Patents by Inventor Tsutomu Seito
Tsutomu Seito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180051071Abstract: Provided is an antibody or an immunologically reactive fragment thereof which targets exclusively an A? having a specific turn structure of A? (a toxic conformer of A?). Also provided are a medicinal composition comprising, as an active ingredient, an antibody that specifically recognizes a toxic conformer of A?, a kit for assaying a toxic conformer of A?, a diagnostic agent for Alzheimer's disease, etc.Type: ApplicationFiled: December 14, 2015Publication date: February 22, 2018Inventors: Kazuhiro Irie, Kazuma Murakami, Takahiko Shimizu, Naotaka Izuo, Tsutomu Seito
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Publication number: 20150219644Abstract: The present invention provides a method of testing plasma and/or serum of a test subject for determining the pathology or onset risk of acute coronary syndrome, including (1) a step of measuring a soluble amyloid ? precursor protein (sAPP) 770 level of plasma and/or serum of a test subject; and (2) a step of relating the plasma and/or serum sAPP770 level(s) measured in (1) to the pathology or onset risk of acute coronary syndrome.Type: ApplicationFiled: June 6, 2013Publication date: August 6, 2015Applicant: RIKENInventors: Shinobu Kitazume, Akiomi Yoshihisa, Takayoshi Yamaki, Yasuchika Takeishi, Yasuhiro Hashimoto, Naoyuki Taniguchi, Rie Imamaki, Naomasa Yamamoto, Tsutomu Seito
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Publication number: 20140135483Abstract: The present invention addresses the problem of providing a novel substance capable of interfering with various functions of integrin ?4, and/or providing a novel substance capable of interfering with both integrin ?4 and integrin ?9. The present invention provides an integrin ?4 mutant peptide having one portion of the extracellular domain of human integrin ?4, and the like, and in concrete terms relates to a peptide and the like having the amino acid sequence of Sequence No. 4 through 9, and a pharmaceutical composition comprising as the active ingredient the same peptide.Type: ApplicationFiled: June 28, 2012Publication date: May 15, 2014Applicants: GENE TECHNO SCIENCE CO., LTD., IMMUNO-BIOLOGICAL LABORATORIES CO., LTD.Inventors: Tsutomu Seito, Shigeyuki Kon
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Patent number: 8710193Abstract: Provided is a therapeutic method exclusively targeting an amyloid ? protein (A?) having a specific turn structure of A?. Specifically provided is an antibody which specifically recognizes an amyloid ? having a turn structure at amino acids positions 22 and 23. Also provided are a medicinal composition comprising, as the active ingredient, an antibody specifically recognizing a toxic conformer of amyloid ?, an assay kit for a toxic conformer of amyloid ?, a diagnostic for Alzheimer's disease, etc.Type: GrantFiled: October 18, 2010Date of Patent: April 29, 2014Assignees: Kyoto University, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Immuno-Biological Laboratories Co., Ltd.Inventors: Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
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Patent number: 8481497Abstract: [PROBLEMS] To provide a technique which enables an effective antibody therapy for cancer which targets for FGFR1 without the need of using any effective antibody having high specificity and a potent cell-killing activity. [MEANS FOR SOLVING PROBLEMS] Disclosed are: a therapeutic agent for cancer, which comprises an enhancer of the expression of a fibroblast growth factor receptor-1 and an anti-fibroblast growth factor receptor-1 antibody; and a method for the treatment of cancer using the therapeutic agent.Type: GrantFiled: May 29, 2008Date of Patent: July 9, 2013Assignees: Sapporo Medical University, The University of TokyoInventors: Kohzoh Imai, Shigeru Sasaki, Tsutomu Seito
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Patent number: 8329414Abstract: The purpose of the invention is to provide an antibody which recognizes OPN N-half but does not recognize the full-length OPN, and its use. A monoclonal antibody which is characterized in that it recognizes a protein or polypeptide in which the C-terminal amino acid sequence is YGLR (SEQ ID NO: 1) and it substantially does not recognize a protein or polypeptide which has an amino acid sequence of YGLR outside of the C-terminal, as well as a method for measuring OPN N-half utilizing the said antibody, a method for diagnosing diseases relating to OPN N-half, a method for judging the severity of said disease, and a method for treating said diseases, are provided.Type: GrantFiled: May 11, 2011Date of Patent: December 11, 2012Assignee: Immuno-Biological Laboratories Co., Ltd.Inventors: Hiroko Kobayashi, Masahiro Hasegawa, Tsutomu Seito
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Publication number: 20120219552Abstract: Provided is a therapeutic method exclusively targeting an amyloid ? protein (A?) having a specific turn structure of A?. Specifically provided is an antibody which specifically recognizes an amyloid ? having a turn structure at amino acids positions 22 and 23. Also provided are a medicinal composition comprising, as the active ingredient, an antibody specifically recognizing a toxic conformer of amyloid ?, an assay kit for a toxic conformer of amyloid ?, a diagnostic for Alzheimer's disease, etc.Type: ApplicationFiled: October 18, 2010Publication date: August 30, 2012Applicants: KYOTO UNIVERSITY, IMMUNO-BIOLOGICAL LABORATORIES CO., LTD., TOKYO METROPOLITAN GERIATRIC HOSPITAL AND INSTITUTE OF GERONTOLOGYInventors: Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
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Publication number: 20110312000Abstract: The purpose of the invention is to provide an antibody which recognizes OPN N-half but does not recognize the full-length OPN, and its use. A monoclonal antibody which is characterized in that it recognizes a protein or polypeptide in which the C-terminal amino acid sequence is YGLR (SEQ ID NO: 1) and it substantially does not recognize a protein or polypeptide which has an amino acid sequence of YGLR outside of the C-terminal, as well as a method for measuring OPN N-half utilizing the said antibody, a method for diagnosing diseases relating to OPN N-half, a method for judging the severity of said disease, and a method for treating said diseases, are provided.Type: ApplicationFiled: May 11, 2011Publication date: December 22, 2011Applicant: IMMUNO-BIOLOGICAL LABORATORIES CO., LTD.Inventors: Hiroko Kobayashi, Masahiro Hasegawa, Tsutomu Seito
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Patent number: 7981672Abstract: The purpose of the invention is to provide an antibody which recognizes OPN N-half but does not recognize the full-length OPN, and its use. A monoclonal antibody which is characterized in that it recognizes a protein or polypeptide in which the C-terminal amino acid sequence is YGLR (SEQ ID NO: 1) and it substantially does not recognize a protein or polypeptide which has an amino acid sequence of YGLR outside of the C-terminal, as well as a method for measuring OPN N-half utilizing the said antibody, a method for diagnosing diseases relating to OPN N-half, a method for judging the severity of said disease, and a method for treating said diseases, are provided.Type: GrantFiled: September 11, 2007Date of Patent: July 19, 2011Assignee: Immuno-Biological Laboratories Co., Ltd.Inventors: Hiroko Kobayashi, Masahiro Hasegawa, Tsutomu Seito
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Publication number: 20110129524Abstract: [Problems] To provide a technique which enables an effective antibody therapy for cancer which targets for FGFR1 without the need of using any effective antibody having high specificity and a potent cell-killing activity. [Means for Solving Problems] Disclosed are: a therapeutic agent for cancer, which comprises an enhancer of the expression of a fibroblast growth factor receptor-1 and an anti-fibroblast growth factor receptor-1 antibody; and a method for the treatment of cancer using the therapeutic agent.Type: ApplicationFiled: May 29, 2008Publication date: June 2, 2011Applicants: IMMUNO-BIOLOGICAL LABORATORIES CO., LTD, SAPPOROR MEDICAL UNIVERSITYInventors: Kohzoh Imai, Shigeru Sasaki, Tsutomu Seito
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Publication number: 20100323375Abstract: Disclosed are: an agent, an apparatus and a method for the diagnosis of a disease associated with the abnormality in ?-secretase; a method for providing information for the diagnosis of a disease associated with the abnormality in ?-secretase; a method for monitoring the condition or the degree of progression of a disease associated with the abnormality in ?-secretase; and a method for determining the therapeutic effect of a therapeutic agent on a disease associated with the abnormality in ?-secretase. More specifically disclosed are: a diagnostic agent for a disease associated with the abnormality in ?-secretase, which comprises an antibody capable of recognizing a digestion product of an alcadein with ?-secretase or ?-secretase or a fragment of the antibody; and others.Type: ApplicationFiled: December 5, 2008Publication date: December 23, 2010Applicants: IMMUNO-BIOLOGICAL LABORATORIES CO., LTD., NATIONAL UNIVERSITY CORPORATIONInventors: Masahiro Maeda, Tsutomu Seito, Toshiharu Suzuki, Saori Hata
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Publication number: 20100111939Abstract: The purpose of the invention is to provide an antibody which recognizes OPN N-half but does not recognize the full-length OPN, and its use. A monoclonal antibody which is characterized in that it recognizes a protein or polypeptide in which the C-terminal amino acid sequence is YGLR (SEQ ID NO: 1) and it substantially does not recognize a protein or polypeptide which has an amino acid sequence of YGLR outside of the C-terminal, as well as a method for measuring OPN N-half utilizing the said antibody, a method for diagnosing diseases relating to OPN N-half, a method for judging the severity of said disease, and a method for treating said diseases, are provided.Type: ApplicationFiled: September 11, 2007Publication date: May 6, 2010Applicant: Immuno-Biological Laboratories Co., LtdInventors: Hiroko Kobayashi, Masahiro Hasegawa, Tsutomu Seito