Patents by Inventor Tsutomu Kagiya

Tsutomu Kagiya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7462601
    Abstract: An ameliorating agent for cancer chemotherapy is disclosed, which comprises a chromanol glycoside represented by the following general formula (1) (wherein R1, R2, R3, and R4, which are identical or different from each other, stand for a hydrogen atom or a lower alkyl group, R5 stands for a hydrogen atom, a lower alkyl group, or a lower acyl group, X stands for a monosaccharide residue or an oligosaccharide residue optionally having the hydrogen atom of the hydroxyl group in the saccharide residue substituted with a lower alkyl group or a lower acyl group, n is an integer in the range of 0-6, and m is an integer in the range of 1-6). According to this invention, a novel ameliorating agent for cancer chemotherapy is provided which acts safely and effectively in a small dosage to enhance the carcinostatic action of an anti-cancer agent in cancer chemotherapy and repressing side effects by cancer chemotherapy as well.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: December 9, 2008
    Inventors: Tsutomu Kagiya, Hironobu Murase, Nina Petrovna Konovalova, Ludmila Mihailovna Volkova, Nataliya Yurievna Lugovskaya, Lubov Sergeevna Vasilieva
  • Publication number: 20050215492
    Abstract: An ameliorating agent for cancer chemotherapy is disclosed, which comprises a chromanol glucoside represented by the following general formula (1) (wherein R1, R2, R3, and R4, which are identical or different from each other, stand for a hydrogen atom or a lower alkyl group, R5 stands for a hydrogen atom, a lower alkyl group, or a lower acyl group, X stands for a monosaccharide residue or an oligosaccharide residue optionally having the hydrogen atom of the hydroxyl group in the saccharide residue substituted with a lower alkyl group or a lower acyl group, n is an integer in the range of 0-6, and m is an integer in the range of 1-6). According to this invention, a novel ameliorating agent for cancer chemotherapy is provided which acts safely and effectively in a small dosage to enhance the carcinostatic action of an anti-cancer agent in cancer chemotherapy and repressing side effects by cancer chemotherapy as well.
    Type: Application
    Filed: March 26, 2004
    Publication date: September 29, 2005
    Applicant: Tsutomu Kagiya
    Inventors: Tsutomu Kagiya, Hironobu Murase, Nina Konovalova, Ludmila Volkova, Nataliya Lugovskaya, Lubov Vasilieva
  • Patent number: 5304654
    Abstract: A 2-nitroimidazole compound of the formula: ##STR1## wherein R.sub.f is a fluorine-containing organic group which has at least one fluorine atom on a carbon atom which bonds to the nitrogen atom of the imidazole ring or a carbon atom which bonds to said carbon atom and a radiosensitizer comprising said nitroimidazole derivative.
    Type: Grant
    Filed: September 9, 1991
    Date of Patent: April 19, 1994
    Assignees: Yasunori Nishijima, Daikin Industries, Ltd.
    Inventors: Tsutomu Kagiya, Mitsuyuki Abe, Seiichi Nishimoto, Yuta Shibamoto, Kazuhiro Shimokawa, Yorisato Hisanaga, Tatsuo Nakada, Toru Yoshizawa
  • Patent number: 4977273
    Abstract: A 2-nitroimidazole derivative of the formula: ##STR1## wherein R.sub.f is a group of the following formula (II) or (III):--CH.sub.2 CFXCH.sub.2 OR.sub.1 (II)wherein X is a hydrogen atom or a halogen atom; R.sub.1 is a group of the formula: ##STR2## wherein R.sub.2 is a hydrogen atom, a hydroxyl group, a C.sub.1 -C.sub.3 alkyl group, a C.sub.2 -C.sub.4 acyl group, benzylidene or acetonide; R.sub.3 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; Z is a hydrogen atom, COOY, COOR.sub.3, CONHOY, CONR.sub.4 R.sub.5 (wherein R.sub.4 and R.sub.5 are hydroxyl group-containing C.sub.1 -C.sub.3 alkyl groups or hydrogen atoms; Y is a hydrogen atom or a monovalent metal atom), an amino group, a hydroxyl group or OR.sub.3 ; l is an integer of 1 to 3; o is an integer of 0 to 3; p is an integer of 0 to 2; q is an integer of 0 to 3; m and n are integers of 0 to 4; and 1.ltoreq.m+n.ltoreq.4 or ##STR3## wherein R.sub.3, X and p are the same as defined above; Z' is the same as Z or is OCOOCH.sub.
    Type: Grant
    Filed: December 12, 1989
    Date of Patent: December 11, 1990
    Assignees: Kyoto University of Honmachi, Taisho Pharmaceutical Co., Ltd., Daikin Industries, Ltd.
    Inventors: Tsutomu Kagiya, Mitsuyuki Abe, Seiichi Nishimoto, Yuta Shibamoto, Susumu Otomo, Tohru Tanami, Kazuhiro Shimokawa, Toru Yoshizawa, Yorisato Hisanaga
  • Patent number: 4927941
    Abstract: A nitroazole derivative of the formula:NA--R.sub.f (I)wherein NA is 3-nitro-1,2,4-triazol-l-yl and R.sub.f is a fluorine-containing organic group which is useful as a radiosensitizer.
    Type: Grant
    Filed: June 9, 1988
    Date of Patent: May 22, 1990
    Assignee: Yasunori Nishijima & Daikin Industries Ltd.
    Inventors: Tsutomu Kagiya, Mitsuyuki Abe, Seiichi Nishimoto, Yuta Shibamoto, Kazuhiro Shimokawa, Yorisato Hisanaga, Tatsuo Nakada, Toru Yoshizawa
  • Patent number: 4820844
    Abstract: A radiation sensitizer of the present invention contains a particular nitrotriazole compound as an active ingredient and accelerates inactivation of intractable hypoxic cells in a malignant tumor by irradiation.
    Type: Grant
    Filed: August 12, 1986
    Date of Patent: April 11, 1989
    Assignees: Adeka Argus Chemical Co., Ltd., Kyoto University
    Inventors: Tsutomu Kagiya, Motonobu Minagawa, Yutaka Nakahara, Ryoji Kimura, Tsuneo Tsubakimoto, Ryoichi Oshiumi, Koichi Sakano
  • Patent number: 4062998
    Abstract: Electric wire coated by a non-flammable resin, characterized in that the resin is composed of two layers, the degrees of crosslinking of which are different from each other, and the gel percent of the outer portion of the resin is lower than that of the inner portion of the resin is disclosed.
    Type: Grant
    Filed: April 9, 1976
    Date of Patent: December 13, 1977
    Assignees: Japan Atomic Energy Research Institute, Kishimoto Sangyo Co., Ltd.
    Inventors: Miyuki Hagiwara, Masayoshi Sohara, Kunio Araki, Tsutomu Kagiya
  • Patent number: 3979482
    Abstract: The oxidation of a high polymer such as polyvinyl chloride or polyolefin, which oxidation causes cleavages of carbon-carbon bonds in the main chains thereof to degrade the high polymer into lower molecular weight compounds, is remarkably accelerated when the high polymer is impregnated with a halogenated compound having a carbonyl group or carbonyl groups and exposed to sunlight or is irradiated with ultraviolet radiation in an ambient atmosphere of oxygen or a gas containing oxygen. This acceleration of the oxidation makes possible easy destruction of a shaped article made of such a high polymer.
    Type: Grant
    Filed: November 29, 1974
    Date of Patent: September 7, 1976
    Assignees: Tsutomu Kagiya, Shinetsu Chemical Company, Tekkosha Co., Ltd.
    Inventors: Tsutomu Kagiya, Kunihiko Miyoshi, Katsuo Takemoto