Patents by Inventor Tsutomu Mochizuki

Tsutomu Mochizuki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220273692
    Abstract: An object is to provide a drug which is useful in treating a nervous system disease. A drug containing vitamin B12 as an active ingredient according to the present invention has an M2 macrophage/microglia induction promoting effect, an M1 macrophage/microglia induction inhibiting effect, a nerve regeneration promoting effect, and the like and is very useful as a therapeutic agent for a nervous system disease, and particularly useful as a therapeutic agent for a central nervous system disease such as cerebral infarction, dementia, or spinal cord injury.
    Type: Application
    Filed: May 19, 2022
    Publication date: September 1, 2022
    Applicants: OSAKA UNIVERSITY, NIPPON ZOKI PHARMACEUTICAL CO., LTD.
    Inventors: Hiroyuki TANAKA, Hideki YOSHIKAWA, Hideki MOCHIZUKI, Tsuyoshi MURASE, Tsutomu SASAKI, Kousuke BABA, Toru IWAHASHI, Mitsuru NAIKI
  • Patent number: 11369626
    Abstract: A method of treating a central nervous system disease, the method including administering an agent including a therapeutically effective amount of vitamin B12 to a patient with a central nervous system disease to treat the central nervous system disease. This disclosure also relates to a method of promoting M2 macrophage/microglia induction, inhibiting M1 macrophage/microglia induction, and/or reducing the ratio of M1 macrophage/microglia to M2 macrophage/microglia in a patient in need thereof, the method including administering an agent including a therapeutically effective amount of vitamin B12 to the patient to promote M2 macrophage/microglia induction, inhibit M1 macrophage/microglia induction, and/or reduce the ratio of M1 macrophage/microglia to M2 macrophage/microglia. This disclosure also relates to a pharmaceutical product including vitamin B12.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: June 28, 2022
    Assignees: OSAKA UNIVERSITY, NIPPON ZOKI PHARMACEUTICAL CO., LTD.
    Inventors: Hiroyuki Tanaka, Hideki Yoshikawa, Hideki Mochizuki, Tsuyoshi Murase, Tsutomu Sasaki, Kousuke Baba, Toru Iwahashi, Mitsuru Naiki
  • Patent number: 10801521
    Abstract: A heating device for heating a component in a turbo molecular pump for exhausting a gas includes a heat transfer member, a heater, a first seal member and a second seal member. The heat transfer member is provided in an opening of a housing of the turbo molecular pump and has one end fixed to the component and the other end exposed to an outside. The heater in the heat transfer member heats the component through the heat transfer member. The first seal member is provided between the heat transfer member and the opening along an outer peripheral surface of the heat transfer member. The second seal member between the heat transfer member and the opening is located close to the component compared to the first seal member. The second seal member suppresses movement of radicals in a gas into a space between the heat transfer member and the opening.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: October 13, 2020
    Assignee: TOKYO ELECTRON LIMITED
    Inventors: Tsutomu Mochizuki, Kazuhiro Chiba, Ryo Murakami, Kazuyuki Miura
  • Publication number: 20170298958
    Abstract: A heating device for heating a component in a turbo molecular pump for exhausting a gas includes a heat transfer member, a heater, a first seal member and a second seal member. The heat transfer member is provided in an opening of a housing of the turbo molecular pump and has one end fixed to the component and the other end exposed to an outside. The heater in the heat transfer member heats the component through the heat transfer member. The first seal member is provided between the heat transfer member and the opening along an outer peripheral surface of the heat transfer member. The second seal member between the heat transfer member and the opening is located close to the component compared to the first seal member. The second seal member suppresses movement of radicals in a gas into a space between the heat transfer member and the opening.
    Type: Application
    Filed: April 12, 2017
    Publication date: October 19, 2017
    Applicant: TOKYO ELECTRON LIMITED
    Inventors: Tsutomu MOCHIZUKI, Kazuhiro CHIBA, Ryo MURAKAMI, Kazuyuki MIURA
  • Patent number: 9492842
    Abstract: Provided is: a cell culture membrane, which is free from materials derived from living organisms, can easily be industrially mass-produced, exhibits superior long-term storage properties and chemical resistance, has excellent cell adhesion properties and long-term culture properties and is capable of replicating a cell adhesion morphology that is similar to that of collagen derived from living organisms and being used for conventional cell cultivation. Also provided are a cell culture substrate, and a method for manufacturing the cell culture substrate. In the present invention, as a cell adhesion layer, a polymer membrane represented by formula (I) is formed on the base of a cell culture substrate so as to have a membrane thickness equal to or greater than 0.2 ?m (in the formula, R1 and R2 represent a —(CH2)n—NH2 moiety (n is an integer of 1-10 inclusive.) or H, with at least one of R1 and R2 being a —(CH2)n—NH2 moiety. Moreover, l and m are positive integers expressing polymerization degree).
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: November 15, 2016
    Assignees: KISCO LTD., DAISANKASEI CO., LTD., The University of Tokyo
    Inventors: Yasuo Yoshimoto, Kentaro Kamimae, Yuki Tanabe, Taku Oguni, Takashi Inoue, Tsutomu Mochizuki, Makoto Hirama, Teruo Fujii, Hiroshi Kimura, Hideto Tozawa
  • Patent number: 8968779
    Abstract: Disclosed is a controlled release nucleated tablet which is composed of an inner nucleus and an outer layer that covers the inner nucleus and is capable of maintaining the level of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in the blood to a certain value or higher for a long period of time. The controlled release nucleated tablet is characterized in that the inner nucleus contains 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and the outer layer contains 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and a gel-forming water-soluble polymer that is in an amount of 16 (w/w) % or more relative to the weight of the outer layer.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: March 3, 2015
    Assignee: Teijin Pharma Limited
    Inventors: Kentaro Fujinaga, Susumu Maruo, Hideaki Nakamura, Kenji Sunagawa, Tsutomu Mochizuki, Michiharu Kageyama
  • Publication number: 20140212974
    Abstract: Provided is: a cell culture membrane, which is free from materials derived from living organisms, can easily be industrially mass-produced, exhibits superior long-term storage properties and chemical resistance, has excellent cell adhesion properties and long-term culture properties and is capable of replicating a cell adhesion morphology that is similar to that of collagen derived from living organisms and being used for conventional cell cultivation. Also provided are a cell culture substrate, and a method for manufacturing the cell culture substrate. In the present invention, as a cell adhesion layer, a polymer membrane represented by formula (I) is formed on the base of a cell culture substrate so as to have a membrane thickness equal to or greater than 0.2 ?m (in the formula, R1 and R2 represent a —(CH2)n—NH2 moiety (n is an integer of 1-10 inclusive.) or H, with at least one of R1 and R2 being a —(CH2)n—NH2 moiety. Moreover, l and m are positive integers expressing polymerization degree).
    Type: Application
    Filed: June 22, 2012
    Publication date: July 31, 2014
    Applicants: KISCO LTD., THE UNIVERSITY OF TOKYO, DAISANKASEI CO., LTD.
    Inventors: Yasuo Yoshimoto, Kentaro Kamimae, Yuki Tanabe, Taku Oguni, Takashi Inoue, Tsutomu Mochizuki, Makoto Hirama, Teruo Fujii, Hiroshi Kimura, Hideto Tozawa
  • Publication number: 20130089609
    Abstract: Disclosed is a controlled release nucleated tablet which is composed of an inner nucleus and an outer layer that covers the inner nucleus and is capable of maintaining the level of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in the blood to a certain value or higher for a long period of time. The controlled release nucleated tablet is characterized in that the inner nucleus contains 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and the outer layer contains 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and a gel-forming water-soluble polymer that is in an amount of 16 (w/w) % or more relative to the weight of the outer layer.
    Type: Application
    Filed: June 15, 2011
    Publication date: April 11, 2013
    Applicant: TEIJIN PHARMA LIMITED
    Inventors: Kentaro Fujinaga, Susumu Maruo, Hideaki Nakamura, Kenji Sunagawa, Tsutomu Mochizuki, Michiharu Kageyama
  • Patent number: 7763318
    Abstract: A method for improving the heat stability of polyparaxylylene and a derivative film thereof to improve the heat resistance of the polyparaxylylene and the derivative film thereof without deteriorating deposition characteristics or profitability, and a polyparaxylylene derivative whose heat resistance is improved are provided. When the polyparaxylylene or the derivative film thereof represented by a below-described general formula 1 is formed by a chemical vapor deposition method, an amino-(2.2)-paracyclophane compound represented by a below-described general formula 3 is mixed in a (2.2)-paracyclophane compound represented by a below-described general formula 2 to form a film. (In the formula 1, X1 and X2 designate hydrogen, lower alkyl or halogen. X1 and X2 may be the same or different. n represents a degree of polymerization.) (In the formula 2, X1 and X2 have the same meanings as those of the formula 1.) (In the formula 3, X3 designates hydrogen or a lower alkyl group.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: July 27, 2010
    Assignee: Daisankasei Co., Ltd.
    Inventors: Hiroshi Maruyama, Tsutomu Mochizuki, Takashi Inoue
  • Publication number: 20100034970
    Abstract: A chemical vapor deposition apparatus includes a charging section 10 for charging a feedstock material for vapor deposition, a decomposition oven 2 for decomposing a feedstock material for vapor deposition, an opening/closing valve 4 for interconnecting the charging section 10 and the decomposition oven 2, and a polymerization section 3 for polymerizing the feedstock material decomposed by the decomposition oven for depositing a coating film on the surface of a substrate. The feedstock material for vapor deposition charged into the charging section 10 is vaporized, and the so vaporized feedstock material is delivered to the decomposition oven 2 by opening the opening/closing valve 4 to deposit the coating film.
    Type: Application
    Filed: July 28, 2006
    Publication date: February 11, 2010
    Applicants: DAISANKASEI CO., LTD., KISCO LTD.
    Inventors: Tsutomu Mochizuki, Takashi Inoue, Kazuyoshi Uetake
  • Publication number: 20070105997
    Abstract: A method for improving the heat stability of polyparaxylylene and a derivative film thereof to improve the heat resistance of the polyparaxylylene and the derivative film thereof without deteriorating deposition characteristics or profitability, and a polyparaxylylene derivative whose heat resistance is improved are provided. When the polyparaxylylene or the derivative film thereof represented by a below-described general formula 1 is formed by a chemical vapor deposition method, an amino-(2.2)-paracyclophane compound represented by a below-described general formula 3 is mixed in a (2.2)-paracyclophane compound represented by a below-described general formula 2 to form a film. (In the formula 1, X1 and X2 designate hydrogen, lower alkyl or halogen. X1 and X2 may be the same or different. n represents a degree of polymerization.) (In the formula 2, X1 and X2 have the same meanings as those of the formula 1.) (In the formula 3, X3 designates hydrogen or a lower alkyl group.
    Type: Application
    Filed: December 19, 2003
    Publication date: May 10, 2007
    Applicant: DAISANKASEI CO., LTD.
    Inventors: Hiroshi Maruyama, Tsutomu Mochizuki, Takashi Inoue
  • Patent number: 6291072
    Abstract: A semiconductor device is provided with an interlayer insulating film consisting essentially of poly-&agr;,&agr;-difluoroparaxylylene. The interlayer insulating film can have a low relative dielectric constant of from 2.1 to 2.7.
    Type: Grant
    Filed: January 12, 1999
    Date of Patent: September 18, 2001
    Assignees: Kishimoto Sangyo Co., Ltd., Daisankasei Co., Ltd.
    Inventors: Hisao Kimoto, Tsutomu Mochizuki
  • Patent number: 6172958
    Abstract: In order to provide an optical pick-up capable of carrying out write and read operations of information signals with respect to plural kinds of optical discs in which thicknesses of transparent bases are different from each other and simple in configuration, a first object lens 7a for converging light beams from a first light source onto an optical disc 101 of the first kind and a second object lens 7b for converging light beams from a second light source 6 onto an optical disc 102 of the second kind are provided on the same lens bobbin 8. The lens bobbin 8 is movably supported by the columnar support shaft and is caused to undergo movement operation by magnetic circuit.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: January 9, 2001
    Assignee: Sony Corporation
    Inventors: Tsutomu Mochizuki, Yutaka Sugawara
  • Patent number: 6097690
    Abstract: A disc player provided with an optical pick-up including plural object lens so that write and read operations of information signals can be carried out with respect to plural kinds of discs in which thicknesses of transparent bases are different from each other. In order that tracking error signal can be satisfactorily detected even in the case where either one of object lenses is used, a biaxial actuator 3 for supporting an object lens 5 moved on a line which is off the central axis C of a spindle motor 17 is disposed in a manner inclined by a predetermined angle .theta. with respect to the axis of a guide shaft 18, and movement operation direction of the object lens 5 is caused to be close to the direction perpendicular to recording tracks of the optical disc caused to undergo rotational operation by the spindle motor 17.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: August 1, 2000
    Assignee: Sony Corporation
    Inventors: Tsutomu Mochizuki, Katsuhiko Yamada
  • Patent number: 6044048
    Abstract: An optical pickup in an optical disc device configured for recording and/or reproducing signal on or from an optical disc. The optical pickup is configured for setting the orientation of a bending mirror directing the optical path of a light beam radiated from a light source towards the optical disc so that the optical path between the reflecting surface of the mirror and the photodetector is approximately 45 relative to the recording track of the optical disc. With the above configuration of the optical pickup, focusing error signals and tracking error signals of plural discs of different types can be detected by a common photodetector.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: March 28, 2000
    Assignee: Sony Corporation
    Inventors: Hiroshi Oinoue, Tsutomu Mochizuki
  • Patent number: 5787062
    Abstract: A disc-thickness-and-warp detecting apparatus includes a light source for emitting rays onto a peripheral portion of an optical disc; a photo-detector having a plurality of photo-detecting portions separated corresponding to the direction of tracks formed on the disc, for detecting rays emitted from the light source and reflected by the disc; an adding circuit for generating a sum-signal by adding the detection-signals from the respective photo-receiving portions; and a subtracting circuit for generating a difference-signal by performing the subtraction of the detection-signals from the respective photo-receiving portions. The apparatus uses such common detecting means to detect the distance between the disc surface and the signal-recording surface and a warp of the disc.
    Type: Grant
    Filed: October 17, 1996
    Date of Patent: July 28, 1998
    Assignee: Sony Corporation
    Inventor: Tsutomu Mochizuki
  • Patent number: 5574061
    Abstract: A benzopyran derivative represented by the formula (I) or its pharmaceutically acceptable salt: ##STR1## wherein either one of X and Y stands for the following formula ##STR2## and the other one of X and Y and R.sup.1 -R.sup.10 stand for various substituents,and ACAT inhibitor, anti-hyperlipidemia agent and anti-atherosclerosis agent compositions containing the same as an active ingredient.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: November 12, 1996
    Assignee: Teijin Limited
    Inventors: Tatsuki Shiota, Takumi Takeyasu, Kenichiro Kataoka, Tsutomu Mochizuki, Hirofumi Tanabe, Mikio Ota, Hisao Yamaguchi
  • Patent number: 5496853
    Abstract: Pharmaceutical compositions containing a benzoxazole compound and a 2,3-dihydrobenzofuran compound represented by the following formula (I) and its pharmaceutically acceptable salt: ##STR1## In the formula, any one of P, Q, R and S is a group represented by the formula: ##STR2## and R.sub.1, R.sub.2 and the reining three substituents out of the substituents P to S each independently stand for various substituents. These compositions are used as an ATCAT inhibitor or for treating hyperlipidemia and atherosclerosis.
    Type: Grant
    Filed: April 26, 1995
    Date of Patent: March 5, 1996
    Assignee: Teijin Limited
    Inventors: Tatsuki Shiota, Takumi Takeyasu, Kenichiro Kataoka, Tsutomu Mochizuki, Hirofumi Tanabe, Mikio Ota, Masatoshi Kano, Hisao Yamaguchi
  • Patent number: 4969363
    Abstract: In an electromagnetic flowmeter one of two electrodes mounted on a measuring pipe is impressed with an electrical pulse synchronous with the switching of an excitation currrent, thereby detecting the voltage drop across the electrical resistance of a fluid, such that both the conductivity and the flow rate of the fluid are measureable at the same time.
    Type: Grant
    Filed: March 28, 1989
    Date of Patent: November 13, 1990
    Assignee: Aichi Tokei Denki Co., Ltd.
    Inventor: Tsutomu Mochizuki
  • Patent number: D433015
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: October 31, 2000
    Assignee: Sony Corporation
    Inventor: Tsutomu Mochizuki