Abstract: An antibody has an antagonistic effect against IL-33. An isolated human anti-IL-33 neutralizing monoclonal antibody has framework regions with amino acid sequences from a germline, including combinations and fragments of such sequences. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce the foregoing human anti-IL-33 neutralizing monoclonal antibodies having framework regions.

Abstract: An antibody has an antagonistic effect against IL-33. In particular an isolated human anti-IL-33 neutralizing monoclonal antibody has framework regions with amino acid sequences from a germline, including combinations and fragments of such sequences. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce the foregoing human anti-IL-33 neutralizing monoclonal antibodies having framework regions.

Abstract: A magnetic fluid drive device for driving a magnetic fluid having temperature sensitivity in accordance with heat reception, the magnetic fluid drive device includes: a heat receiver having a flow channel through which the magnetic fluid flows, to receive heat; a magnet member disposed outside the flow channel to generate a magnetic field; and a drive mechanism that changes a position of the magnet member with respect to the heat receiver from a first position that is adjacent to the heat receiver with the magnet member applying the magnetic field to the magnetic fluid in the flow channel.

Abstract: A phosphor wheel includes a disk-shaped member that is rotated about a rotation axis, and a phosphor layer disposed on an outer face of the disk-shaped member. The disk-shaped member has a hollow-box structure that forms an enclosed space. A coolant is sealed in the enclosed space. The coolant evaporates to a gas state from a liquid state at more than or equal to a predetermined temperature. In the liquid state, a volume of the coolant is smaller than a capacity of the enclosed space. A light conversion device includes the phosphor wheel described above.

Abstract: A light conversion device includes a phosphor wheel, a circulation fan, a motor, a casing unit, and a heat absorber. The phosphor wheel has a first side on which a phosphor layer is formed. The circulation fan blows an air flow to the phosphor layer. The motor rotatably drives the phosphor wheel. The casing unit houses the phosphor wheel, the circulation fan, and the motor. In the casing unit, a circulation path of the air flow created by the circulation fan is formed. The heat absorber is in the shape of a cylinder. The heat absorber includes a fin structure including a plurality of fins arranged along a radial direction of the casing unit and provided so as to extend in a height direction of the cylinder. The air flow is supplied to the heat absorber to cool the air flow that has absorbed heat generated at the phosphor layer.

Abstract: An antibody has an antagonistic effect against IL-33. In particular an isolated human anti-IL-33 neutralizing monoclonal antibody has framework regions with amino acid sequences from a germline, including combinations and fragments of such sequences. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce the foregoing human anti-IL-33 neutralizing monoclonal antibodies having framework regions.

Abstract: A workpiece simulation part estimates the amount of movement of the workpiece from drive information and estimates the current position of the workpiece by adding the amount of movement to the previous position of the workpiece, the drive information being generated for, among at least one actuator, an actuator that is assumed to constrain the workpiece under the constraint conditions. A sensor simulation part uses the current position of the workpiece to generate sensor simulation information. An input/output switching part transmits the drive information to the workpiece simulation part and transmits the sensor simulation information as alternate information of the sensor information to the control-program execution part.

Abstract: The phosphor wheel in the present disclosure includes a disk-shaped member that is rotated about a rotation axis, and a phosphor layer disposed on one face of the disk-shaped member. The disk-shaped member has a hollow-box structure that forms an enclosed space. A coolant is sealed in the enclosed space. The coolant evaporates to a gas state from a liquid state at more than or equal to predetermined temperature. In the liquid state, a volume of the coolant is smaller than a capacity of the enclosed space. The present disclosure further provides a light conversion device including the phosphor wheel of the present disclosure.

Abstract: The phosphor wheel device includes a phosphor wheel, a circulation fan, a motor and a casing unit. The phosphor wheel is disc-shaped, and includes an annular phosphor layer formed on a first face and a plurality of openings disposed on an inner circumferential side. The circulation fan is mounted to a second face opposite to the first face, and blows air through the openings to the phosphor layer side. The motor drives and rotates the phosphor wheel and the circulation fan. The casing unit accommodates the phosphor wheel, the circulation fan, and the motor, and includes a circulation path formed for an airflow generated by the circulation fan to circulate. The casing unit includes an outer cylindrical portion and an inner cylindrical portion disposed substantially concentrically inside the outer cylindrical portion. Both ends of the outer cylindrical portion communicate with both ends of the inner cylindrical portion.

Abstract: A workpiece simulation part estimates the amount of movement of the workpiece from drive information and estimates the current position of the workpiece by adding the amount of movement to the previous position of the workpiece, the drive information being generated for, among at least one actuator, an actuator that is assumed to constrain the workpiece under the constraint conditions. A sensor simulation part uses the current position of the workpiece to generate sensor simulation information. An input/output switching part transmits the drive information to the workpiece simulation part and transmits the sensor simulation information as alternate information of the sensor information to the control-program execution part.

Abstract: A technique for enabling reduction in user operations. A program generating apparatus includes a control distribution unit and a communication function adding unit. The control distribution unit allocates respective control blocks of a control model to controllers, based on the control model received by a control model input unit, and setting information and connection information received by a setting information input unit. The communication function adding unit adds, when first and second ones of the control blocks are connected to each other, a communication control block to a connected part between the first and second control blocks, the first and second control blocks being allocated to different ones of the controllers in the allocated control model.

Abstract: A lens barrel: an optical system; a focusing manipulation unit capable of changing a focal position of the optical system in a normal photographing area and in a macro photographing area where the focal position can be changed for an object located at a position shorter than a shortest distance position of the normal photographing area; a photographing mode switching unit for switching between a normal photographing mode and a macro photographing mode; and an index ring having a normal scale and a macro scale, the normal scale indicating an object distance in the normal photographing mode, and the macro scale indicating the object distance in the macro photographing mode. Then, the photographing mode switching unit switches a display position of the index ring between the normal scale and the macro scale, and the focusing manipulation unit changes the focal position displayed on the index ring by rotation manipulation.

Abstract: The phosphor wheel device includes a phosphor wheel, a circulation fan, a motor and a casing unit. The phosphor wheel is disc-shaped, and includes an annular phosphor layer formed on a first face and a plurality of openings disposed on an inner circumferential side. The circulation fan is mounted to a second face opposite to the first face, and blows air through the openings to the phosphor layer side. The motor drives and rotates the phosphor wheel and the circulation fan. The casing unit accommodates the phosphor wheel, the circulation fan, and the motor, and includes a circulation path formed for an airflow generated by the circulation fan to circulate. The casing unit includes an outer cylindrical portion and an inner cylindrical portion disposed substantially concentrically inside the outer cylindrical portion. Both ends of the outer cylindrical portion communicate with both ends of the inner cylindrical portion.

Abstract: The periodic magnetic field generator includes a flat-shaped first yoke, and a plurality of main permanent magnets, an auxiliary permanent magnet, and a side permanent magnet on the first yoke. The plurality of main permanent magnets are magnetized in a first direction of generating magnetic fields, the direction being perpendicular to the first yoke, and disposed such that orientations of the magnetization become opposite alternately in the first direction. The auxiliary permanent magnet is magnetized in a second direction perpendicular to side faces of the plurality of main permanent magnets, and placed between the side faces of the main permanent magnets. The side permanent magnet is magnetized in a third direction perpendicular to the first direction, and disposed so as to cover end faces of the main permanent magnets and the auxiliary permanent magnet, the end faces being perpendicular to the side faces of the main permanent magnets.

Abstract: A light conversion device includes a phosphor wheel, a circulation fan, a motor, a casing unit, and a heat absorber. The phosphor wheel has a first side on which a phosphor layer is formed. The circulation fan blows an air flow to the phosphor layer. The motor rotatably drives the phosphor wheel. The casing unit houses the phosphor wheel, the circulation fan, and the motor. In the casing unit, a circulation path of the air flow created by the circulation fan is formed. The heat absorber is in the shape of a cylinder. The heat absorber includes a fin structure including a plurality of fins arranged along a radial direction of the casing unit and provided so as to extend in a height direction of the cylinder. The air flow is supplied to the heat absorber to cool the air flow that has absorbed heat generated at the phosphor layer.

Abstract: A technique for enabling reduction in user operations. A program generating apparatus includes a control distribution unit and a communication function adding unit. The control distribution unit allocates respective control blocks of a control model to controllers, based on the control model received by a control model input unit, and setting information and connection information received by a setting information input unit. The communication function adding unit adds, when first and second ones of the control blocks are connected to each other, a communication control block to a connected part between the first and second control blocks, the first and second control blocks being allocated to different ones of the controllers in the allocated control model.

Abstract: An antibody has an antagonistic effect against IL-33. In particular an isolated human anti-IL-33 neutralizing monoclonal antibody has framework regions with amino acid sequences from a germline, including combinations and fragments of such sequences. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce the foregoing human anti-IL-33 neutralizing monoclonal antibodies having framework regions.

Abstract: An object of the present invention is to provide an antibody having antagonistic effect against IL-33, in particular an isolated human anti-IL-33 neutralizing monoclonal antibody wherein amino acid sequences of framework regions are amino acid sequences that are amino acid sequences from a germline or a combination of amino acid sequences thereof, or a fragment thereof. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce a human anti-IL-33 neutralizing monoclonal antibody having framework regions comprising amino acid sequences that are amino acid sequences of a germline or a combination of amino acid sequences thereof.

Abstract: An object of the present invention is to provide an antibody having antagonistic effect against IL-33, in particular an isolated human anti-IL-33 neutralizing monoclonal antibody wherein amino acid sequences of framework regions are amino acid sequences that are amino acid sequences from a germline or a combination of amino acid sequences thereof, or a fragment thereof. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce a human anti-IL-33 neutralizing monoclonal antibody having framework regions comprising amino acid sequences that are amino acid sequences of a germline or a combination of amino acid sequences thereof.

Abstract: When change amount information calculated by a change amount information calculating unit satisfies a start condition and a signal condition is true for an operation instruction the start condition and the signal condition of which are defined, an operation instruction execution control unit determines a start of the corresponding operation instruction and determines operation completion based on a completion condition determined in advance of the operation instruction. An operation instruction executing unit executes the operation instruction the start of which is determined by the operation instruction execution control unit and stops the operation instruction when the operation completion is determined by the operation instruction execution control unit.