Patents by Inventor Tsuyoshi Fukuhara
Tsuyoshi Fukuhara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8093429Abstract: Provided are a fluorous-tag-introduced fluoroamine of a general formula (I), its production method, a method of fluorination of a substrate having functional group containing oxygen with the fluoroamine serving as a fluorinating agent, and a method of recovering a fluorous-tag-introduced amide after the fluorination. The fluoroamine and its production method, as well as the fluorination method with the fluoroamine and the method of recovery of a fluorous-tag-introduced amide are ecological and advantageous in industrial use, as the load for separating and collecting the product after the fluorination with the fluoroamine serving as a fluorinating agent is small. (In the formula, R0 is an alkyl group or an aryl group having substituent(s) of Rf—(CH2)m—; Rf is a perfluoroalkyl group; m is from 0 to 2; R1 and R2 each are an alkyl group or an aryl group.Type: GrantFiled: May 31, 2007Date of Patent: January 10, 2012Assignees: National University Corporation Hokkaido University, Mitsubishi Gas Chemical Company, Inc.Inventors: Toshio Hidaka, Takafumi Yoshimura, Shoji Hara, Tsuyoshi Fukuhara
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Patent number: 8063205Abstract: The present invention is a method for producing a 2-oxazoline analogue or a 1,3-oxazine analogue represented by the following general formula (3) by reacting a 1,2-aminoalcohol compound or a 1,2-aminothiol compound with an ?,?-dihaloamine compound. (In the formula, n represents 0 or 1, and R represents an oxygen atom or a sulfur atom. R1, R2 and R3 each represents an atom or a group shown in Group 1 to Group 3, and R0 represents an atom or a group shown in Group 2 or Group 3. Two or more of R1, R2 and R3 may be bonded to each other to form a ring.Type: GrantFiled: August 30, 2006Date of Patent: November 22, 2011Assignees: National University Corporation Hokkaido University, Mitsubishi Gas Chemical Company, Inc.Inventors: Shoji Hara, Tsuyoshi Fukuhara, Toshio Hidaka
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Patent number: 7968751Abstract: A method of fluorination comprising reacting monosaccharides, oligosaccharides, polysaccharides, composite saccharides formed by bonding of these saccharides with proteins and lipids and saccharides having polyalcohols, aldehydes, ketones and acids of the polyalcohols, and derivatives and condensates of these compounds with a fluorinating agent represented by general formula (I) thermally or under irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region. In accordance with the method, the fluorination at a selected position can be conducted safely at a temperature in the range of 150 to 200° C. where the reaction is difficult in accordance with conventional methods. The above method comprising the irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region can be applied to substrates other than saccharides.Type: GrantFiled: February 7, 2008Date of Patent: June 28, 2011Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Shoji Hara, Tsuyoshi Fukuhara
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Patent number: 7892518Abstract: A method of fluorination comprising reacting monosaccharides, oligosaccharides, polysaccharides, composite saccharides formed by bonding of these saccharides with proteins and lipids and saccharides having polyalcohols, aldehydes, ketones and acids of the polyalcohols, and derivatives and condensates of these compounds with a fluorinating agent represented by general formula (I) thermally or under irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region. In accordance with the method, the fluorination at a selected position can be conducted safely at a temperature in the range of 150 to 200° C. where the reaction is difficult in accordance with conventional methods. The above method comprising the irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region can be applied to substrates other than saccharides.Type: GrantFiled: February 7, 2008Date of Patent: February 22, 2011Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Shoji Hara, Tsuyoshi Fukuhara
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Patent number: 7829741Abstract: A process for producing an ?,?-difluoroamine which comprises using hydrogen fluoride and a Lewis base in specific amounts in the halogen-fluorine exchange reaction using an ?,?-dihaloamine as the substrate. The process can be industrially applied, enables to obtain the object compound in a short time at a great yield and can be conducted easily with excellent productivity.Type: GrantFiled: October 20, 2005Date of Patent: November 9, 2010Assignees: National University Corporation, Mitsubishi Gas Chemical Company, Inc.Inventors: Tsuyoshi Fukuhara, Shoji Hara, Toshio Hidaka
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Publication number: 20090281309Abstract: The present invention is a method for producing a 2-oxazoline analogue or a 1,3-oxazine analogue represented by the following general formula (3) by reacting a 1,2-aminoalcohol compound or a 1,2-aminothiol compound with an ?,?-dihaloamine compound. (In the formula, n represents 0 or 1, and R represents an oxygen atom or a sulfur atom. R1, R2 and R3 each represents an atom or a group shown in Group 1 to Group 3, and R0 represents an atom or a group shown in Group 2 or Group 3. Two or more of R1, R2 and R3 may be bonded to each other to form a ring.Type: ApplicationFiled: August 30, 2006Publication date: November 12, 2009Inventors: Shoji Hara, Tsuyoshi Fukuhara, Toshio Hidaka
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Publication number: 20090198086Abstract: Provided are a fluorous-tag-introduced fluoroamine of a general formula (I), its production method, a method of fluorination of a substrate having functional group containing oxygen with the fluoroamine serving as a fluorinating agent, and a method of recovering a fluorous-tag-introduced amide after the fluorination. The fluoroamine and its production method, as well as the fluorination method with the fluoroamine and the method of recovery of a fluorous-tag-introduced amide are ecological and advantageous in industrial use, as the load for separating and collecting the product after the fluorination with the fluoroamine serving as a fluorinating agent is small. (In the formula, R0 is an alkyl group or an aryl group having substituent(s) of Rf—(CH2)m—; Rf is a perfluoroalkyl group; m is from 0 to 2; R1 and R2 each are an alkyl group or an aryl group.Type: ApplicationFiled: May 31, 2007Publication date: August 6, 2009Inventors: Toshio Hidaka, Takafumi Yoshimura, Shoji Hara, Tsuyoshi Fukuhara
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Publication number: 20090177012Abstract: A process for producing an ?,?-difluoroamine which comprises using hydrogen fluoride and a Lewis base in specific amounts in the halogen-fluorine exchange reaction using an ?,?-dihaloamine as the substrate. The process can be industrially applied, enables to obtain the object compound in a short time at a great yield and can be conducted easily with excellent productivity.Type: ApplicationFiled: October 20, 2005Publication date: July 9, 2009Inventors: Tsuyoshi Fukuhara, Shoji Hara, Toshio Hidaka
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Publication number: 20080319228Abstract: A method of fluorination comprising reacting monosaccharides, oligosaccharides, polysaccharides, composite saccharides formed by bonding of these saccharides with proteins and lipids and saccharides having polyalcohols, aldehydes, ketones and acids of the polyalcohols, and derivatives and condensates of these compounds with a fluorinating agent represented by general formula (I) thermally or under irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region. In accordance with the method, the fluorination at a selected position can be conducted safely at a temperature in the range of 150 to 200° C. where the reaction is difficult in accordance with conventional methods. The above method comprising the irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region can be applied to substrates other than saccharides.Type: ApplicationFiled: February 7, 2008Publication date: December 25, 2008Inventors: Shoji Hara, Tsuyoshi Fukuhara
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Publication number: 20080154064Abstract: A method of fluorination comprising reacting monosaccharides, oligosaccharides, polysaccharides, composite saccharides formed by bonding of these saccharides with proteins and lipids and saccharides having polyalcohols, aldehydes, ketones and acids of the polyalcohols, and derivatives and condensates of these compounds with a fluorinating agent represented by general formula (I) thermally or under irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region. In accordance with the method, the fluorination at a selected position can be conducted safely at a temperature in the range of 150 to 200° C. where the reaction is difficult in accordance with conventional methods. The above method comprising the irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region can be applied to substrates other than saccharides.Type: ApplicationFiled: February 7, 2008Publication date: June 26, 2008Inventors: Shoji Hara, Tsuyoshi Fukuhara
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Patent number: 7351863Abstract: A method of fluorination comprising reacting monosaccharides, oligosaccharides, polysaccharides, composite saccharides formed by bonding of these saccharides with proteins and lipids and saccharides having polyalcohols, aldehydes, ketones and acids of the polyalcohols, and derivatives and condensates of these compounds with a fluorinating agent represented by general formula (I) thermally or under irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region. In accordance with the method, the fluorination at a selected position can be conducted safely at a temperature in the range of 150 to 200° C. where the reaction is difficult in accordance with conventional methods.Type: GrantFiled: December 1, 2003Date of Patent: April 1, 2008Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Shoji Hara, Tsuyoshi Fukuhara
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Patent number: 7311890Abstract: A process for the production of a fluorinated organic compound, characterized by fluorinating an organic compound having a hydrogen atoms using IF5; and a novel fluorination process for fluorinating an organic compound having a hydrogen atoms by using a fluorinating agent containing IF5 and at least one member selected from the group consisting of acids, bases, salts and additives.Type: GrantFiled: July 7, 2004Date of Patent: December 25, 2007Assignee: Daikin Industries, Ltd.Inventors: Norihiko Yoneda, Tsuyoshi Fukuhara, Kazuhiro Shimokawa, Kenji Adachi, Satoshi Oishi
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Patent number: 7307185Abstract: The present invention provides a process for producing an optically active fluoro compound represented by formula (3) through reaction between a specific fluoroamine and an optically active diol; and a process for producing an optically active fluoroalcohol through hydrolysis of the optically active fluoro compound. According to the process of the present invention, such optically active fluoro compounds and optically active fluoroalcohols can be produced at high optical purity and high yield in a simple manner.Type: GrantFiled: March 2, 2005Date of Patent: December 11, 2007Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Shoji Hara, Tsuyoshi Fukuhara
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Publication number: 20070191631Abstract: The present invention provides a process for producing an optically active fluoro compound represented by formula (3) through reaction between a specific fluoroamine and an optically active diol; and a process for producing an optically active fluoroalcohol through hydrolysis of the optically active fluoro compound. According to the process of the present invention, such optically active fluoro compounds and optically active fluoroalcohols can be produced at high optical purity and high yield in a simple manner. Such optically active fluoroalcohols are a useful source for producing drugs, pesticides, and other functional chemicals.Type: ApplicationFiled: March 2, 2005Publication date: August 16, 2007Inventors: Shoji Hara, Tsuyoshi Fukuhara
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Publication number: 20060014972Abstract: A method of fluorination comprising reacting monosaccharides, oligosaccharides, polysaccharides, composite saccharides formed by bonding of these saccharides with proteins and lipids and saccharides having polyalcohols, aldehydes, ketones and acids of the polyalcohols, and derivatives and condensates of these compounds with a fluorinating agent represented by general formula (I) thermally or under irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region. In accordance with the method, the fluorination at a selected position can be conducted safely at a temperature in the range of 150 to 200° C. where the reaction is difficult in accordance with conventional methods. The above method comprising the irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region can be applied to substrates other than saccharides.Type: ApplicationFiled: December 1, 2003Publication date: January 19, 2006Inventors: Shoji Hara, Tsuyoshi Fukuhara
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Publication number: 20040245505Abstract: A process for the production of a fluorinated organic compound, characterized by fluorinating an organic compound having a hydrogen atoms using IF5; and a novel fluorination process for fluorinating an organic compound having a hydrogen atoms by using a fluorinating agent containing IF5 and at least one member selected from the group consisting of acids, bases, salts and additives.Type: ApplicationFiled: July 7, 2004Publication date: December 9, 2004Applicant: Daikin Industries, Ltd.Inventors: Norihiko Yoneda, Tsuyoshi Fukuhara, Kazuhiro Shimokawa, Kenji Adachi, Satoshi Oishi
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Patent number: 6784327Abstract: A process for the production of a fluorinated organic compound, characterized by fluorinating an organic compound having a hydrogen atoms using IF5; and a novel fluorination process for fluorinating an organic compound having a hydrogen atoms by using a fluorinating agent containing IF5 and at least one member selected from the group consisting of acids, bases, salts and additives.Type: GrantFiled: December 10, 2002Date of Patent: August 31, 2004Assignee: Daikin Industries, Ltd.Inventors: Norihiko Yoneda, Tsuyoshi Fukuhara, Kazuhiro Shimokawa, Kenji Adachi, Satoshi Oishi
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Patent number: 6666748Abstract: The invention provides a machining center for machining a workpiece by moving a grinding wheel and the workpiece relative to each other in the X, Y and Z directions. The machining center has a main spindle for removably mounting a grinding wheel, a spindle head for rotationally supporting the main spindle, a table for mounting the workpiece, a column for movably supporting the spindle head, and tool dressing means having a dresser spindle, provided over the spindle head to move in the vertical direction toward and away from the grinding wheel mounted to the main spindle, for mounting a dresser for truing or dressing the outer peripheral surface of the grinding wheel.Type: GrantFiled: September 4, 2001Date of Patent: December 23, 2003Assignee: Makino Milling Machine Co., LTDInventors: Kazuyuki Hiramoto, Naoshi Takayama, Keigo Tada, Takashi Hoshi, Naozumi Tanikawa, Tsuyoshi Fukuhara, Kazutoyo Moriguchi
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Publication number: 20030176747Abstract: A process for the production of a fluorinated organic compound, characterized by fluorinating an organic compound having a hydrogen atoms using IF5; and a novel fluorination process for fluorinating an organic compound having a hydrogen atoms by using a fluorinating agent containing IF5 and at least one member selected from the group consisting of acids, bases, salts and additives.Type: ApplicationFiled: December 10, 2002Publication date: September 18, 2003Inventors: Norihiko Yoneda, Tsuyoshi Fukuhara, Kazuhiro Shimokawa, Kenji Adachi, Satoshi Oishi
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Publication number: 20020028628Abstract: The invention provides a machining center for machining a workpiece by moving a grinding wheel and the workpiece relative to each other in the X, Y and Z directions. The machining center has a main spindle for removably mounting a grinding wheel, a spindle head for rotationally supporting the main spindle, a table for mounting the workpiece, a column for movably supporting the spindle head, and tool dressing means having a dresser spindle, provided over the spindle head to move in the vertical direction toward and away from the grinding wheel mounted to the main spindle, for mounting a dresser for truing or dressing the outer peripheral surface of the grinding wheel.Type: ApplicationFiled: September 4, 2001Publication date: March 7, 2002Inventors: Kazuyuki Hiramoto, Naoshi Takayama, Keigo Tada, Takashi Hoshi, Naozumi Tanikawa, Tsuyoshi Fukuhara, Kazutoyo Moriguchi