    Abstract: The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xa and Xb are the same or different, and represent a bond or the like; R1, R2, R3, R4, R7 and R8 are the same or different, and represent a hydrogen atom or the like; R5 and R6 are the same or different, and represent a hydrogen atom or the like; R9 represents a hydrogen atom or the like; R10 and R11 together represent a bond or the like; and R12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: February 10, 2015
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Kenji Uchida, Tsutomu Agatsuma, Kazuhiro Hibino, Setsuya Sasho, Kyoichiro Iida, Hideyuki Onodera
  • Publication number: 20120172348
    Abstract: The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xa and Xb are the same or different, and represent a bond or the like; R1, R2, R3, R4, R7 and R8 are the same or different, and represent a hydrogen atom or the like; R5 and R6 are the same or different, and represent a hydrogen atom or the like; R9 represents a hydrogen atom or the like; R10 and R11 together represent a bond or the like; and R12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 22, 2010
    Publication date: July 5, 2012
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Kenji Uchida, Tsutomu Agatsuma, Kazuhiro Hibino, Setsuya Sasho, Kyoichiro Iida, Hideyuki Onodera
  • Publication number: 20110020931
    Abstract: A proliferation promoting agent for neural stem cells, which comprises a compound produced by Penicillium sp. CND1007 (FERM BP-10917) or a pharmaceutically acceptable salt thereof, as an active ingredient; a novel compound produced by Penicillium sp. CND 1007 or a pharmaceutically acceptable salt thereof; a method for producing neural stem cells, which comprises culturing a neural stem cells to proliferate the neural stem cells in a presence of the compound produced by Penicillium sp. CND 1007 or a pharmaceutically acceptable salt thereof, and harvesting the neural stem cells from the culture; and the like are provided.
    Type: Application
    Filed: January 29, 2009
    Publication date: January 27, 2011
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Hideyuki Onodera, Michio Ichimura, Kouji Baba, Tsutomu Agatsuma, Setsuya Sasho, Makoto Suzuki, Susumu Iwamoto, Shingo Kakita
  • Patent number: 6953785
    Abstract: Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I): {wherein R1 and R2 are the same or different and represent a hydrogen atom, a lower alkyl group or, etc.; R3 represents a hydrogen atom etc.; R4 represents a hydrogen atom etc.; R5 represents a hydrogen atom etc.; R6 represents a cyano group, an amino group, COR53 (wherein R53 represents a substituted lower alkyl group etc.), a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, etc}, or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: October 11, 2005
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yoji Ino, Nobuyoshi Amishiro, Mayumi Miyata, Tsutomu Agatsuma, Kozue Muramatsu, Takeshi Takahashi, Shiro Akinaga, Chikara Murakata
  • Publication number: 20050069999
    Abstract: The present invention provides SH3 domain binding inhibitors comprising, as an active ingredient, a non-peptide compound exhibiting SH3 domain binding inhibitory activity, a low molecular weight compound with molecular weight less than 750 which exhibit SH3 domain binding inhibitory activity, in particular, a compound represented by the general formula (I) or (II) described above, a cytochalsin, etc., or pharmaceutically acceptable salts thereof. The present invention also provides compounds represented by the general formula (Va), (Vb) or (VI) described above or pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: April 19, 2002
    Publication date: March 31, 2005
    Inventors: Sreenath Sharma, Noriko Matsushita, Katsuhiko Ando, Chitose Yoshida, Hirofumi Nakano, Tsutomu Agatsuma, Yutaka Kanda
  • Patent number: 6869971
    Abstract: UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I): wherein R1 represents hydrogen, lower alkyl, etc.; R2 represents hydrogen, or is combined with R3 to represent a bond, etc., or is combined with R4 to represent —O(C?O)—, etc.; R3 represents hydrogen, etc., or is combined with R2 to represent a bond, etc.; R4 represents hydrogen, etc., or is combined with R2 to represent —(C?O)O—, etc.; R5 represents hydrogen or is combined with R6 to represent a bond; R6 represents hydrogen, etc., or is combined with R5 to represent a bond; R7 represents hydrogen or is combined with R8 to represent ?O; R8 represents hydroxy or is combined with R7 to represent ?O; ---- represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: March 22, 2005
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tsutomu Akama, Akira Asai, Tsutomu Agatsuma, Shinji Nara, Yoshinori Yamashita, Tamio Mizukami, Shun-ichi Ikeda, Yutaka Saitoh, Yutaka Kanda
  • Publication number: 20030216362
    Abstract: Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I): 1
    Type: Application
    Filed: October 24, 2002
    Publication date: November 20, 2003
    Inventors: Yoji Ino, Nobuyoshi Amishiro, Mayumi Miyata, Tsutomu Agatsuma, Kozue Muramatsu, Takeshi Takahashi
  • Patent number: 5977165
    Abstract: The present invention relates to radicicol derivatives represented by the following formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert-butyldimethylsilyl; (1) when X represents halogen, Y represents an oxygen atom or R.sup.4 --O--N (wherein R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl); and R.sup.3 represents hydrogen, alkanoyl, alkenoyl or the like; and (2) when X and R.sup.3 are combined with each other to represent a single bond; Y represents R.sup.4B --O--N (wherein R.sup.4B has the same meaning as R.sup.4). The radicicol derivatives of the present invention demonstrate tyrosine kinase inhibition activity and pharmacological activities such as antitumor, antimicrobial or immunosuppression effects.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: November 2, 1999
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tsutomu Agatsuma, Yutaka Saitoh, Yoshinori Yamashita, Tamio Mizukami, Shiro Akinaga, Katsushige Gomi, Kazuhito Akasaka, Isami Takahashi
  • Patent number: 5874592
    Abstract: The present invention relates to a novel compound EI-2128-1 having IL-1 production inhibitory activity which is represented by formula (I): ##STR1##
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: February 23, 1999
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Takeo Tanaka, Fumito Koizumi, Tsutomu Agatsuma, Hidemasa Kondo, Yutaka Saitoh, Katsuhiko Ando, Yuzuru Matsuda
  • Patent number: 5804599
    Abstract: Provided is an Interleukin-1 production inhibiting compound represented by formula (I) ##STR1## wherein R denotes 4-methyl-1-pentenyl, 5-methyl-1,3-heptadienyl or 1-methylpentanyl.
    Type: Grant
    Filed: September 27, 1995
    Date of Patent: September 8, 1998
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Takeo Tanaka, Eiji Tsukuda, Keiko Ochiai, Katsuhiko Ando, Hidemasa Kondo, Youichi Uosaki, Yutaka Saitoh, Yuzuru Matsuda, Fumito Koizumi, Tsutomu Agatsuma
  • Patent number: 5798379
    Abstract: UCS1025 compounds represented by the following formula (I): ##STR1## wherein R represents hydrogen or hydroxyl group, or tautomers or pharmacologically acceptable salts thereof.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: August 25, 1998
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tamio Mizukami, Harumi Ogawa, Ryuichiro Nakai, Akira Asai, Yoshinori Yamashita, Katsuhiko Ando, Tsutomu Agatsuma, Shiro Akinaga, Kozo Ouchi, Hideki Kawasaki
  • Patent number: 5665703
    Abstract: A GE3 compound of the formula (I) having antibacterial and antitumor properties: ##STR1##
    Type: Grant
    Filed: December 5, 1995
    Date of Patent: September 9, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tamio Mizukami, Yasushi Sakai, Tetsuo Yoshida, Tsutomu Agatsuma, Keiko Ochiai, Shiro Akinaga
  • Patent number: 5510501
    Abstract: The present invention relates to Saintopin derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 is hydrogen and R.sup.2 is SO.sub.2 OH (UCE 1022), or R.sup.1 is acetyl and R.sup.2 is H (Saintopin E), which are useful as antibacterial and anti-tumor agents.
    Type: Grant
    Filed: July 21, 1994
    Date of Patent: April 23, 1996
    Assignee: Kyowa Hakko Kogyo, Co. Ltd.
    Inventors: Hirofumi Nakano, Noboru Fujii, Yoshinori Yamashita, Yutaka Saitoh, Tsutomu Agatsuma, Katsuhiko Ando, Yasushi Nishiie, Katsunori Kita, Naoki Morishima, Katsushige Gomi