Patents by Inventor Tsuyoshi Shimose

Tsuyoshi Shimose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8188308
    Abstract: Disclosed is a crystal of glutathione having an average width of 7 to 40 ?m and an average particle diameter of 10 to 60 ?m, preferably having an angle of repose of 53 degree or less, more preferably having a crude specific volume of 5.0 cm3/g or less, still more preferably in the form of an alpha-form crystal. Also disclosed is a tablet containing such a crystal of glutathione. Further disclosed is a process for producing such a crystal of glutathione.
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: May 29, 2012
    Assignee: Kyowa Hakko Bio Co., Ltd.
    Inventors: Tsuyoshi Shimose, Hideki Murata, Tadashi Hayashi, Takahiro Sakuma
  • Patent number: 7888078
    Abstract: The present invention provides: a process for producing an amino acid which comprises adding crystals of the amino acid having an average particle size of 1 to 120 ?m to a medium so that the concentration of the crystals of the amino acid becomes 0.5 g/l or more, culturing a microorganism having the ability to produce the amino acid in the medium, allowing crystals of the amino acid to form and accumulate in the medium, and recovering the crystals of the amino acid from the culture; and a process for producing an amino acid which comprises adding crystals of the amino acid to a medium so that the total surface area of the crystals of the amino acid in the medium becomes 0.02 m2/l, culturing a microorganism having the ability to produce the amino acid in the medium, allowing crystals of the amino acid to form and accumulate in the medium, and recovering the crystals of the amino acid from the culture.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: February 15, 2011
    Assignee: Kyowa Hakko Bio Co., Ltd.
    Inventors: Tsuyoshi Shimose, Ryou Ohashi, Katsumi Fujinaga
  • Publication number: 20100099847
    Abstract: Disclosed is a crystal of glutathione having an average width of 7 to 40 ?m and an average particle diameter of 10 to 60 ?m, preferably having an angle of repose of 53 degree or less, more preferably having a crude specific volume of 5.0 cm3/g or less, still more preferably in the form of an alpha-form crystal. Also disclosed is a tablet containing such a crystal of glutathione. Further disclosed is a process for producing such a crystal of glutathione.
    Type: Application
    Filed: October 16, 2007
    Publication date: April 22, 2010
    Applicant: Kyowa Hakko Bio Co., Ltd.
    Inventors: Tsuyoshi Shimose, Hideki Murata, Tadashi Hayashi, Takahiro Sakuma
  • Publication number: 20090081739
    Abstract: The present invention provides: a process for producing an amino acid which comprises adding crystals of the amino acid having an average particle size of 1 to 120 ?m to a medium so that the concentration of the crystals of the amino acid becomes 0.5 g/l or more, culturing a microorganism having the ability to produce the amino acid in the medium, allowing crystals of the amino acid to form and accumulate in the medium, and recovering the crystals of the amino acid from the culture; and a process for producing an amino acid which comprises adding crystals of the amino acid to a medium so that the total surface area of the crystals of the amino acid in the medium becomes 0.02 m2/l, culturing a microorganism having the ability to produce the amino acid in the medium, allowing crystals of the amino acid to form and accumulate in the medium, and recovering the crystals of the amino acid from the culture.
    Type: Application
    Filed: April 12, 2006
    Publication date: March 26, 2009
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Tsuyoshi Shimose, Ryou Ohashi, Katsumi Fujinaga
  • Patent number: 7094870
    Abstract: The present invention provides crystals of glutathione oxidized n hydrate (wherein n is an integer or a fraction of not less than 0 and less than 8) useful, for example, as final products of, as raw materials for, or as intermediates of health foods, pharmaceuticals, cosmetics or the like, and a process for producing crystals of glutathione oxidized, which comprises a step of crystallizing glutathione oxidized from a mixture of an aqueous solution containing glutathione oxidized and a water-miscible organic solvent and which is suitable for large-scale synthesis or industrialization.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: August 22, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tsuyoshi Shimose, Hideki Murata
  • Publication number: 20040250751
    Abstract: The present invention provides crystals of glutathione oxidized n hydrate (wherein n is an integer or a fraction of not less than 0 and less than 8) useful, for example, as final products of, as raw materials for, or as intermediates of health foods, pharmaceuticals, cosmetics or the like, and a process for producing crystals of glutathione oxidized, which comprises a step of crystallizing glutathione oxidized from a mixture of an aqueous solution containing glutathione oxidized and a water-miscible organic solvent and which is suitable for large-scale synthesis or industrialization.
    Type: Application
    Filed: April 7, 2004
    Publication date: December 16, 2004
    Inventors: Tsuyoshi Shimose, Hideki Murata
  • Publication number: 20040149200
    Abstract: The present invention provides crystals of an oligosaccharide useful, for example, as raw materials for or as intermediates of health foods, pharmaceutical compositions, cosmetics, etc. and a process for producing crystals of an oligosaccharide which is suitable for large-scale synthesis or industrialization.
    Type: Application
    Filed: November 26, 2003
    Publication date: August 5, 2004
    Inventors: Tsuyoshi Shimose, Hiroshi Nagano, Masaru Arimoto, Hideki Murata
  • Patent number: RE45723
    Abstract: The present invention provides: a process for producing an amino acid which comprises adding crystals of the amino acid having an average particle size of 1 to 120 ?m to a medium so that the concentration of the crystals of the amino acid becomes 0.5 g/l or more, culturing a microorganism having the ability to produce the amino acid in the medium, allowing crystals of the amino acid to form and accumulate in the medium, and recovering the crystals of the amino acid from the culture; and a process for producing an amino acid which comprises adding crystals of the amino acid to a medium so that the total surface area of the crystals of the amino acid in the medium becomes 0.02 m2/l, culturing a microorganism having the ability to produce the amino acid in the medium, allowing crystals of the amino acid to form and accumulate in the medium, and recovering the crystals of the amino acid from the culture.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: October 6, 2015
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Tsuyoshi Shimose, Ryou Ohashi, Katsumi Fujinaga