Patents by Inventor Tsutomu Imagawa
Tsutomu Imagawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9926274Abstract: The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid. (wherein A represents an organic group, R represents a hydrogen atom, or an organic group, L represents a halogen atom and the like, and n represents an integer of 2 to 20).Type: GrantFiled: July 11, 2014Date of Patent: March 27, 2018Assignee: Nippon Soda Co., Ltd.Inventors: Yasushi Shibata, Tsutomu Imagawa
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Publication number: 20150141653Abstract: The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid.Type: ApplicationFiled: January 30, 2015Publication date: May 21, 2015Inventors: Yasushi SHIBATA, Tsutomu IMAGAWA
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Patent number: 9000156Abstract: The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid.Type: GrantFiled: April 24, 2007Date of Patent: April 7, 2015Assignee: Nippon Soda Co., Ltd.Inventors: Yasushi Shibata, Tsutomu Imagawa
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Publication number: 20140323724Abstract: The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid.Type: ApplicationFiled: July 11, 2014Publication date: October 30, 2014Inventors: Yasushi SHIBATA, Tsutomu IMAGAWA
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Patent number: 8461340Abstract: There are provided, according to the present invention, a method for producing a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative, the method characterized in that a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative or a mixture of the trans- and cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivatives is isomerized in the presence of an aluminum compound represented by a formula Al(OR1)3 (wherein R1 represents a hydrocarbon group in which a carbon atom having an oxygen atom bonded thereto is a secondary carbon atom). In the process, a ketone compound may be further added, in addition to the aluminum compound.Type: GrantFiled: August 27, 2008Date of Patent: June 11, 2013Assignee: Nippon Soda Co., Ltd.Inventors: Hiroshi Hakuta, Tsutomu Imagawa, Hirohito Oooka, Shinya Fukuhara
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Patent number: 8173802Abstract: Provided is a method for producing a piperidin-4-one derivative useful as an intermediate for agricultural chemicals or pharmaceutical products. A piperidin-4-one derivative represented by formula (III-a) or formula (III-b) is produced by reacting a cyclic bis(aminol)ether compound represented by formula (I) and an acetone derivative represented by formula (II) in the presence of at least one substance selected from the group consisting of protonic acids, Lewis acids, acid halides and dialkyl sulfuric acids.Type: GrantFiled: October 10, 2007Date of Patent: May 8, 2012Assignee: Nippon Soda Co., Ltd.Inventors: Hirohito Oooka, Yasushi Shibata, Hiroki Inoue, Tsutomu Imagawa
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Publication number: 20120071656Abstract: The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid.Type: ApplicationFiled: October 17, 2011Publication date: March 22, 2012Applicant: Nippon Soda Co., Ltd.Inventors: Yasushi SHIBATA, Tsutomu Imagawa
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Publication number: 20100286398Abstract: There are provided, according to the present invention, a method for producing a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative, the method characterized in that a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative or a mixture of the trans- and cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivatives is isomerized in the presence of an aluminum compound represented by a formula Al(OR1)3 (wherein R1 represents a hydrocarbon group in which a carbon atom having an oxygen atom bonded thereto is a secondary carbon atom). In the process, a ketone compound may be further added, in addition to the aluminum compound.Type: ApplicationFiled: August 27, 2008Publication date: November 11, 2010Applicant: NIPPON SODA CO., LTD.Inventors: Hiroshi Hakuta, Tsutomu Imagawa, Hirohito Oooka, Shinya Fukuhara
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Publication number: 20100121054Abstract: The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid.Type: ApplicationFiled: April 24, 2007Publication date: May 13, 2010Applicant: Nippon Soda Co., Ltd.Inventors: Yasushi Shibata, Tsutomu Imagawa
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Publication number: 20100004455Abstract: Provided is a method for producing a piperidin-4-one derivative useful as an intermediate for agricultural chemicals or pharmaceutical products. A piperidin-4-one derivative represented by formula (III-a) or formula (III-b) is produced by reacting a cyclic bis(aminol)ether compound represented by formula (I) and an acetone derivative represented by formula (II) in the presence of at least one substance selected from the group consisting of protonic acids, Lewis acids, acid halides and dialkyl sulfuric acids.Type: ApplicationFiled: October 10, 2007Publication date: January 7, 2010Inventors: Hirohito Oooka, Yasushi Shibata, Hiroki Inoue, Tsutomu Imagawa
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Patent number: 7468174Abstract: A method for producing chlorosulfonyl isocyanate by reaction of sulfur trioxide with cyanogen chloride, wherein chlorosulfonyl isocyanate or a solution including chlorosulfonyl isocyanate is used as a reaction solvent, sulfur trioxide and cyanogen chloride which are respectively diluted with the chlorosulfonyl isocyanate or the solution including chlorosulfonyl isocyanate are added at the same time to a reaction system in an almost equimolar amount under reflux. By the production method of present invention, chlorosulfonyl isocyanate can be produced from sulfur trioxide and cyanogen chloride in which the yield of the chlorosulfonyl isocyanate is high, the method has excellent operability, number of equipments is reduced, and time for controlling the temperature is saved.Type: GrantFiled: December 15, 2004Date of Patent: December 23, 2008Assignee: Nippon Soda Co., Ltd.Inventors: Mutsumi Sugawara, Tsutomu Imagawa, Fumitaka Masui
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Publication number: 20070286789Abstract: A method for producing chlorosulfonyl isocyanate by reaction of sulfur trioxide with cyanogen chloride, wherein chlorosulfonyl isocyanate or a solution including chlorosulfonyl isocyanate is used as a reaction solvent, sulfur trioxide and cyanogen chloride which are respectively diluted with the chlorosulfonyl isocyanate or the solution including chlorosulfonyl isocyanate are added at the same time to a reaction system in an almost equimolar amount under reflux. By the production method of present invention, chlorosulfonyl isocyanate can be produced from sulfur trioxide and cyanogen chloride in which the yield of the chlorosulfonyl isocyanate is high, the method has excellent operability, number of equipments is reduced, and time for controlling the temperature is saved.Type: ApplicationFiled: December 15, 2004Publication date: December 13, 2007Applicant: Nippon Soda Co., Ltd.Inventors: Mutsumi Sugawara, Tsutomu Imagawa, Fumitaka Masui
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Publication number: 20040019221Abstract: A process (1) for the preparation of 4-cyanoacetylpyrazoles of the general formula (I) wherein R1 is C1-6 alkyl, R2 is C1-6 alkyl or C1-6 haloalkyl, and X is hydrogen or C1-6 alkyl which comprises using a pyrazolecarboxylic acid halide and a cyanoacetate ester; a process (2) for the preparation of the same which comprises using a pyrazolecarboxylic acid and a cyanoacetate ester; a process (3) for the preparation of the same which comprises using a pyrazolecarbonitrile; and a process (4) for the preparation of the same which comprises using a haloacetylpyrazole. Furthermore, an industrially advantageous process for preparing pyrazolecarboxylic acids useful as intermediates in the above processes.Type: ApplicationFiled: February 6, 2003Publication date: January 29, 2004Inventors: Tomio Yagihara, Tsutomu Imagawa, Shigemi Suga, Masami Hatano, Yasushi Shibata, Tetsushi Ookuchi, Isamu Kasahara