Abstract: The invention relates to methods of diagnosing or monitoring a psychotic disorder in a subject comprising providing a test biological sample from the subject, performing spectral analysis on said test biological sample to provide one or more spectra, and, comparing the one or more spectra with one or more control spectra. The invention also relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarkers present in a biological sample taken from a test subject, said biomarkers being selected from the group consisting of transthyretin, ApoA1: VLDL, LDL and aromatic species such as plasma proteins. The invention also relates to sensors, biosensors, multi-analyte panels, arrays, assays and kits for performing methods of the invention.

Abstract: The invention relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarker(s) present in a cerebrospinal fluid sample taken from a test subject, said biomarker(s) being selected from the group consisting of: glucose, lactate, acetate species and pH. The invention also relates to methods of diagnosing or monitoring a psychotic disorder in a subject comprising providing a test sample of CSF from the subject, performing spectral analysis on said CSF test sample to provide one or more spectra, and, comparing the one or more spectra with one or more control spectra. The invention also relates to sensors, biosensors, multi-analyte panels, arrays, assays and kits for performing methods of the invention.