Patents by Inventor Tsuyoshi Fukui

Tsuyoshi Fukui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11319617
    Abstract: The present invention provides a method for producing a ring-rolled material of an Fe—Ni based superalloy which inhibits AGG, has a fine-grained structure having an ASTM grain size number of at least 8, and has high circularity. A method for producing a ring-rolled material of an Fe—Ni based superalloy having a composition of an Alloy 718 comprises: heating a ring-shaped material for ring rolling having the composition, in a temperature range of 900° C. to 980° C., and performing finishing ring rolling, as a finishing ring rolling step; heating the ring-rolled material that has been subjected to the finishing ring rolling, in a temperature range of 980 to 1010° C.; and correcting ellipticalness while expanding a diameter of the ring-rolled material by using a ring expander.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: May 3, 2022
    Assignee: HITACHI METALS, LTD.
    Inventors: Chuya Aoki, Tsuyoshi Fukui, Daigo Ohtoyo, Etsuo Fujita, Naoyuki Iwasa, Taku Hirosawa
  • Publication number: 20220042144
    Abstract: The present invention provides a method for producing a ring-rolled material of an Fe—Ni based superalloy which inhibits AGG, has a fine-grained structure having an ASTM grain size number of at least 8, and has high circularity. A method for producing a ring-rolled material of an Fe—Ni based superalloy having a composition of an Alloy 718 comprises: heating a ring-shaped material for ring rolling having the composition, in a temperature range of 900° C. to 980° C., and performing finishing ring rolling, as a finishing ring rolling step; heating the ring-rolled material that has been subjected to the finishing ring rolling, in a temperature range of 980 to 1010° C.; and correcting ellipticalness while expanding a diameter of the ring-rolled material by using a ring expander.
    Type: Application
    Filed: September 19, 2019
    Publication date: February 10, 2022
    Inventors: Chuya AOKI, Tsuyoshi FUKUI, Daigo OHTOYO, Etsuo FUJITA, Naoyuki IWASA, Taku HIROSAWA
  • Publication number: 20220032359
    Abstract: A method for producing a ring-rolled material of an Fe—Ni based superalloy, which has a high circularity, can inhibit AGG, and can inhibit grain growth. A method for producing a ring-rolled material of an Fe—Ni based superalloy having a composition of an Alloy 718 comprises: a finishing ring rolling step of heating a ring-shaped material for ring rolling having the composition, in a temperature range of 900° C. to 980° C., and performing finishing ring rolling; and a circularity correcting step of correcting an ellipticalness of the ring-rolled material that has been rolled in the finishing ring rolling step, while expanding a diameter of the ring-rolled material by using a ring expander including a pipe-expanding cone and a pipe-expanding die, wherein the ring-rolled material that has been rolled in the finishing ring rolling step is subjected to circularity correction without being reheated or after having been heated to up to 960° C.
    Type: Application
    Filed: September 19, 2019
    Publication date: February 3, 2022
    Inventors: Chuya AOKI, Tsuyoshi FUKUI, Daigo OHTOYO, Etsuo FUJITA, Naoyuki IWASA, Taku HIROSAWA
  • Patent number: 10604779
    Abstract: Disclosed is a highly efficient method for production of highly pure mutant-type human erythropoietin. The method is for production of mutant-type human erythropoietin, in which a transformed mammalian cell is allowed to produce the mutant-type human erythropoietin, and the supernatant of the culture is subjected to hydrophobic column chromatography, multimodal anion exchange column chromatography, anion exchange column chromatography, phosphate group affinity column chromatography, and gel filtration column chromatography, in this order.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: March 31, 2020
    Assignee: JCR PHARMACEUTICALS CO., LTD.
    Inventors: Shinji Kakimoto, Miroslav Matev, Tsuyoshi Fukui, Yukichi Hatano, Junya Tani, Kazutoshi Mihara, Kenichi Takahashi, Atsushi Sugimura
  • Patent number: 10576531
    Abstract: A cycle is repeated a plurality of times, which includes a forging process for placing a material to be forged in a lower die and pressing the material to be forged in this state and then separating an upper die from the material to be forged; an elevation process for lifting the material to be forged by using an elevation device to separate the material to be forged from the lower die; a rotation process for rotating the material to be forged around its center by using a rotation device; and a lowering process for placing the material to be forged rotated by the elevation device in the lower die.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: March 3, 2020
    Assignee: Hitachi Metals, LTD.
    Inventors: Eiji Shimohira, Koji Sato, Tsuyoshi Fukui
  • Patent number: 10527283
    Abstract: Provided is a burner tile that has good fire resistance, good heat resistance, good erosion resistance, and good thermal shock resistance. A burner tile 1E includes a molded inorganic fiber product and has a burner main hole 3E. The burner tile 1E includes an inner layer 120 including a combination of inorganic fiber rods 121 and 122 such that the inner layer 120 defines an inner circumferential surface of the main hole 3E, and an outer layer 130 formed by surrounding an outer circumferential surface of the inner layer 120 with the molded inorganic fiber product. Part of the burner tile 1E extending along the inner circumferential surface of the main hole 3E has a high bulk density achieved by highly concentrating an inorganic binder in the inorganic fiber in part including the inner circumferential surface.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: January 7, 2020
    Assignees: MITSUBISHI CHEMICAL CORPORATION, CHUGAI RO CO., LTD.
    Inventors: Tsuyoshi Fukui, Mitsuo Suzuki, Shunsuke Yamamoto, Takeshi Oohashi, Kensuke Kawabata
  • Patent number: 10385325
    Abstract: Disclosed is a method for production of recombinant human alpha-galactosidase A (rh alpha-Gal A) in a large scale, with a high purity. The method comprises the steps of (a) culturing rh alpha-Gal A-producing mammalian cells in a serum-free medium, (b) collecting culture supernatant, (c) subjecting the culture supernatant to anion-exchange column chromatography, (d) to hydrophobic column chromatography, (e) to a column chromatography employing as solid phase a material having affinity for phosphate group, (f) to cation-exchange column chromatography, (g) to dye-affinity column chromatography, and (h) to gel filtration column chromatography, in the order.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: August 20, 2019
    Assignee: JCR PHARMACEUTICALS CO., LTD.
    Inventors: Tsuyoshi Fukui, Atsuko Kawasaki, Yukichi Hatano, Yae Ito, Kazutoshi Mihara, Atsushi Sugimura
  • Publication number: 20190225700
    Abstract: Disclosed is a method for production of a fusion protein in which an antibody and a lysosomal enzyme are fused. The method comprises; (a) a step of culturing mammalian cells producing the fusion protein in a serum-free medium to let the mammalian cells secrete the fusion protein in the culture medium, (b) a step of collecting culture supernatant by removing the mammalian cells from the culture medium, and (c) a step of purifying the fusion protein from the culture supernatant by using a column chromatography employing as a solid phase a material to which a substance having affinity for the fusion protein has been bound, a column chromatography employing as a solid phase a material having affinity for the phosphate group, and a size exclusion column chromatography.
    Type: Application
    Filed: August 25, 2017
    Publication date: July 25, 2019
    Applicant: JCR Pharmaceuticals Co., Ltd.
    Inventors: Yuri Koshimura, Hiroyuki Sonoda, Miroslav Matev, Shinji Kakimoto, Tsuyoshi Fukui, Yukichi Hatano
  • Patent number: 10286443
    Abstract: A ring rolling mill includes: a rotary drive main roll and a mandrel roll, which are for reducing the thickness of and rolling a ring-shaped material from the radial direction; a pair of rotary drive axial rolls for reducing the thickness of and rolling the ring-shaped material from the axial direction; a measuring roll for measuring the diameter of the ring-shaped material during rolling; and a speed control unit for controlling the speed of the axial rolls. The speed control unit is configured to repeat measuring the diameter at predetermined time intervals ?t and comparing a measurement value Lt of the diameter at time t and a measurement value Lt+?t of the diameter at time t+?t, and the speed control unit is further configured to maintain the speed of the axial rolls unchanged upon the result of the comparison being Lt+?t<Lt.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: May 14, 2019
    Assignee: HITACHI METALS, LTD.
    Inventors: Naoyuki Iwasa, Tsuyoshi Fukui
  • Publication number: 20190078129
    Abstract: Disclosed is a highly efficient method for production of highly pure mutant-type human erythropoietin. The method is for production of mutant-type human erythropoietin, in which a transformed mammalian cell is allowed to produce the mutant-type human erythropoietin, and the supernatant of the culture is subjected to hydrophobic column chromatography, multimodal anion exchange column chromatography, anion exchange column chromatography, phosphate group affinity column chromatography, and gel filtration column chromatography, in this order.
    Type: Application
    Filed: March 7, 2017
    Publication date: March 14, 2019
    Inventors: Shinji KAKIMOTO, Miroslav MATEV, Tsuyoshi FUKUI, Yukichi HATANO, Junya TANI, Kazutoshi MIHARA, Kenichi TAKAHASHI, Atsushi SUGIMURA
  • Patent number: 10094238
    Abstract: The present invention provides a high quality material for ring rolling. The material includes radially outer and inner peripheral surfaces. In the material, a center of gravity on a half section is located so as to be closer to the outer peripheral surface in contact with a main roll than a center of the half section in a thickness direction, a shape of the half section includes a height reducing portion having a height from a center line dividing the half section into halves in a height direction, this height is gradually reduced toward the inner peripheral surface in contact with a mandrel roll, and the shape is formed in a substantially linear symmetry such that the center line is a symmetric axis. A height of the inner peripheral surface is from 20% to 50% of a maximum height of the material.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: October 9, 2018
    Assignee: Hitachi Metals, Ltd.
    Inventors: Tetsuya Yagami, Toshiya Teramae, Etsuo Fujita, Shinya Nagao, Remi Mukouse, Naoyuki Iwasa, Tsuyoshi Fukui, Chuya Aoki
  • Publication number: 20180016564
    Abstract: Disclosed is a method for production of recombinant human alpha-galactosidase A (rh alpha-Gal A) in a large scale, with a high purity. The method comprises the steps of (a) culturing rh alpha-Gal A-producing mammalian cells in a serum-free medium, (b) collecting culture supernatant, (c) subjecting the culture supernatant to anion-exchange column chromatography, (d) to hydrophobic column chromatography, (e) to a column chromatography employing as solid phase a material having affinity for phosphate group, (f) to cation-exchange column chromatography, (g) to dye-affinity column chromatography, and (h) to gel filtration column chromatography, in the order.
    Type: Application
    Filed: January 21, 2016
    Publication date: January 18, 2018
    Inventors: Tsuyoshi FUKUI, Atsuko KAWASAKI, Yukichi HATANO, Yae ITO, Kazutoshi MIHARA, Atsushi SUGIMURA
  • Patent number: 9751281
    Abstract: The inorganic fiber molded body of the present invention is characterized in that the molded body has an extremely light weight, and is free from problems such as scattering of fibers and particulate matters from a surface thereof and environmental pollution such as generation of harmful gases. In addition, the present invention provides an inorganic fiber molded body that is excellent in not only thermal shock resistance and mechanical shock resistance but also a high-speed wind erosion resistance, well-balanced in properties and can be used in the applications of various heat-insulating materials. The present invention relates to an inorganic fiber molded body comprising inorganic fibers and inorganic binder particles and having at least one set of a high-fiber density region and a low-fiber density region, in which a ratio of a content of the binder particles in the high-fiber density region to a content of the binder particles in the low-fiber density region as measured by a predetermined method is 0.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: September 5, 2017
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Tsuyoshi Fukui, Toshio Ito, Yusaku Hata, Hisashi Aoyagi, Hidetaka Ito
  • Patent number: 9719369
    Abstract: A manufacturing method provides a high-quality material for ring rolling. The manufacturing method of the material for ring rolling includes a step of heating a disk-shaped material for hot forging to a hot working temperature, a step of arranging the material for hot forging onto a lower die having a convex portion with a truncated conical shape, a step of forming a thin portion by pressing a center portion of the material for hot forging by using an upper die having a convex portion with a truncated conical shape, and a step of manufacturing a material for ring rolling by removing the thin portion wherein a center of gravity on a half section of the material for ring rolling is located so as to be closer to an outer peripheral surface of the half section than a center of the half section in a thickness direction of the half section.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: August 1, 2017
    Assignee: HITACHI METALS, LTD.
    Inventors: Tetsuya Yagami, Toshiya Teramae, Etsuo Fujita, Shinya Nagao, Remi Mukouse, Naoyuki Iwasa, Tsuyoshi Fukui, Chuya Aoki
  • Publication number: 20170100769
    Abstract: A cycle is repeated a plurality of times, which includes a forging process for placing a material to be forged in a lower die and pressing the material to be forged in this state and then separating an upper die from the material to be forged; an elevation process for lifting the material to be forged by using an elevation device to separate the material to be forged from the lower die; a rotation process for rotating the material to be forged around its center by using a rotation device; and a lowering process for placing the material to be forged rotated by the elevation device in the lower die.
    Type: Application
    Filed: October 5, 2016
    Publication date: April 13, 2017
    Inventors: Eiji SHIMOHIRA, Koji SATO, Tsuyoshi FUKUI
  • Patent number: 9617529
    Abstract: Disclosed is a method for production of recombinant human alpha-galactosidase A (rh alpha-Gal A) in a large scale, with a high purity. The method comprises the steps of (a) culturing rh alpha-Gal A-producing mammalian cells in a serum-free medium, (b) collecting culture supernatant, (c) subjecting the culture supernatant to anion-exchange column chromatography, (d) to hydrophobic column chromatography, (e) to a column chromatography employing as solid phase a material having affinity for phosphate group, (f) to cation-exchange column chromatography, and (g) to gel filtration column chromatography, in the order.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: April 11, 2017
    Assignee: JCR PHARMACEUTICALS CO., LTD.
    Inventors: Masahiro Asano, Toshihiro Yagi, Tsuyoshi Fukui, Atsuko Kawasaki, Yukichi Hatano, Kazutoshi Mihara, Atsushi Sugimura
  • Publication number: 20160348905
    Abstract: Provided is a burner tile that has good fire resistance, good heat resistance, good erosion resistance, and good thermal shock resistance. A burner tile 1E includes a molded inorganic fiber product and has a burner main hole 3E. The burner tile 1E includes an inner layer 120 including a combination of inorganic fiber rods 121 and 122 such that the inner layer 120 defines an inner circumferential surface of the main hole 3E, and an outer layer 130 formed by surrounding an outer circumferential surface of the inner layer 120 with the molded inorganic fiber product. Part of the burner tile 1E extending along the inner circumferential surface of the main hole 3E has a high bulk density achieved by highly concentrating an inorganic binder in the inorganic fiber in part including the inner circumferential surface.
    Type: Application
    Filed: January 29, 2015
    Publication date: December 1, 2016
    Applicants: MITSUBISHI PLASTICS, INC., CHUGAI RO CO., LTD.
    Inventors: Tsuyoshi FUKUI, Mitsuo SUZUKI, Shunsuke YAMAMOTO, Takeshi OOHASHI, Kensuke KAWABATA
  • Publication number: 20160288196
    Abstract: A ring rolling mill includes: a rotary drive main roll and a mandrel roll, which are for reducing the thickness of and rolling a ring-shaped material from the radial direction; a pair of rotary drive axial rolls for reducing the thickness of and rolling the ring-shaped material from the axial direction; a measuring roll for measuring the diameter of the ring-shaped material during rolling; and a speed control unit for controlling the speed of the axial rolls. The speed control unit is configured to repeat measuring the diameter at predetermined time intervals ?t and comparing a measurement value Lt of the diameter at time t and a measurement value Lt+?t of the diameter at time t+?t, and the speed control unit is further configured to maintain the speed of the axial rolls unchanged upon the result of the comparison being Lt+?t<Lt.
    Type: Application
    Filed: March 29, 2016
    Publication date: October 6, 2016
    Inventors: Naoyuki IWASA, Tsuyoshi FUKUI
  • Publication number: 20160281530
    Abstract: The present invention provides a high quality material for ring rolling. The material includes radially outer and inner peripheral surfaces. In the material, a center of gravity on a half section is located so as to be closer to the outer peripheral surface in contact with a main roll than a center of the half section in a thickness direction, a shape of the half section includes a height reducing portion having a height from a center line dividing the half section into halves in a height direction, this height is gradually reduced toward the inner peripheral surface in contact with a mandrel roll, and the shape is formed in a substantially linear symmetry such that the center line is a symmetric axis. A height of the inner peripheral surface is from 20% to 50% of a maximum height of the material.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 29, 2016
    Inventors: Tetsuya Yagami, Toshiya Teramae, Etsuo Fujita, Shinya Nagao, Remi Mukouse, Naoyuki Iwasa, Tsuyoshi Fukui, Chuya Aoki
  • Publication number: 20160271681
    Abstract: A manufacturing method provides a high-quality material for ring rolling. The manufacturing method of the material for ring rolling includes a step of heating a disk-shaped material for hot forging to a hot working temperature, a step of arranging the material for hot forging onto a lower die having a convex portion with a truncated conical shape, a step of forming a thin portion by pressing a center portion of the material for hot forging by using an upper die having a convex portion with a truncated conical shape, and a step of manufacturing a material for ring rolling by removing the thin portion wherein a center of gravity on a half section of the material for ring rolling is located so as to be closer to an outer peripheral surface of the half section than a center of the half section in a thickness direction of the half section.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 22, 2016
    Inventors: Tetsuya Yagami, Toshiya Teramae, Etsuo Fujita, Shinya Nagao, Remi Mukouse, Naoyuki Iwasa, Tsuyoshi Fukui, Chuya Aoki