Abstract: An in-mold lid closing apparatus includes a lid engagement member, a first actuation assembly connected to a first portion of the lid engagement member, a second actuation assembly connected to a second opposing portion of the lid engagement member, and a controller disposed in electrical communication with the first actuation assembly and the second actuation assembly. The controller is configured to transmit a first drive signal to the first actuation assembly and a second drive signal to the second actuation assembly to drive one of a linear position and a rotational position of the lid engagement member and to adjust at least one of the first drive signal and the second drive signal based upon a first feedback signal received from the first actuation assembly and a second feedback signal received from the second actuation assembly.

Abstract: A mechanical interlock pin assembly includes a shaft having a first end and a second end. The mechanical interlock pin assembly includes a set of helical spline elements disposed at the first end of the shaft, the set of helical spline elements extending along a longitudinal axis of the shaft. The mechanical interlock pin assembly includes a bearing rotatably coupled to the second end of the shaft, the bearing configured to allow rotation of the shaft between a first rotational position and a second rotational position relative to a mold cavity.

Abstract: A hydraulic advancement/postponement assembly is operably coupled to a first ejector plate and to a second ejector plate. The hydraulic advancement/postponement assembly includes a first hydraulic cylinder having a first housing defining a first volume and a first piston, the first housing connected to the first ejector plate and the first piston connected to a fixed element. The hydraulic advancement/postponement assembly includes a second hydraulic cylinder disposed in fluid communication with the first hydraulic cylinder, the second hydraulic cylinder having a second housing defining a second volume and a second piston, the second housing connected to the first ejector plate and a second piston connected to the second ejector plate.

Abstract: A mechanical interlock pin assembly includes a shaft having a first end and a second end. The mechanical interlock pin assembly includes a set of helical spline elements disposed at the first end of the shaft, the set of helical spline elements extending along a longitudinal axis of the shaft. The mechanical interlock pin assembly includes a bearing rotatably coupled to the second end of the shaft, the bearing configured to allow rotation of the shaft between a first rotational position and a second rotational position relative to a mold cavity.

Abstract: A mechanical interlock pin assembly includes a shaft having a first end and a second end. The mechanical interlock pin assembly includes a set of helical spline elements disposed at the first end of the shaft, the set of helical spline elements extending along a longitudinal axis of the shaft. The mechanical interlock pin assembly includes a bearing rotatably coupled to the second end of the shaft, the bearing configured to allow rotation of the shaft between a first rotational position and a second rotational position relative to a mold cavity.

Abstract: An in-mold lid closing apparatus includes a lid engagement member, a first actuation assembly connected to a first portion of the lid engagement member, a second actuation assembly connected to a second opposing portion of the lid engagement member, and a controller disposed in electrical communication with the first actuation assembly and the second actuation assembly. The controller is configured to transmit a first drive signal to the first actuation assembly and a second drive signal to the second actuation assembly to drive one of a linear position and a rotational position of the lid engagement member and to adjust at least one of the first drive signal and the second drive signal based upon a first feedback signal received from the first actuation assembly and a second feedback signal received from the second actuation assembly.

Abstract: Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.

Abstract: A hydraulic advancement/postponement assembly is operably coupled to a first ejector plate and to a second ejector plate. The hydraulic advancement/postponement assembly includes a first hydraulic cylinder having a first housing defining a first volume and a first piston, the first housing connected to the first ejector plate and the first piston connected to a fixed element. The hydraulic advancement/postponement assembly includes a second hydraulic cylinder disposed in fluid communication with the first hydraulic cylinder, the second hydraulic cylinder having a second housing defining a second volume and a second piston, the second housing connected to the first ejector plate and a second piston connected to the second ejector plate.

Abstract: An in-mold lid closing apparatus includes a lid engagement member, a first actuation assembly connected to a first portion of the lid engagement member, a second actuation assembly connected to a second opposing portion of the lid engagement member, and a controller disposed in electrical communication with the first actuation assembly and the second actuation assembly. The controller is configured to transmit a first drive signal to the first actuation assembly and a second drive signal to the second actuation assembly to drive one of a linear position and a rotational position of the lid engagement member and to adjust at least one of the first drive signal and the second drive signal based upon a first feedback signal received from the first actuation assembly and a second feedback signal received from the second actuation assembly.

Abstract: A hydraulic advancement/postponement assembly is operably coupled to a first ejector plate and to a second ejector plate. The hydraulic advancement/postponement assembly includes a first hydraulic cylinder having a first housing defining a first volume and a first piston, the first housing connected to the first ejector plate and the first piston connected to a fixed element. The hydraulic advancement/postponement assembly includes a second hydraulic cylinder disposed in fluid communication with the first hydraulic cylinder, the second hydraulic cylinder having a second housing defining a second volume and a second piston, the second housing connected to the first ejector plate and a second piston connected to the second ejector plate.

Abstract: A threaded mold decoupling system comprises a set of unscrewing assemblies, each unscrewing assembly disposed in proximity to a corresponding threaded core of a set of threaded cores and having an unscrewing element defining an unscrewing element circumference and a driving element disposed in operative communication with an unscrewing assembly of the at least one set of unscrewing assemblies. The driving element defines a driving element circumference, a ratio of the driving element circumference to the unscrewing element circumference defining a number of rotations of each unscrewing element relative to a number of rotations of the driving element. The driving element is configured to rotate each unscrewing element in a first direction between a first position and a second position to decouple each threaded core from a corresponding molded article and in a second direction between the second position and the first position to reset each unscrewing assembly.

Abstract: A threaded mold decoupling system includes at least one unscrewing assembly configured to remove a molded article a threaded core of an injection mold, an elevator assembly, and a driving element disposed in operative communication with the at least one unscrewing assembly and with the elevator assembly. The driving element is configured to actuate the at least one unscrewing assembly to rotate a molded article about a longitudinal axis of the threaded core and actuate the elevator assembly to linearly translate the molded article along the longitudinal axis of the threaded core.

Abstract: Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.

Abstract: An in-mold lid closing apparatus includes a lid engagement member, a first actuation assembly connected to a first portion of the lid engagement member, a second actuation assembly connected to a second opposing portion of the lid engagement member, and a controller disposed in electrical communication with the first actuation assembly and the second actuation assembly. The controller is configured to transmit a first drive signal to the first actuation assembly and a second drive signal to the second actuation assembly to drive one of a linear position and a rotational position of the lid engagement member and to adjust at least one of the first drive signal and the second drive signal based upon a first feedback signal received from the first actuation assembly and a second feedback signal received from the second actuation assembly.

Abstract: A hydraulic advancement/postponement assembly is operably coupled to a first ejector plate and to a second ejector plate. The hydraulic advancement/postponement assembly includes a first hydraulic cylinder having a first housing defining a first volume and a first piston, the first housing connected to the first ejector plate and the first piston connected to a fixed element. The hydraulic advancement/postponement assembly includes a second hydraulic cylinder disposed in fluid communication with the first hydraulic cylinder, the second hydraulic cylinder having a second housing defining a second volume and a second piston, the second housing connected to the first ejector plate and a second piston connected to the second ejector plate.

Abstract: A threaded mold decoupling system includes at least one unscrewing assembly configured to remove a molded article a threaded core of an injection mold, an elevator assembly, and a driving element disposed in operative communication with the at least one unscrewing assembly and with the elevator assembly. The driving element is configured to actuate the at least one unscrewing assembly to rotate a molded article about a longitudinal axis of the threaded core and actuate the elevator assembly to linearly translate the molded article along the longitudinal axis of the threaded core.

Abstract: A mechanical interlock pin assembly includes a shaft having a first end and a second end. The mechanical interlock pin assembly includes a set of helical spline elements disposed at the first end of the shaft, the set of helical spline elements extending along a longitudinal axis of the shaft. The mechanical interlock pin assembly includes a bearing rotatably coupled to the second end of the shaft, the bearing configured to allow rotation of the shaft between a first rotational position and a second rotational position relative to a mold cavity.

Abstract: Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.

Abstract: A threaded mold decoupling system includes at least one unscrewing assembly rotatably coupled to a mounting plate and disposed in proximity to a threaded core of an injection mold, an elevator assembly having a first elevator element rotatably coupled to the mounting plate and a second elevator element connected to a fixed plate, the fixed plate opposing the mounting plate, and a driving assembly disposed in operative communication with the at least one unscrewing assembly and with the first elevator element of the elevator assembly. The driving assembly is configured to actuate the at least one unscrewing assembly to rotate a molded article about a longitudinal axis of the threaded core and actuate the first elevator element relative to the second elevator element to linearly translate the mounting plate relative to the fixed plate and to translate the molded article along the longitudinal axis of the threaded core.

Abstract: A threaded mold decoupling system includes at least one unscrewing assembly rotatably coupled to a mounting plate and disposed in proximity to a threaded core of an injection mold, an elevator assembly having a first elevator element rotatably coupled to the mounting plate and a second elevator element connected to a fixed plate, the fixed plate opposing the mounting plate, and a driving assembly disposed in operative communication with the at least one unscrewing assembly and with the first elevator element of the elevator assembly. The driving assembly is configured to actuate the at least one unscrewing assembly to rotate a molded article about a longitudinal axis of the threaded core and actuate the first elevator element relative to the second elevator element to linearly translate the mounting plate relative to the fixed plate and to translate the molded article along the longitudinal axis of the threaded core.