Abstract: A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or 2-lower alkyl-benzothiophene with a substituted benzene derivative, itaconic acid derivative or a substituted phenoxymethyl tetrazole derivative. They are useful as diuretics without side effects of elevating serum uric acid levels and can be used in the treatment of hyperuricemia.

Abstract: New antiarrythmic diamines are disclosed. pa These new compounds are represented by the following general formula: ##STR1## wherein: A is NO.sub.2, RSO.sub.2 NH or RSO.sub.2, whereinR represents a lower alkyl group.B is >CH.sub.2 or >C.dbd.O,Y is a lower alkyl group,Z is a lower alkyl or benzyl group,n is an integer 2 or 3.The compounds of the present invention are useful as antiarrhythmic agents.

Abstract: A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or 2-lower alkyl-benzothiophene with a substituted benzene derivative, itaconic acid derivative or a substituted phenoxymethyl tetrazole derivative. They are useful as diuretics without side effects of elevating serum uric acid levels and can be used in the treatment of hyperuricemia.

Abstract: A new series of 1,5-benzothiazepine analogues are disclosed. These compounds are represented by the following general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrogen, a lower alkyl, nitro, amino, lower-alkyl-oxy or halogen group, X represents O or S. These compounds are useful as anti-hypertensive agents.

Abstract: New quinazoline derivatives are disclosed, as represented by the following formula: ##STR1## wherein A is hydrogen atom or lower alkyloxy group; R.sub.4 is hydrogen atom, a lower alkyl, lower alkyloxy or a halogen atom group. Y is hydrogen atom, lower alkyloxy, sulfamoyl or Y and R.sub.4, taken together, are joined to form --O--CH.sub.2 --CH.sub.2 --O--; Z is a 4-oxopiperidino, 4-thioxopiperidino, 4-oximepiperidino, 4-O-loweralkyl-oxime-piperidino, 4-O-(3-lower alkyl-2-hydroxypropyl)-oxime-piperidino, 4-O-(3-lower alkylamino-2-hydroxypropyl)-oxime-piperidino or 4-O-(3-N'-lower alkyl, N'-benzylamino-2-hydroxypropyl)-oxime-piperidino group. These compounds are useful as anti-hypertensive agents.

Abstract: Derivatives of 2-substituted-cycloheptoimidazole are disclosed, which are represented by the following formula: ##STR1## wherein R is a hydrogen atom, a lower-alkyl, acetyl, lower-alkylaminoalkyl or ethylenedioxyethyl group. A represents a phenyl, pyridyl, benzimidazolyl, imidazolyl, thiazolyl, thiadiazolyl, oxazolyl or isoxazolyl group; each of which optionally possesses one substituent or more and m is 0 or 1, and n is 1 or 2. These compounds are useful as anti-ulcerative agents.

Abstract: New agents of carbacyclin derivatives are disclosed, which are represented by the following formula: ##STR1## wherein A is a --CH.dbd.CH-- or --C.tbd.C-- group. B is a substituted or unsubstituted indanyl group, substituted or unsubstituted benzodioxanyl group, substituted or unsubstituted benzodioxolanyl group or 2,3,5,6,7, 8-hexahydrobenzodioxanyl group. D is --CH.sub.2 -- or --O--. .about.OH group represents .alpha. or .beta. configuration of OH group; and ##STR2## These compounds are useful as anit-ulcer, anti-hypertensive or anti-thrombotic agents.

Abstract: A series of new 1,3-dioxane derivatives are disclosed. These compounds have an outstanding anti-peptic ulcerative activity and are useful as novel anti-peptic ulcer agents. Such compounds are synthesized by reacting a 1,3-butanediol derivative with suitable ketone.

Abstract: A new series of azulene derivatives are disclosed. These compounds are stable to light and heat and are useful as anti-ulcerative and anti-inflammatory agents. Such compounds can be synthesized by reacting 2H-cyclohepta(b) furan-2-one or its derivative substituted by a lower alkyl with a suitable enamine derived from a corresponding aldehyde or ketone, and then sulfonating the compound resulting from said reaction.

Abstract: A series of new 1,5-benzothiazepine analogues are disclosed.These new compounds are represented by the following general formula: ##STR1## wherein : A is >C.dbd.O or >CH.sub.2,n is an integer from 1 to 3,B is ##STR2## wherein R.sup.1 represents H, alkyl or acyl group; R.sup.2 is ##STR3## D represents ##STR4## wherein n' and n" each represents 1 or 2. R, R', R" each represents a lower alkyl, Ph represents phenyl group or a substituted phenyl group.The compounds of the present invention are useful as hypertensive agents.

Abstract: A series of new 2,4-substituted thiazole derivatives are disclosed. These compounds have anti-histaminergic activity, especially, outstanding gastric anti-secretory activity.The compounds of this invention are obtained mainly by reacting 2-substituted-4-aminoalkyl-thiomethyl thiazole with a compound having methylthio or hydroxy group corresponding thereto.

Abstract: A series of new thiazole derivatives are disclosed. These compounds have an outstanding anti-gastric secretion activity. The compounds of this invention can be obtained by reacting 4-halogenated-alkyl-thiazole with its corresponding piperidine derivative or piperazine derivative.

Abstract: Some new compounds, farnesyl farnesyl carboxylate, N-farnesyl farnesyl carboxamide and N-farnesyl farnesyl carbamate are disclosed, which are novel mucosal stabilizing agents showing anti-inflammative and anti-ulcerative activities. These new compounds are prepared by the reaction of farnesyl carboxylic acid with farnesol or farnesylamine.

Abstract: New derivatives of 3-furyl-, 3-thienyl- and 3-phenyl-2-propenimidamides are disclosed, which are useful as anti-ulcer agents. These new compounds are synthesized by reacting an imino ether derived from a corresponding 3-substituted-2-propenenitrile with a suitable amine.

Abstract: A new compound, farnesyl carboxylic acid .alpha.-bisabolol ester is disclosed, which is a novel mucosal stabilizing agent showing anti-inflammative and anti-ulcerative activities. This new compound is especially useful in the treatment of gastric ulcer. The compound is synthesized by esterification of farnesyl carboxylic acid or its derivatives with .alpha.-bisabolol or a derivative thereof.