Patents by Inventor Tsutomu Hoshino
Tsutomu Hoshino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11414655Abstract: An object of the present invention is to provide a method for preparing ambrein, which can easily and efficiently obtain the ambrein. The object can be solved by a mutated tetraprenyl-?-curcumene cyclase wherein (1) a 4th amino acid residue of a DXDD motif, aspartic acid, is substituted with an amino acid other than aspartic acid, and (2) an amino acid adjacent to the N-terminus of a (A/S/G)RX(H/N)XXP motif is substituted with an amino acid other than tyrosine, or a 4th amino acid of the GXGX(G/A/P) motif is substituted with an amino acid other than leucine.Type: GrantFiled: August 31, 2018Date of Patent: August 16, 2022Assignees: Niigata University, Adeka CorporationInventors: Tsutomu Sato, Tsutomu Hoshino, Toshihiko Takehana, Seiji Koike, Koichi Shigeno
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Patent number: 11399730Abstract: Devices and methods are provided for analyzing images from a magnetic resonance (MR) system. The device includes at least one hardware processor coupled with a storage system accessible to the at least one hardware processor. The device further includes a display in communication with the at least one hardware processor. The device receives a plurality of non-contrast MR images in a region of interest (ROI). The device obtains blood flow signals from the plurality of non-contrast MR images. The device identifies an abnormal segment by analyzing the blood flow signals. The device displays the non-contrast MR images by a highlighted segment in at least one of the non-contrast MR images to indicate the abnormal segment on the display.Type: GrantFiled: March 23, 2016Date of Patent: August 2, 2022Assignee: CANON MEDICAL SYSTEMS CORPORATIONInventors: Mitsue Miyazaki, Tsutomu Hoshino, Xiangzhi Zhou
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Patent number: 10980492Abstract: A magnetic resonance imaging (MRI) apparatus according to an exemplary embodiment includes a sequence controller and a data processor. The sequence controller executes a pulse sequence using a combination of multiple types of labeling methods to acquire magnetic resonance signals. The data processor generates multiple types of labeled images based on the magnetic resonance signals.Type: GrantFiled: March 11, 2014Date of Patent: April 20, 2021Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATIONInventors: Tsutomu Hoshino, Mitsue Miyazaki
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Patent number: 10901060Abstract: A magnetic resonance imaging apparatus according to an embodiment includes sequence control circuitry and processing circuitry. The sequence control circuitry performs first data acquisition in a full k-space and performs a plurality of second data acquisition in partial k-spaces, each of the partial k-spaces being smaller than the entirety of the full k-space. The processing circuitry generates an image, based on data acquired from the first data acquisition and a plurality of pieces of data acquired from the plurality of second data acquisition.Type: GrantFiled: March 1, 2016Date of Patent: January 26, 2021Assignee: CANON MEDICAL SYSTEMS CORPORATIONInventors: Mitsue Miyazaki, Satoshi Sugiura, Tsutomu Hoshino, Xiangzhi Zhou
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Publication number: 20200354754Abstract: An object of the present invention is to provide a method for preparing ambrein, which can easily and efficiently obtain the ambrein. The object can be solved by a mutated tetraprenyl-?-curcumene cyclase wherein (1) a 4th amino acid residue of a DXDD motif, aspartic acid, is substituted with an amino acid other than aspartic acid, and (2) an amino acid adjacent to the N-terminus of a (A/S/G)RX(H/N)XXP motif is substituted with an amino acid other than tyrosine, or a 4th amino acid of the GXGX(G/A/P) motif is substituted with an amino acid other than leucine.Type: ApplicationFiled: August 31, 2018Publication date: November 12, 2020Applicants: Niigata University, Adeka CorporationInventors: Tsutomu Sato, Tsutomu Hoshino, Toshihiko Takehana, Seiji Koike, Koichi Shigeno
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Patent number: 10368777Abstract: Black blood time to inversion (BBTI) tag-on and tag-off images acquired by magnetic resonance imaging (MRI) are analyzed to produce difference magnitude 3D images as a function of time (BBTI values) representing blood perfusion in a region of interest (ROI). Perfusion data of the ROI having values which are different for normal and abnormal myocardial tissues are displayed for plural slices of a 3D image and for plural BBTI values in a single display panel.Type: GrantFiled: September 14, 2012Date of Patent: August 6, 2019Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATIONInventors: Xiangzhi Zhou, Mitsue Miyazaki, Tsutomu Hoshino
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Patent number: 9902979Abstract: Provided is a method for producing ambrein, comprising reacting tetraprenyl-?-curcumene cyclase with 3-deoxyachilleol A to obtain ambrein.Type: GrantFiled: August 12, 2014Date of Patent: February 27, 2018Assignee: Niigata UniversityInventors: Tsutomu Sato, Daijiro Ueda, Tsutomu Hoshino
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Publication number: 20170273577Abstract: Devices and methods are provided for analyzing images from a magnetic resonance (MR) system. The device includes at least one hardware processor coupled with a storage system accessible to the at least one hardware processor. The device further includes a display in communication with the at least one hardware processor. The device receives a plurality of non-contrast MR images in a region of interest (ROI). The device obtains blood flow signals from the plurality of non-contrast MR images. The device identifies an abnormal segment by analyzing the blood flow signals. The device displays the non-contrast MR images by a highlighted segment in at least one of the non-contrast MR images to indicate the abnormal segment on the display.Type: ApplicationFiled: March 23, 2016Publication date: September 28, 2017Inventors: Mitsue Miyazaki, Tsutomu Hoshino, Xiangzhi Zhou
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Publication number: 20170254869Abstract: A magnetic resonance imaging apparatus according to an embodiment includes sequence control circuitry and processing circuitry. The sequence control circuitry performs first data acquisition in a full k-space and performs a plurality of second data acquisition in partial k-spaces, each of the partial k-spaces being smaller than the entirety of the full k-space. The processing circuitry generates an image, based on data acquired from the first data acquisition and a plurality of pieces of data acquired from the plurality of second data acquisition.Type: ApplicationFiled: March 1, 2016Publication date: September 7, 2017Applicant: TOSHIBA MEDICAL SYSTEMS CORPORATIONInventors: Mitsue MIYAZAKI, Satoshi SUGIURA, Tsutomu HOSHINO, Xiangzhi ZHOU
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Patent number: 9585575Abstract: Elicited MRI signals are processed into MR image data in conjunction (a) with use of an initial spatially-selective RF tag pulse (tag-on) and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (TI) intervals without using an injected contrast agent. Acquired image data sets are subtracted for each TI interval to produce difference values as a function of time representing blood perfusion for the ROI that differentiates between normal, ischemic and infarct tissues.Type: GrantFiled: April 17, 2015Date of Patent: March 7, 2017Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATIONInventors: Mitsue Miyazaki, Xiangzhi Zhou, Tsutomu Hoshino
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Patent number: 9545206Abstract: Elicited MRI signals are processed into MR image data in conjunction (a) with use of an initial spatially-selective RF tag pulse (tag-on) and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (TI) intervals without using an injected contrast agent. Acquired image data sets are subtracted for each TI interval to produce difference values as a function of time representing blood perfusion for the ROI that differentiates between normal, ischemic and infarct tissues.Type: GrantFiled: August 16, 2012Date of Patent: January 17, 2017Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATIONInventors: Mitsue Miyazaki, Xiangzhi Zhou, Tsutomu Hoshino
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Publication number: 20160304911Abstract: Provided is a method for producing ambrein, comprising reacting tetraprenyl-?-curcumene cyclase with 3-deoxyachilleol A to obtain ambrein.Type: ApplicationFiled: August 12, 2014Publication date: October 20, 2016Applicant: Niigata UniversityInventors: Tsutomu Sato, Daijiro Ueda, Tsutomu Hoshino
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Patent number: 9213075Abstract: A magnetic resonance imaging apparatus includes: a sequence controlling unit that, by controlling an execution of a pulse sequence, acquires magnetic resonance (MR) signals corresponding to a plurality of channels in the pulse sequence executed as a series, the MR signals being configured to be arranged into a first region of a k-space at first intervals and into a second region larger than the first region at second intervals larger than the first intervals; an arranging unit that arranges the MR signals corresponding to the channels into the k-space as k-space data; and an image generating unit that generates first-interval k-space data corresponding to the channels based on the second-interval k-space data acquired by executing the pulse sequence and generates a magnetic resonance image based on the generated first-interval k-space data, the first-interval k-space data acquired by executing the pulse sequence, and sensitivity distributions corresponding to the channels.Type: GrantFiled: November 15, 2012Date of Patent: December 15, 2015Assignees: KABUSHIKI KAISHA TOSHIBA, TOSHIBA MEDICAL SYSTEMS CORPORATIONInventors: Mitsue Miyazaki, Hidenori Takeshima, Tsutomu Hoshino, Satoshi Sugiura
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Publication number: 20150216429Abstract: Elicited MRI signals are processed into MR image data in conjunction (a) with use of an initial spatially-selective RF tag pulse (tag-on) and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (TI) intervals without using an injected contrast agent. Acquired image data sets are subtracted for each TI interval to produce difference values as a function of time representing blood perfusion for the ROI that differentiates between normal, ischemic and infarct tissues.Type: ApplicationFiled: April 17, 2015Publication date: August 6, 2015Inventors: MITSUE MIYAZAKI, Xiangzhi Zhou, Tsutomu Hoshino
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Patent number: 8855743Abstract: A magnetic resonance imaging (MRI) system acquires MRI data within one patient breath-hold sufficient to generate (a) at least one tag-off first type non-contrast cardiac perfusion image using a data acquisition sub-sequence including a non-selective IR (inversion recovery) pulse and (b) at least one tag-on second type non-contrast cardiac perfusion image using a data acquisition sub-sequence including a non-selective IR pulse and a spatially selective IR pulse. A set of registered tag-on and tag-off images are differentially combined to produce an accurate cardiac perfusion image.Type: GrantFiled: May 11, 2012Date of Patent: October 7, 2014Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems CorporationInventors: Tsutomu Hoshino, Mitsue Miyazaki
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Publication number: 20140194730Abstract: A magnetic resonance imaging (MRI) apparatus according to an exemplary embodiment includes a sequence controller and a data processor. The sequence controller executes a pulse sequence using a combination of multiple types of labeling methods to acquire magnetic resonance signals. The data processor generates multiple types of labeled images based on the magnetic resonance signals.Type: ApplicationFiled: March 11, 2014Publication date: July 10, 2014Applicants: TOSHIBA MEDICAL SYSTEMS CORPORATION, KABUSHIKI KAISHA TOSHIBAInventors: Tsutomu HOSHINO, Mitsue MIYAZAKI
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Patent number: 8749993Abstract: According to one embodiment, an electronic device of the embodiment includes a pair of racks, a box-shaped main body having a front face, a first side face which intersects with the front face, and a second side face which is opposed to the first side face, a first fixing portion which is fixed to the first side face and also to one of the racks, a second fixing portion which is fixed to the second side face and also to the other one of the racks, and a module which is mounted in the first fixing portion.Type: GrantFiled: December 16, 2011Date of Patent: June 10, 2014Assignee: Kabushiki Kaisha ToshibaInventor: Tsutomu Hoshino
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Publication number: 20140081125Abstract: Black blood time to inversion (BBTI) tag-on and tag-off images acquired by magnetic resonance imaging (MRI) are analyzed to produce difference magnitude 3D images as a function of time (BBTI values) representing blood perfusion in a region of interest (ROI). Perfusion data of the ROI having values which are different for normal and abnormal myocardial tissues are displayed for plural slices of a 3D image and for plural BBTI values in a single display panel.Type: ApplicationFiled: September 14, 2012Publication date: March 20, 2014Applicants: TOSHIBA MEDICAL SYSTEMS CORPORATION, KABUSHIKI KAISHA TOSHIBAInventors: Xiangzhi ZHOU, Mitsue MIYAZAKI, Tsutomu HOSHINO
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Publication number: 20140050379Abstract: Elicited MRI signals are processed into MR image data in conjunction (a) with use of an initial spatially-selective RF tag pulse (tag-on) and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (TI) intervals without using an injected contrast agent. Acquired image data sets are subtracted for each TI interval to produce difference values as a function of time representing blood perfusion for the ROI that differentiates between normal, ischemic and infarct tissues.Type: ApplicationFiled: August 16, 2012Publication date: February 20, 2014Applicants: TOSHIBA MEDICAL SYSTEMS CORPORATION, KABUSHIKI KAISHA TOSHIBAInventors: MITSUE MIYAZAKI, Xiangzhi Zhou, Tsutomu Hoshino
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Publication number: 20130303885Abstract: A magnetic resonance imaging (MRI) system acquires MRI data within one patient breath-hold sufficient to generate (a) at least one tag-off first type non-contrast cardiac perfusion image using a data acquisition sub-sequence including a non-selective IR (inversion recovery) pulse and (b) at least one tag-on second type non-contrast cardiac perfusion image using a data acquisition sub-sequence including a non-selective IR pulse and a spatially selective IR pulse. A set of registered tag-on and tag-off images are differentially combined to produce an accurate cardiac perfusion image.Type: ApplicationFiled: May 11, 2012Publication date: November 14, 2013Applicants: Toshiba Medical Systems Corporation, Kabushiki Kaisha ToshibaInventors: Tsutomu Hoshino, Mitsue Miyazaki