Patents by Inventor Tsuyoshi Maekawa

Tsuyoshi Maekawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060148858
    Abstract: A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, —O—, —S— and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents —OR4 (R4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.
    Type: Application
    Filed: May 22, 2003
    Publication date: July 6, 2006
    Inventors: Tsuyoshi Maekawa, Ryoma Hara, Hiroyuki Odaka, Hiroyuki Kimura, Hideya Mizufune, Kohji Fukatsu
  • Publication number: 20060135578
    Abstract: The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1- or -Z1-(CH2)n— (n is an integer of 0 to 8, Z1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R2 is a hydrogen atom, a cyano group, —PO(OR9)(OR10) (R9 and R10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R9 and R10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic act
    Type: Application
    Filed: September 9, 2003
    Publication date: June 22, 2006
    Inventors: Yu Momose, Nobuyuki Takakura, Tsuyoshi Maekawa, Hiroyuki Odaka, Hiroyuki Kimura
  • Publication number: 20060084690
    Abstract: A compound represented by the formula (I) wherein one of R1 and R2 is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic hydrocarbon group; Y is a group of the formula: —OR3 (wherein R is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group) or an optionally esterified or amidated carboxyl group, or a salt thereof or a prodrug thereof has a superior insulin secretion promoting action and a hypoglycemic action and shows low toxicity. Therefore, the compound is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of diabetes and diabetic complications, and the like.
    Type: Application
    Filed: December 6, 2005
    Publication date: April 20, 2006
    Inventors: Yu Momose, Tsuyoshi Maekawa, Tomoko Asakawa, Nozomu Sakai
  • Patent number: 7022725
    Abstract: A compound represented by the formula (I) wherein one of R1 and R2 is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic hydrocarbon group; Y is a group of the formula: —OR3 (wherein R3 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group) or an optionally esterified or amidated carboxyl group, or a salt thereof or a prodrug thereof has a superior insulin secretion promoting action and a hypoglycemic action and shows low toxicity. Therefore, the compound is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of diabetes and diabetic complications, and the like.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: April 4, 2006
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Yu Momose, Tsuyoshi Maekawa, Tomoko Asakawa, Nozomu Sakai
  • Publication number: 20060048883
    Abstract: A method of producing a radial tire for a construction vehicle, the method enabling a vast reduction in facility costs. A first green tire is formed in a first step molding machine and then removed from it. After that, a vulcanizer bladder unit is installed on the tire. The tire is inflated by the vulcanizer bladder unit and then again placed in the first step molding machine with the vulcanizer bladder unit installed. After that, on the first step molding machine, belts and tread rubber are adhered to the outer periphery of the tire to form a completed green tire. Then the completed green tire, with the vulcanizer bladder unit, is assembled in a vulcanizing mold for vulcanization.
    Type: Application
    Filed: March 5, 2004
    Publication date: March 9, 2006
    Inventors: Tsuyoshi Maekawa, Heikichi Nakanome, Ken Takahashi
  • Publication number: 20060004069
    Abstract: The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a divalent acyclic hydrocarbon group; Z is —O—, —S—, —NR2—, —CONR2— or —NR2CO— (R2 is a hydrogen atom or an optionally substituted alkyl group); Y is a bond or a divalent acyclic hydrocarbon group; R1 is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be —O—, or a salt thereof.
    Type: Application
    Filed: October 30, 2003
    Publication date: January 5, 2006
    Inventors: Yu Momose, Nozomu Sakai, Tsuyoshi Maekawa, Masatoshi Hazama, Toru Kawamura, Misayo Sera
  • Publication number: 20040157881
    Abstract: The present invention provides a retinoid-related receptor (except retinoic acid receptors) function regulating agent comprising a compound represented by the formula: 1
    Type: Application
    Filed: December 16, 2003
    Publication date: August 12, 2004
    Inventors: Tsuyoshi Maekawa, Jun Kunitomo, Hiroyuki Odaka, Hiroyuki Kimura
  • Publication number: 20040063775
    Abstract: The present invention relates to a compound represented by the formula 1
    Type: Application
    Filed: September 22, 2003
    Publication date: April 1, 2004
    Inventors: Yu Momose, Tsuyoshi Maekawa, Hiroshi Imoto, Hiroyuki Odaka, Hiroyuki Kimura
  • Publication number: 20040058965
    Abstract: An alkanoic acid derivative useful as a prophylactic or therapeutic agent of diabetes mellitus, hyperlipidemia, impaired glucose tolerance and the like can be provided by a compound represented by the formula 1
    Type: Application
    Filed: June 26, 2003
    Publication date: March 25, 2004
    Inventors: Yu Momose, Tsuyoshi Maekawa, Nobuyuki Takakura, Hiroyuki Odaka, Hiroyuki Kimura, Tatsuya Ito
  • Publication number: 20040048908
    Abstract: A compound represented by the formula (I) 1
    Type: Application
    Filed: May 14, 2003
    Publication date: March 11, 2004
    Inventors: Yu Momose, Tsuyoshi Maekawa, Tomoko Asakawa, Nozomu Sakai
  • Patent number: 6404652
    Abstract: A relay terminal includes a plurality of relays, a connector for entering control signals to control the relays and outputting contact inputs from their relay contacts, and a terminal block corresponding to the input and output signals of the relays, which are held as a single unit. The holding construction of the plurality of relays and the terminal block employs a two step overlapping holding construction in which the relays are held in an upper step and the terminal block is held in a lower step, resulting in a reduction in the width of the relay terminal and an increase in a package density when the relay terminal is mounted on a vertical installation wall within a control panel.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: June 11, 2002
    Assignee: Omron Corporation
    Inventors: Yasuhiro Takebayashi, Kazushige Matsuoka, Taisuke Ueda, Ryo Sugihara, Hirofumi Iwanaga, Tsuyoshi Maekawa
  • Patent number: 5891895
    Abstract: Hydroxypyridine derivatives of the formula ##STR1## wherein R.sup.1 is a branched C.sub.3-8 alkyl group or a C.sub.3-8 cycloalkyl group, each of which may be substituted;R.sup.2 is a halogen atom, a C.sub.1-4 alkyl group or a C.sub.1-4 alkoxy group;X is an oxygen atom or NR.sup.3 in which R.sup.3 is a hydrogen atom or a C.sub.1-4 alkyl group;R.sup.4, R.sup.5 and R.sup.6 are independently (1) a hydrogen atom, (2) a halogen atom, (3) a cyano group, (4) a nitro group, (5) a C.sub.1-4 acyl group, (6) a C.sub.1-4 alkoxy group which may be substituted with halogen, (7) a C.sub.1-4 alkyl group which may be substituted with halogen or (8) a mercapto group which may be substituted with a C.sub.1-4 alkyl group;m is 0 to 3; andn is 0 or 1;provided that all of R.sup.4, R.sup.5 and R.sup.6 are not hydrogen atom, or a salt thereof, which have potassium channel opening activity and are useful as therapeutic agents of cardiovascular diseases such as angina pectoris, hypertension, etc.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: April 6, 1999
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Mitsuru Shiraishi, Tsuyoshi Maekawa, Toshifumi Watanabe
  • Patent number: 4981712
    Abstract: In producing a thin-film electroluminescent device having a ZnS:Mn film deposited by a MOCVD process using a mixed gas containing an organic zinc compound, an organic sulfur compound and an organic manganese compound, either methyl mercaptan or ethyl mercaptan is used as the sulfur compound and di.pi.-cyclopentadienylmanganese as the manganese compound. The zinc compound is preferably dimethylzinc or diethylzinc. As the merits of using such a combination of organic metal compounds the MOCVD operation can be accomplished at a relatively low substrate temperature, and the deposited ZnS:Mn film is high in the light emitting efficiency and low in the threshold voltage.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: January 1, 1991
    Assignee: Central Glass Company, Limited
    Inventors: Yuji Yamamoto, Tsuyoshi Maekawa, Kazutoshi Nakaya