Patents by Inventor Tuan A. Elstrom

Tuan A. Elstrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10184907
    Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: January 22, 2019
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., James Joseph Koziarz, Douglas Adam Levinson, David A. Berry, Tuan A. Elstrom, Sonia Kumar, Mark John Audeh
  • Publication number: 20160033494
    Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.
    Type: Application
    Filed: October 8, 2015
    Publication date: February 4, 2016
    Inventors: Thomas Jay LOWERY, JR., James Joseph KOZIARZ, Douglas Adam LEVINSON, David A. BERRY, Tuan A. ELSTROM, Sonia KUMAR, Mark John AUDEH
  • Patent number: 8870810
    Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: October 28, 2014
    Assignee: Echo Therapeutics, Inc.
    Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F Warner, Tuan A Elstrom
  • Publication number: 20130035566
    Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.
    Type: Application
    Filed: September 13, 2012
    Publication date: February 7, 2013
    Applicant: ECHO THERAPEUTICS, INC.
    Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F. Warner, Tuan A. Elstrom
  • Patent number: 8287483
    Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area of the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: October 16, 2012
    Assignee: Echo Therapeutics, Inc.
    Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F. Warner, Tuan A. Elstrom
  • Publication number: 20110275985
    Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.
    Type: Application
    Filed: July 2, 2009
    Publication date: November 10, 2011
    Applicant: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, JR., James J. Koziarz, Douglas A. Levinson, David A. Berry, Tuan A. Elstrom, Sonia Kumar, Mark John Audeh
  • Publication number: 20110020785
    Abstract: This invention relates generally to a process for producing machine readable contextual diagnostic information and use of contextual diagnostic information for generating tangible and useful results. The process provides the highest level of integration of diagnostic information collected in a distributed or centralized system comprising diagnostic devices and a global computer network. More particularly, in certain embodiments, contextual diagnostic information are used in specific diagnostic related applications and business models including ecommerce.
    Type: Application
    Filed: July 28, 2008
    Publication date: January 27, 2011
    Applicant: T2 Biosystems, Inc.
    Inventors: Thomas J. Lowery, JR., Tuan A. Elstrom, Douglas A. Levinson, James J. Koziarz
  • Patent number: 7066884
    Abstract: A system, method, and device for non-invasive body fluid sampling is provided. According to one embodiment of the present invention, the system includes a controller that controls the generation of ultrasound; an ultrasonic applicator that applies the ultrasound to an area of biological membrane; a receiver that contacts the area of biological membrane and receives body fluid through and out of the area of biological membrane; and a meter that interacts with the receiver and detects the presence of at least one analyte in the body fluid in the receiver. The receiver may include a membrane and a medium, such as a hydrogel, a fluid, or a liquid, that is contained in the membrane.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: June 27, 2006
    Assignee: Sontra Medical, Inc.
    Inventors: Linda Custer, Tuan A. Elstrom, Scott C. Kellogg, Joseph Kost, Nicholas F. Warner
  • Patent number: 6887239
    Abstract: The invention provides a convenient and non-invasive means to prepare cells, tissues, and organs for electrical transmission and reception. In an embodiment of the invention, a control method comprises the use of at least one skin electrode, as a reference electrode, and an electrical sensor to measure periodically or continuously the skin's electrical conductance at the site of preparation. The dynamic change in the conductance through the skin is measured while the ultrasound is applied. Signal processing is performed on the measurement and the level of skin impedance change is controlled by performing a mathematical analysis and using the results of such analysis to control the application of ultrasonic energy. A desired level of skin impedance can be set at a predetermined value or based on a chosen level of skin integrity, subject's sensation of discomfort, or duration of the ultrasound application.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: May 3, 2005
    Assignee: Sontra Medical Inc.
    Inventors: Tuan A. Elstrom, Scott Kellogg, Joseph Kost, Samir S. Mitragotri, Nicolas F. Warner, Steve DiMatteo
  • Publication number: 20040236268
    Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area of the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.
    Type: Application
    Filed: March 5, 2004
    Publication date: November 25, 2004
    Applicant: Sontra Medical, Inc.
    Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F. Warner, Tuan A. Elstrom
  • Publication number: 20040171980
    Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area of the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.
    Type: Application
    Filed: March 5, 2004
    Publication date: September 2, 2004
    Applicant: Sontra Medical, Inc.
    Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F. Warner, Tuan A. Elstrom
  • Publication number: 20040039418
    Abstract: The invention provides a convenient and non-invasive means to prepare cells, tissues, and organs for electrical transmission and reception. In an embodiment of the invention, a control method comprises the use of at least one skin electrode, as a reference electrode, and an electrical sensor to measure periodically or continuously the skin's electrical conductance at the site of preparation. The dynamic change in the conductance through the skin is measured while the ultrasound is applied. Signal processing is performed on the measurement and the level of skin impedance change is controlled by performing a mathematical analysis and using the results of such analysis to control the application of ultrasonic energy. A desired level of skin impedance can be set at a predetermined value or based on a chosen level of skin integrity, subject's sensation of discomfort, or duration of the ultrasound application.
    Type: Application
    Filed: April 11, 2003
    Publication date: February 26, 2004
    Inventors: Tuan A. Elstrom, Scott Kellogg, Joseph Kost, Samir S. Mitragotri, Nicolas F. Warner, Steve DiMatteo
  • Publication number: 20030100846
    Abstract: A system, method, and device for non-invasive body fluid sampling is provided. According to one embodiment of the present invention, the system includes a controller that controls the generation of ultrasound; an ultrasonic applicator that applies the ultrasound to an area of biological membrane; a receiver that contacts the area of biological membrane and receives body fluid through and out of the area of biological membrane; and a meter that interacts with the receiver and detects the presence of at least one analyte in the body fluid in the receiver. The receiver may include a membrane and a medium, such as a hydrogel, a fluid, or a liquid, that is contained in the membrane.
    Type: Application
    Filed: March 11, 2002
    Publication date: May 29, 2003
    Inventors: Linda Custer, Tuan A. Elstrom, Scott C. Kellogg, Joseph Kost, Nicholas F. Warner
  • Patent number: 6294342
    Abstract: Assay methods utilizing the response of a magnetically responsive reagent to the influence of a magnetic field to qualitatively or quantitatively measure binding between specific binding pair members. According to the invention, the presence of an analyte mediates whether or not the magnetically responsive reagent binds to a mobile solid phase reagent. The extent of binding will modulate the response of the magnetically responsive reagent or that of the mobile solid phase reagent, or both, to the influence of a magnetic field. Hence, by measuring the response to the magnetic field of the magnetically responsive reagent, or that of the mobile solid phase reagent, the presence or amount of analyte contained in a test sample can accurately be determined. The invention utilizes various devices to carry out the assay methods described.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: September 25, 2001
    Assignee: Abbott Laboratories
    Inventors: Thomas E. Rohr, Tuan A. Elstrom, Lawrence V. Howard, Eric B. Shain
  • Patent number: 6032059
    Abstract: The present invention relates to a device for the sampling of blood or other body fluids which includes means for the direct measurement of the analyte of interest within the fluid. Also disclosed is a `closed-loop` device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: February 29, 2000
    Assignee: Abbott Laboratories
    Inventors: Timothy P. Henning, Eric B. Shain, Gamal Khalil, Tuan A. Elstrom
  • Patent number: 6014577
    Abstract: The present invention relates to a device for the sampling of blood or other body fluids which includes means for the direct measurement of the analyte of interest within the fluid. Also disclosed is a `closed-loop` device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.
    Type: Grant
    Filed: November 20, 1997
    Date of Patent: January 11, 2000
    Assignee: Abbot Laboratories
    Inventors: Timothy P. Henning, Eric B. Shain, Gamal Khalil, Tuan A. Elstrom
  • Patent number: 6009343
    Abstract: The present disclosure provides the use of vacuum to enhance the transdermal transport of fluids in sampling methods for the detection of analytes in a patient's blood.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: December 28, 1999
    Assignee: Abbott Laboratories
    Inventors: Eric B. Shain, Tuan A. Elstrom, Thomas G. Schapira, Timothy P. Henning
  • Patent number: 5998224
    Abstract: Assay methods utilizing the response of a magnetically responsive reagent to the influence of a magnetic field to qualitatively or quantitatively measure binding between specific binding pair members. According to the invention, the presence of an analyte mediates whether or not the magnetically responsive reagent binds to a mobile solid phase reagent. The extent of binding will modulate the response of the magnetically responsive reagent or that of the mobile solid phase reagent, or both, to the influence of a magnetic field. Hence, by measuring the response to the magnetic field of the magnetically responsive reagent, or that of the mobile solid phase reagent, the presence or amount of analyte contained in a test sample can accurately be determined. The invention utilizes various devices to carry out the assay methods described.
    Type: Grant
    Filed: May 16, 1997
    Date of Patent: December 7, 1999
    Assignee: Abbott Laboratories
    Inventors: Thomas E. Rohr, Tuan A. Elstrom, Lawrence V. Howard, Eric B. Shain
  • Patent number: 5913833
    Abstract: This invention provides a method and apparatus for disrupting the outermost layer of skin, the stratum corneum, to provide access to biological fluid, which can then be used to determine the concentration of glucose in blood. The invention can be used to extract interstitial fluid, blood, and mixtures of interstitial fluid and blood from the body of a human or an animal.The method comprises the steps of (1) attaching a receptacle for collecting biological fluid to the surface of the skin of a patient, (2) introducing an oscillation concentrator attached to an oscillation element into the receptacle, (3) positioning the oscillation concentrator at a desired distance from the surface of the skin, (4) activating the oscillation element to transversely oscillate the attached oscillation concentrator, (5) collecting the biological fluid after a specific period of time, and (6) analyzing the biological fluid for the presence of an analyte.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: June 22, 1999
    Assignee: Abbott Laboratories
    Inventors: Tuan A. Elstrom, Eric B. Shain
  • Patent number: 5895362
    Abstract: A process for the sampling of extracellular fluid across the skin of an animal involves establishing an ultrasonic standing wave across the skin and collecting fluid transudate. Sampling can be enhanced by combining the use of ultrasound with the application of a partial vacuum to the surface of the skin. An apparatus includes an ultrasonic transducer, a reflector and an absorbent material for collecting transudate. The apparatus can further include a pressure component for reducing hydrostatic pressure on the skin surface.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: April 20, 1999
    Assignee: Abbott Laboratories
    Inventors: Tuan A. Elstrom, Eric B. Shain, Timothy P. Henning