Patents by Inventor Tsz Ying Yuen

Tsz Ying Yuen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220267376
    Abstract: Peptidomimetic macrocycles that comprise all-D configuration ?-amino acids and bind mouse double minute 2 (MDM2 aka E3 ubiquitin-protein ligase) and MDMX (aka MDM4) are described. These all-D configuration ?-amino acid peptidomimetic macrocycles are protease resistant, cell permeable without inducing membrane disruption, and intracellularly activate p53 by binding MDM2 and MDMX thereby antagonizing MDM2 and MDMX binding to p53. These peptidomimetic macrocycles may be useful in anticancer therapies, particularly in combination with chemotherapy or radiation therapy.
    Type: Application
    Filed: June 16, 2020
    Publication date: August 25, 2022
    Applicants: Merck Sharp & Dohme Corp., Agency for Science, Technology and Research, MSD International GMBH (Singapore Branch)
    Inventors: Pietro Aronica, Christopher J. Brown, Fernando J. Ferrer, Charles W. Johannes, Srinivasaraghavan Kannan, David P. Lane, Anthony W. Partridge, Tomi K. Sawyer, Yaw Sing Tan, Chandra S. Verma, Tsz Ying Yuen
  • Patent number: 11236128
    Abstract: Described herein is an operationally simple, one-pot solid-supported preparation of saturated stapled peptides. Following completion of ruthenium-catalysed metathesis, solid-phase transfer hydrogenation was achieved using triethylhydrosilane at elevated temperatures. The utility of the method has been demonstrated on 14- and 16-mer peptides to yield the corresponding cyclic a-helix stabilised stapled peptides.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: February 1, 2022
    Assignee: Agency for Science, Technology and Research
    Inventors: Tsz Ying Yuen, Charles William Johannes, Gerard Hilinski
  • Patent number: 11091427
    Abstract: This invention relates to a method for producing an alkenyl 1-aminocyclopropane-1-carboxylic acid of Formula I wherein R1 is a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B is R and when A is R, B is S. The method comprises a stereoselective formation of the cyclopropane moiety by cycloaddition onto a double bond, in a molecule comprising a chiral template, Formula lc. Further provided is the use of Formula I in the production of stapled peptides.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: August 17, 2021
    Assignee: Agency for Science, Technology and Research
    Inventors: Tsz Ying Yuen, Charles William Johannes, Greg Verdine
  • Publication number: 20210139538
    Abstract: Described herein is an operationally simple, one-pot solid-supported preparation of saturated stapled peptides. Following completion of ruthenium-catalysed metathesis, solid-phase transfer hydrogenation was achieved using triethylhydrosilane at elevated temperatures. The utility of the method has been demonstrated on 14- and 16-mer peptides to yield the corresponding cyclic a-helix stabilised stapled peptides.
    Type: Application
    Filed: July 31, 2018
    Publication date: May 13, 2021
    Applicant: Agency for Science, Technology and Research
    Inventors: Tsz Ying YUEN, Charles William JOHANNES, Gerard HILINSKI
  • Publication number: 20210122781
    Abstract: This invention relates to a process for producing a compound of Formula I, comprising: 1) performing a stereoselective metathesis reaction on a compound of Formula II so as to form an intramolecular alkenyl chain, and 2) cleaving S from P2 so as to produce a compound of Formula I. A product containing an (Z)- or (E)-olefin isomer stabilised in an a-helical conformation is obtained by the said process.
    Type: Application
    Filed: March 26, 2018
    Publication date: April 29, 2021
    Inventors: Tsz Ying Yuen, Charles William Johannes, Fernando Jose Ferrer Gago
  • Publication number: 20200031760
    Abstract: This invention relates to a method for producing an alkenyl 1-aminocyclopropane-1-carboxylic acid of Formula I wherein R1 is a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B is R and when A is R, B is S. The method comprises a stereoselective formation of the cyclopropane moiety by cycloaddition onto a double bond, in a molecule comprising a chiral template, Formula lc. Further provided is the use of Formula I in the production of stapled peptides.
    Type: Application
    Filed: March 23, 2018
    Publication date: January 30, 2020
    Inventors: Tsz Ying Yuen, Charles William Johannes, Greg Verdins