Patents by Inventor Tsuyoshi Hirata
Tsuyoshi Hirata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230226205Abstract: It is an object of the present invention to provide an antibody binding to CDH6 and having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like. The present invention provides an anti-CDH6 antibody having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.Type: ApplicationFiled: July 26, 2022Publication date: July 20, 2023Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Atsuko SAITO, Tsuyoshi HIRATA, Kensuke NAKAMURA
-
Patent number: 11446386Abstract: It is an object of the present invention to provide an antibody binding to CDH6 and having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like. The present invention provides an anti-CDH6 antibody having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.Type: GrantFiled: May 14, 2018Date of Patent: September 20, 2022Assignee: DAIICHI SANKYO COMPANY, LIMITEDInventors: Atsuko Saito, Tsuyoshi Hirata, Kensuke Nakamura
-
Patent number: 11077202Abstract: It is an object of the present invention to provide an antibody binding to CDH6 and having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like. The present invention provides an anti-CDH6 antibody having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.Type: GrantFiled: September 2, 2020Date of Patent: August 3, 2021Assignee: DAIICHI SANKYO COMPANY, LIMITEDInventors: Atsuko Saito, Tsuyoshi Hirata, Kensuke Nakamura
-
Publication number: 20200390900Abstract: It is an object of the present invention to provide an antibody binding to CDH6 and having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like. The present invention provides an anti-CDH6 antibody having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.Type: ApplicationFiled: September 2, 2020Publication date: December 17, 2020Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Atsuko SAITO, Tsuyoshi HIRATA, JP NAKAMURA
-
Publication number: 20200171163Abstract: It is an object of the present invention to provide an antibody binding to CDH6 and having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like. The present invention provides an anti-CDH6 antibody having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.Type: ApplicationFiled: May 14, 2018Publication date: June 4, 2020Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Atsuko SAITO, Tsuyoshi HIRATA, Kensuke NAKAMURA
-
Patent number: 9328022Abstract: A copolymer that has sufficient dispersibility to various kinds of cements, including those having low fluidity (difficult cement). The copolymer is obtained by polymerizing monomer components including an unsaturated (poly)alkylene glycol ether monomer (a), an unsaturated carboxylic acid monomer (b), and an unsaturated cross-linkable monomer (c) or an unsaturated cross-linkable monomer (d). The unsaturated cross-linkable monomer (c) is allyl itaconate or allyl citraconate, or ester thereof. The unsaturated cross-linkable monomer (d) is an ester obtained by reaction of at least one acid, selected from the group consisting of (meth)acrylic acid, maleic acid, fumaric acid, itaconic acid, and citraconic acid and ester derived from the acids, with a (poly)alkylene glycol or a (poly)alkylene glycol ether.Type: GrantFiled: March 28, 2013Date of Patent: May 3, 2016Assignees: Nippon Shokubai Co., Ltd., Technische Universitat MunchenInventors: Tsuyoshi Hirata, Alex Lange, Johann Plank
-
Publication number: 20150065615Abstract: An object of the present invention is to provide a novel copolymer capable of exerting excellent dispersibility to various kinds of cement including cement having low fluidity (difficult cement), and a dispersant for cement and cement composition including the copolymer. The copolymer of the present invention is a copolymer obtainable by polymerizing monomer components including an unsaturated (poly)alkylene glycol ether monomer (a), an unsaturated carboxylic acid monomer (b), and an unsaturated cross-linkable monomer (c) or an unsaturated polymerizable monomer (d).Type: ApplicationFiled: March 28, 2013Publication date: March 5, 2015Inventors: Tsuyoshi Hirata, Alex Lange, Johann Plank
-
Patent number: 8076396Abstract: To provide an ultrarapid hardening cement composition with high strength, the composition having: excellent fluidity; excellent usable time; and excellent initial strength under low temperature atmosphere as well as under general temperature atmosphere, and improving strength and durability of a hardening product of the composition. An ultrarapid cement hardening composition comprising: an ultrarapid hardening cement (A) comprising a calcium aluminate; and a cement dispersant (B), wherein the cement dispersant (B) comprises a copolymer having: a repeating unit derived from a monomer represented by the following formula (1) and formula (2) as defined in the specification.Type: GrantFiled: August 30, 2006Date of Patent: December 13, 2011Assignees: Sumitomo Osaka Cement Co., Ltd, Nippon Shokubai Co., LtdInventors: Akira Ono, Hisashi Inokawa, Tsuyoshi Hirata, Hirokatsu Kawakami, Masami Hattori
-
Patent number: 7691982Abstract: The dispersant of the present invention comprises at least one component unit derived from kraft lignin and/or its salt and at least one component unit derived from at least one water-soluble monomer. The novel lignin derivative of the present invention comprises at least one component unit derived from kraft lignin and/or its salt, at least one polyoxyalkylene chain, and at least one anionic functional group.Type: GrantFiled: September 22, 2005Date of Patent: April 6, 2010Assignee: Nippon Shokubai Co., Ltd.Inventors: Takashi Tomita, Tsuyoshi Hirata
-
Patent number: 7662884Abstract: It is an object of the present invention, which has been made in view of the above-mentioned state of the art, to provide a cement admixture capable of improving the water-reducing ability of cement compositions and the like and enhancing the strength and durability of hardened products produced therefrom and further capable of adjusting the viscosity of such compositions so as to facilitate the works at the sites of handling the same, as well as a method of producing such cement additive. A cement admixture comprising a polycarboxylic acid polymer and a nitrogen atom-containing compound having non-amide bond, wherein the mass ratio (A/B) between the mass (A) of said polycarboxylic acid polymer and the mass (B) of said nitrogen atom-containing compound having non-amide bond satisfies the relation 200>(A/B)>1.Type: GrantFiled: April 23, 2003Date of Patent: February 16, 2010Assignee: Nippon Shokubai Co., Ltd.Inventors: Tsutomu Yuasa, Hiromichi Tanaka, Noboru Sakamoto, Tomotaka Nishikawa, Hiroko Izukashi, Toru Uno, Tsuyoshi Hirata, Tomiyasu Ueta, Yoshiyuki Onda
-
Publication number: 20090131560Abstract: To provide an ultrarapid hardening cement composition with high strength, the composition having: excellent fluidity; excellent usable time; and excellent initial strength under low temperature atmosphere as well as under general temperature atmosphere, and improving strength and durability of a hardening product of the composition.Type: ApplicationFiled: August 30, 2006Publication date: May 21, 2009Applicants: SUMITOMO OSAKA CEMENT CO. LTD, NIPPON SHOKUBAI CO. LTDInventors: Akira Ono, Hisashi Inokawa, Tsuyoshi Hirata, Hirokatsu Kawakami, Masami Hattori
-
Publication number: 20090054557Abstract: The present invention aims at providing a cement admixture having superior water-reducing performance, along with no decrease in slump and slump flow caused by decrease in fluidity of a cement composition over time.Type: ApplicationFiled: March 29, 2006Publication date: February 26, 2009Inventors: Hiroshi Yamazaki, Tsuyoshi Hirata, Akihiko Yamashita
-
Patent number: 7405264Abstract: It is an object of the present invention to provide a polycarboxylic acid polpolymer which improves the water reducing capacity and workability of cement compositions and the like and making them easier to handle when the fluidity and water reducing capacity are at the same levels, a method of producing the copolymer, and a cement additive and a cement composition comprising the copolymer. The present invention is further to provide a polycarboxylic acid copolymer and a cement additive which are capable of improving the strength and durability of hardening products of cement compositions, hence can advantageously be used in ultrahigh strength concrete. The present invention is polycarboxylic acid copolymers having high water reducing capacity, reducing the viscosity of cement compositions and improving the workability in applying cement.Type: GrantFiled: August 19, 2004Date of Patent: July 29, 2008Assignee: Nippon Shokubai Co., Ltd.Inventors: Tsutomu Yuasa, Tomotaka Nishikawa, Noboru Sakamoto, Tsuyoshi Hirata, Hiroko Izukashi, Tomiyasu Ueta, Hiromichi Tanaka, Yoshiyuki Onda, Toru Uno
-
Patent number: 7402644Abstract: The present invention provides: a production process for an alkylene oxide addition product, by which a high-molecular alkylene oxide addition product can be obtained with ordinary production facilities while the formation of by-products is suppressed; and production processes for derivatives from the alkylene oxide addition product.Type: GrantFiled: May 2, 2003Date of Patent: July 22, 2008Assignee: Nippon Shikubai Co., Ltd.Inventors: Toru Inaoka, Yoshiyuki Onda, Hiromichi Tanaka, Tsuyoshi Hirata
-
Patent number: 7321006Abstract: There are provided an admixture for cement which enhances water reducing property and flowability of a cement composition, and is excellent in slump retaining performance to retain the flowability with time, a polycarboxylic acid-based polymer for an admixture for cement suitable therefor, a producing method thereof, and a cement composition. One admixture for cement of the present invention contains copolymers (A) and (B) as an essential component, weight average molecular weights (AMw and BMw) of copolymers (A) and (B) are AMw>BMw, or peaktop molecular weights (AMp and BMp) of copolymers (A) and (B) are AMp>BMp. Another admixture for cement of the present invention contains a polycarboxylic acid-based polymer having a lower molecular weight side area ratio P of 50 to 87%.Type: GrantFiled: December 31, 2004Date of Patent: January 22, 2008Assignee: Nippon Shokubai Co., Ltd.Inventors: Toshio Hayashiya, Tomiyasu Ueta, Tsutomu Yuasa, Tsuyoshi Hirata, Hiroshi Yamazaki
-
Patent number: 7304104Abstract: The cement admixture of the present invention can provide viscosity decreasing ability as well as a high dispersing ability and slump loss preventing ability even in a high water reducing ratio range. The above-mentioned cement admixture comprises three components of a copolymer (A) containing a constituent unit (I) derived from the unsaturated (poly)alkylene glycol ether monomer (a) and a constituent unit (II) derived from a maleic acid monomer (b), a specific unsaturated (poly)alkylene glycol ether monomer (a) and a non-polymerizable (poly)alkylene glycol (B) having no alkenyl group.Type: GrantFiled: March 4, 2004Date of Patent: December 4, 2007Assignee: Nippon Shokubai Co. Ltd.Inventors: Akihiko Yamashita, Hiromichi Tanaka, Toru Uno, Yoshiyuki Onda, Tsuyoshi Hirata
-
Publication number: 20070260046Abstract: The dispersant of the present invention comprises at least one component unit derived from kraft lignin and/or its salt and at least one component unit derived from at least one water-soluble monomer. The novel lignin derivative of the present invention comprises at least one component unit derived from kraft lignin and/or its salt, at least one polyoxyalkylene chain, and at least one anionic functional group.Type: ApplicationFiled: September 22, 2005Publication date: November 8, 2007Inventors: Takashi Tomita, Tsuyoshi Hirata
-
Publication number: 20070254976Abstract: The efficiency of production of the polycarboxylic acid type cement dispersant is exalted. Photo-polymerization is adopted in the production of the polycarboxylic acid type cement dispersant by polymerizing at least one kind of monomer represented by the chemical formula 1 and at least one kind of monomer represented by the chemical formula 2. A polymer composition having a small solvent content is obtained by causing the polymerization reaction to proceed under the condition of containing the monomers at a high concentration. Specifically, this invention is directed toward a method for producing a powdered polycarboxylic acid type cement dispersant, which method comprises a step of polymerizing the monomers under the condition of containing the monomers at a concentration of 50-100 mass % based on the total mss of the monomers and the solvent, a step of cooling the formed polymer thereby solidifying the polymer, and a step of pulverizing the solidified polymer.Type: ApplicationFiled: July 11, 2005Publication date: November 1, 2007Applicant: NIPPON SHOKUBAI CO., LTD.Inventors: Tsuyoshi Hirata, Hirokatsu Kawakami
-
Publication number: 20070181042Abstract: An additive for a hydraulic material which comprises a polyamine compound having a hydrocarbon group of 4-30 carbon atoms as a side chain as an essential component is provided. The additive can effectively reduce the drying shrinkage of a cement material.Type: ApplicationFiled: March 15, 2005Publication date: August 9, 2007Applicant: Nippon Shokubai Co., Ltd.Inventors: Mari Masanaga, Tsuyoshi Hirata
-
Patent number: 7253220Abstract: The cement admixture of the present invention can improve the workability by displaying sufficient viscosity decreasing ability and initial dispersing ability even under a low temperature environment as well as high dispersing ability and dispersion retaining ability even in a high water reducing ratio range. The above-mentioned cement admixture comprises four components of a copolymer (A) containing a constituent unit (I) derived from the unsaturated (poly)alkylene glycol ether monomer (a) and a constituent unit (II) derived from a maleic acid monomer (b), a specific unsaturated (poly)alkylene glycol ether monomer (a), a non-polymerizable (poly)alkylene glycol (B) having no alkenyl group, and a polymer (C) having an oxyalkylene group or a polyoxyalkylene group and a carboxyl group, which is different from the copolymer (A).Type: GrantFiled: March 4, 2004Date of Patent: August 7, 2007Assignee: Nippon Shokubai Co., Ltd.Inventors: Akihiko Yamashita, Hiromichi Tanaka, Toru Uno, Yoshiyuki Onda, Tsuyoshi Hirata