Patents by Inventor Tuan A. Elstrom
Tuan A. Elstrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10184907Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.Type: GrantFiled: October 8, 2015Date of Patent: January 22, 2019Assignee: T2 Biosystems, Inc.Inventors: Thomas Jay Lowery, Jr., James Joseph Koziarz, Douglas Adam Levinson, David A. Berry, Tuan A. Elstrom, Sonia Kumar, Mark John Audeh
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Publication number: 20160033494Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.Type: ApplicationFiled: October 8, 2015Publication date: February 4, 2016Inventors: Thomas Jay LOWERY, JR., James Joseph KOZIARZ, Douglas Adam LEVINSON, David A. BERRY, Tuan A. ELSTROM, Sonia KUMAR, Mark John AUDEH
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Patent number: 8870810Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.Type: GrantFiled: September 13, 2012Date of Patent: October 28, 2014Assignee: Echo Therapeutics, Inc.Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F Warner, Tuan A Elstrom
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Publication number: 20130267471Abstract: This invention relates to a topical gel drug product preparation containing a composition comprising an isolated polypeptide having a carboxy-terminal amino acid sequence of an alpha connexin (ACT peptide), peptide stabilizers, excipients, buffering agents, and the like. A formulation and preparation steps are disclosed for the manufacturing of a stable, elegant, and pourable topical gel. The resulting formulation possesses long term stability suitable for aesthetic as well as therapeutic applications including the prevention of scaring and accelerated healing of wounds. Methods for treatment of chronic wounds, including chronic ulcers, are also provided.Type: ApplicationFiled: March 15, 2013Publication date: October 10, 2013Inventors: Gautam Ghatnekar, Tuan Elstrom
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Publication number: 20130177628Abstract: Provided herein are compositions and methods for use in promoting wound healing and tissue regeneration following tissue injury in a subject.Type: ApplicationFiled: December 14, 2012Publication date: July 11, 2013Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENTInventors: Gautam GHATNEKAR, Tuan Elstrom
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Publication number: 20130035566Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.Type: ApplicationFiled: September 13, 2012Publication date: February 7, 2013Applicant: ECHO THERAPEUTICS, INC.Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F. Warner, Tuan A. Elstrom
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Patent number: 8287483Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area of the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.Type: GrantFiled: March 5, 2004Date of Patent: October 16, 2012Assignee: Echo Therapeutics, Inc.Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F. Warner, Tuan A. Elstrom
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Publication number: 20110275985Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.Type: ApplicationFiled: July 2, 2009Publication date: November 10, 2011Applicant: T2 Biosystems, Inc.Inventors: Thomas Jay Lowery, JR., James J. Koziarz, Douglas A. Levinson, David A. Berry, Tuan A. Elstrom, Sonia Kumar, Mark John Audeh
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Publication number: 20110020785Abstract: This invention relates generally to a process for producing machine readable contextual diagnostic information and use of contextual diagnostic information for generating tangible and useful results. The process provides the highest level of integration of diagnostic information collected in a distributed or centralized system comprising diagnostic devices and a global computer network. More particularly, in certain embodiments, contextual diagnostic information are used in specific diagnostic related applications and business models including ecommerce.Type: ApplicationFiled: July 28, 2008Publication date: January 27, 2011Applicant: T2 Biosystems, Inc.Inventors: Thomas J. Lowery, JR., Tuan A. Elstrom, Douglas A. Levinson, James J. Koziarz
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Patent number: 7066884Abstract: A system, method, and device for non-invasive body fluid sampling is provided. According to one embodiment of the present invention, the system includes a controller that controls the generation of ultrasound; an ultrasonic applicator that applies the ultrasound to an area of biological membrane; a receiver that contacts the area of biological membrane and receives body fluid through and out of the area of biological membrane; and a meter that interacts with the receiver and detects the presence of at least one analyte in the body fluid in the receiver. The receiver may include a membrane and a medium, such as a hydrogel, a fluid, or a liquid, that is contained in the membrane.Type: GrantFiled: March 16, 2001Date of Patent: June 27, 2006Assignee: Sontra Medical, Inc.Inventors: Linda Custer, Tuan A. Elstrom, Scott C. Kellogg, Joseph Kost, Nicholas F. Warner
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Patent number: 6887239Abstract: The invention provides a convenient and non-invasive means to prepare cells, tissues, and organs for electrical transmission and reception. In an embodiment of the invention, a control method comprises the use of at least one skin electrode, as a reference electrode, and an electrical sensor to measure periodically or continuously the skin's electrical conductance at the site of preparation. The dynamic change in the conductance through the skin is measured while the ultrasound is applied. Signal processing is performed on the measurement and the level of skin impedance change is controlled by performing a mathematical analysis and using the results of such analysis to control the application of ultrasonic energy. A desired level of skin impedance can be set at a predetermined value or based on a chosen level of skin integrity, subject's sensation of discomfort, or duration of the ultrasound application.Type: GrantFiled: April 11, 2003Date of Patent: May 3, 2005Assignee: Sontra Medical Inc.Inventors: Tuan A. Elstrom, Scott Kellogg, Joseph Kost, Samir S. Mitragotri, Nicolas F. Warner, Steve DiMatteo
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Publication number: 20050049474Abstract: The invention provides a convenient and non-invasive means to prepare cells, tissues, and organs for electrical transmission and reception. In an embodiment of the invention, a control method comprises the use of at least one skin electrode, as a reference electrode, and an electrical sensor to measure periodically or continuously the skin's electrical conductance at the site of preparation. The dynamic change in the conductance through the skin is measured while the ultrasound is applied. Signal processing is performed on the measurement and the level of skin impedance change is controlled by performing a mathematical analysis and using the results of such analysis to control the application of ultrasonic energy. A desired level of skin impedance can be set at a predetermined value or based on a chosen level of skin integrity, subject's sensation of discomfort, or duration of the ultrasound application.Type: ApplicationFiled: September 28, 2004Publication date: March 3, 2005Applicant: Sontra Medical, IncInventors: Scott Kellogg, Tuan Elstrom, Joseph Kost, Samir Mitragotri, Nicolas Warner, Steve Dimatteo
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Publication number: 20040236268Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area of the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.Type: ApplicationFiled: March 5, 2004Publication date: November 25, 2004Applicant: Sontra Medical, Inc.Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F. Warner, Tuan A. Elstrom
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Publication number: 20040171980Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area of the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.Type: ApplicationFiled: March 5, 2004Publication date: September 2, 2004Applicant: Sontra Medical, Inc.Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F. Warner, Tuan A. Elstrom
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Publication number: 20040039418Abstract: The invention provides a convenient and non-invasive means to prepare cells, tissues, and organs for electrical transmission and reception. In an embodiment of the invention, a control method comprises the use of at least one skin electrode, as a reference electrode, and an electrical sensor to measure periodically or continuously the skin's electrical conductance at the site of preparation. The dynamic change in the conductance through the skin is measured while the ultrasound is applied. Signal processing is performed on the measurement and the level of skin impedance change is controlled by performing a mathematical analysis and using the results of such analysis to control the application of ultrasonic energy. A desired level of skin impedance can be set at a predetermined value or based on a chosen level of skin integrity, subject's sensation of discomfort, or duration of the ultrasound application.Type: ApplicationFiled: April 11, 2003Publication date: February 26, 2004Inventors: Tuan A. Elstrom, Scott Kellogg, Joseph Kost, Samir S. Mitragotri, Nicolas F. Warner, Steve DiMatteo
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Publication number: 20030100846Abstract: A system, method, and device for non-invasive body fluid sampling is provided. According to one embodiment of the present invention, the system includes a controller that controls the generation of ultrasound; an ultrasonic applicator that applies the ultrasound to an area of biological membrane; a receiver that contacts the area of biological membrane and receives body fluid through and out of the area of biological membrane; and a meter that interacts with the receiver and detects the presence of at least one analyte in the body fluid in the receiver. The receiver may include a membrane and a medium, such as a hydrogel, a fluid, or a liquid, that is contained in the membrane.Type: ApplicationFiled: March 11, 2002Publication date: May 29, 2003Inventors: Linda Custer, Tuan A. Elstrom, Scott C. Kellogg, Joseph Kost, Nicholas F. Warner
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Patent number: 6294342Abstract: Assay methods utilizing the response of a magnetically responsive reagent to the influence of a magnetic field to qualitatively or quantitatively measure binding between specific binding pair members. According to the invention, the presence of an analyte mediates whether or not the magnetically responsive reagent binds to a mobile solid phase reagent. The extent of binding will modulate the response of the magnetically responsive reagent or that of the mobile solid phase reagent, or both, to the influence of a magnetic field. Hence, by measuring the response to the magnetic field of the magnetically responsive reagent, or that of the mobile solid phase reagent, the presence or amount of analyte contained in a test sample can accurately be determined. The invention utilizes various devices to carry out the assay methods described.Type: GrantFiled: September 29, 1999Date of Patent: September 25, 2001Assignee: Abbott LaboratoriesInventors: Thomas E. Rohr, Tuan A. Elstrom, Lawrence V. Howard, Eric B. Shain
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Patent number: 6032059Abstract: The present invention relates to a device for the sampling of blood or other body fluids which includes means for the direct measurement of the analyte of interest within the fluid. Also disclosed is a `closed-loop` device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.Type: GrantFiled: July 22, 1997Date of Patent: February 29, 2000Assignee: Abbott LaboratoriesInventors: Timothy P. Henning, Eric B. Shain, Gamal Khalil, Tuan A. Elstrom
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Patent number: 6014577Abstract: The present invention relates to a device for the sampling of blood or other body fluids which includes means for the direct measurement of the analyte of interest within the fluid. Also disclosed is a `closed-loop` device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.Type: GrantFiled: November 20, 1997Date of Patent: January 11, 2000Assignee: Abbot LaboratoriesInventors: Timothy P. Henning, Eric B. Shain, Gamal Khalil, Tuan A. Elstrom
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Patent number: 6009343Abstract: The present disclosure provides the use of vacuum to enhance the transdermal transport of fluids in sampling methods for the detection of analytes in a patient's blood.Type: GrantFiled: February 23, 1996Date of Patent: December 28, 1999Assignee: Abbott LaboratoriesInventors: Eric B. Shain, Tuan A. Elstrom, Thomas G. Schapira, Timothy P. Henning