Abstract: The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. To be specific, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.

Abstract: A manufacturing method for quasi phase matching (QPM) wavelength converter elements using crystal quartz as a base material in which twins are periodically induced, comprises a step of periodically inducing the twins by applying a stress onto a crystal quartz substrate as the base material so that an angle ? of a direction in which the stress is applied relative to a Z axis of the crystal quartz is 60°<?<90°.

Abstract: A laser treatment apparatus for performing treatment by irradiating an affected part with a laser beam comprises: a laser source capable of emitting beams of a plurality of different wavelengths; a first setting unit which sets an irradiation amount of a laser beam for treatment of a wavelength to be used for treatment; an emission amount changing unit which changes an emission amount of the beam in plural levels; an attenuating unit which attenuates the beam emitted by the laser source; and a control part which controls the emission amount changing unit and the attenuating unit based on the set irradiation amount of the treatment beam.

Abstract: A manufacturing method for quasi phase matching (QPM) wavelength converter elements using crystal quartz as a base material in which twins are periodically induced, comprises a step of periodically inducing the twins by applying a stress onto a crystal quartz substrate as the base material so that an angle ? of a direction in which the stress is applied relative to a Z axis of the crystal quartz is 60°<?<90°.

Abstract: A laser apparatus capable of emitting laser beams of a plurality of different wavelengths includes: a solid-state laser medium which emits light of a plurality of different peak wavelengths; a resonance optical system which resonates the emitted light of the plurality of different peak wavelengths and converts respective light to oscillate the laser beams of the plurality of different wavelengths; and a ¼ wave plate for a wide band, which is placed in the resonance optical system and has a property of providing a uniform phase difference to the light of the plurality of different peak wavelengths to be converted.

Abstract: The present invention is intended to elucidate a molecular target of an antidiabetic such as a thiazolidine derivative. The present invention provides a screening method for an antidiabetic, comprising the steps of: bringing a candidate substance to be screened into contact with a protein represented by the following (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 2; or (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 with the deletion, substitution, addition, or insertion of one or plural amino acids and interacting with the antidiabetic; and detecting the interaction between the candidate substance and the protein.

Abstract: Provided is a capillary tube flow cell used in analyses at very low flow rates and, particularly, in liquid chromatographic analyses. To ensure that high detection sensitivity and low noise can be realized, a flow cell which houses a liquid sample and exposes the liquid sample to radiant light for analysis purposes comprises a capillary tube which has a bent portion for incident light, a bent portion for emergent light and a linear passage of appropriate length formed between the bent portions, a passage portion of the capillary tube being inserted into a slit and the slit being provided with a light pass preventing portion.

Abstract: A medical laser apparatus for performing treatment by irradiating an affected part with a laser beam comprises: a fiber laser source with variable output power, which emits an infrared fundamental laser beam; a wavelength converting element which wavelength-converts the fundamental beam to a visible second harmonic laser beam and is placed on an optical axis of the fundamental beam; a first incident angle changing unit which changes an incident angle of the fundamental beam to the wavelength converting element; an optical axis deviation correcting unit which corrects deviation of an optical axis of the second harmonic beam caused by a change of the incident angle of the fundamental beam to the wavelength converting element; and a controller which controls the first changing unit and the correcting unit based on a change in power of the fundamental beam.

Abstract: The present invention provides a novel protein that regulates degranulation of mast cells (degranulation regulator), a gene encoding it, a protein (conjugate factor) that interacts with the regulator, a gene encoding it, a screening method of an inhibitor of the degranulation, which uses this degranulation regulator and the conjugate factor, an inhibitor obtained by the screening method and the like.

Abstract: A medical laser apparatus for irradiating an affected tissue with a laser beam to treat the affected tissue, comprises: a laser source unit which emits an infrared beam as a fundamental wave having a spectral bandwidth; a wavelength demultiplexing optical system which spatially demultiplexes the emitted infrared beam by wavelengths; a wavelength converting optical system including a wavelength converting element disposed in correspondence with an optical path position of each of the demultiplexed infrared beams and for converting each of the infrared beams to a visible beam as a second harmonic wave; a wavelength multiplexing optical system which multiplexes the visible beams obtained by the conversion; and a delivery optical system which guides the multiplexed visible beams to the affected tissue.

Abstract: The present invention provides a process for producing an antithrombin III composition comprising an antithrombin III molecule having complex type N-glycoside-linked sugar chains, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains.

Abstract: A laser treatment apparatus for performing treatment by irradiating an affected part with a laser beam comprises: a laser source capable of emitting beams of a plurality of different wavelengths; a first setting unit which sets an irradiation amount of a laser beam for treatment of a wavelength to be used for treatment; an emission amount changing unit which changes an emission amount of the beam in plural levels; an attenuating unit which attenuates the beam emitted by the laser source; and a control part which controls the emission amount changing unit and the attenuating unit based on the set irradiation amount of the treatment beam.

Abstract: A laser apparatus capable of emitting laser beams of a plurality of different wavelengths includes: a solid-state laser medium which emits light of a plurality of different peak wavelengths; a resonance optical system which resonates the emitted light of the plurality of different peak wavelengths and converts respective light to oscillate the laser beams of the plurality of different wavelengths; and a ¼ wave plate for a wide band, which is placed in the resonance optical system and has a property of providing a uniform phase difference to the light of the plurality of different peak wavelengths to be converted.

Abstract: A manufacturing method for quasi phase matching (QPM) wavelength converter elements using crystal quartz as a base material in which twins are periodically induced, comprises a step of periodically inducing the twins by applying a stress onto a crystal quartz substrate as the base material so that an angle e of a direction in which the stress is applied relative to a Z axis of the crystal quartz is 60°<&thgr;<90°.

Abstract: A circuit simulator performs a simulation for each tester using, as input values, tester parameters, test board parameters, and chip parameters. A difference acquiring section produces difference data of simulation results. A program converting section converts a test program for a first tester into a test program for a second tester based on the produced difference data. With this program conversion system, the load of tester replacement work can be reduced in the case where LSI products need to be tested by using different testers.

Abstract: A hinge part (3) includes a first hinge part (1f) as a fitted part, which is formed by cutting out one of side parts of a first housing (1), and a second hinge part (32a), (3b), which is a fitting part protruded from one of the side parts of an inner surface (2A) of a second housing (2) toward an inner surface (1A) of the first housing (1), and rotatably engages with the first hinge part (1f), wherein the first hinge part (1f) and the second hinge part (32a), (3b) are not bulged out of the inner surface of the first housing (1). With such a mechanical arrangement, when the first housing (1) is placed on a work surface and the second housing (2) is opened, the side part of the first housing (1) which is closer to the a first hinge part (1f) is raised.

Abstract: Intermediacy between a company outsourcing semiconductor device testing, and a outsource company conducting the semiconductor device testing is accomplished by prompting the outsourcing company to input conditions required for the semiconductor testing, registering the inputted conditions, selecting an outsource company based on the conditions from among a plurality of outsource companies conducting semiconductor device testing, and presenting a list indicating the selected outsource company and its conditions to the outsourcing company.

Abstract: A circuit simulator performs a simulation for each tester using, as input values, tester parameters, test board parameters, and chip parameters. A difference acquiring section produces difference data of simulation results. A program converting section converts a test program for a first tester into a test program for a second tester based on the produced difference data. With this program conversion system, the load of tester replacement work can be reduced in the case where LSI products need to be tested by using different testers.

Abstract: The present invention provides a novel protein that regulates degranulation of mast cells (degranulation regulator), a gene encoding it, a protein (conjugate factor) that interacts with the regulator, a gene encoding it, a screening method of an inhibitor of the degranulation, which uses this degranulation regulator and the conjugate factor, an inhibitor obtained by the screening method and the like.

Abstract: A system in which a terminal of a program developer and a program conversion system are connected to each other via a network. The program conversion system is provided with a program sending/receiving device for sending a generated conversion destination program to and receiving a conversion source program from the terminal of the program developer, emulation devices corresponding to different conversion source programs, respectively, for generating intermediate-language programs by converting the conversion source programs, conversion devices corresponding to different conversion destination programs, respectively, for generating the conversion destination programs by converting the intermediate-language programs, a first selecting section for selecting one of the plurality of emulation devices, and a second selecting section for selecting one of the plurality of conversion devices.