Abstract: A replacement heart valve assembly where the valve is loaded into the catheter distally, and separately from the stent. The valve has a locking member and the stent has a locking channel. Once in the expanded position, the valve is pulled towards the stent until the locking member is engaged with the locking channel.

Abstract: A packaging system for storing a deployable medical device within a sterilized environment includes a sealed container; a tray disposed within the sealed container; a catheter assembly comprising at least one sheath; a deployable medical device engaged with the catheter assembly; and a sterilizing fluid. The tray comprises a first chamber; a second chamber in fluid communication therewith; and at least a third chamber between the first and second chambers, and in fluid communication with at least the first chamber. The deployable medical device is disposed within the tray in a storage configuration, in which the deployable medical device is disposed within the first chamber in a partially deployed state distally from a distal end of the catheter and the catheter assembly spans between the first chamber and the second chamber. The sterilizing fluid contacts at least a part of the deployable medical device in the storage configuration.

Abstract: A heart valve assembly for endovascular heart repair, where the valve is in an inverted position relative to the stent to reduce the diameter of the device for delivery and deployment. The heart valve assembly has an expandable stent and a valve. The valve having a proximal end and a distal end, the proximal end of the valve connected to the distal end of the expandable stent, wherein the valve extends distally from the distal end of the expandable stent.

Abstract: A replacement heart valve assembly where the valve is loaded into the catheter distally, and separately from the stent. The valve has a locking member and the stent has a locking channel. Once in the expanded position, the valve is pulled towards the stent until the locking member is engaged with the locking channel.

Abstract: A valve for endovascular heart valve repair that provides improved sealing of the valve against the native wall. The valve assembly has a sealing region at a distal end of the valve. The sealing region having a delivery position and a sealing position, wherein in the delivery position, the sealing region has a first length, and in the sealing position, the sealing region has a second length less than the first length and a thickness in the sealing position is greater in the sealing position than in the delivery position.

Abstract: In an example embodiment, data in a multi-tenant database is organized as a graph representing the relationships among all documents and tenants. Specifically, each document is represented as a node in the graph and each tenant also is represented as a node. The relationships between the documents themselves, or between a document and a graph, are then represented as edges in the graph. A list of tenants whose data should be marked for deletion (e.g., former customers who no longer have a relationship with the entity maintaining the database) may be maintained. Periodically (e.g., once a week), this list of tenants and the relationship graph are fed as input into a graph search algorithm that generates smaller relationship graphs comprised only of documents associated with those accounts.

Abstract: A valve for endovascular heart valve repair that provides improved sealing of the valve against the native wall. The valve assembly has a sealing region at a distal end of the valve. The sealing region having a delivery position and a sealing position, wherein in the delivery position, the sealing region has a first length, and in the sealing position, the sealing region has a second length less than the first length and a thickness in the sealing position is greater in the sealing position than in the delivery position.

Abstract: A replacement heart valve assembly where the valve is loaded into the catheter distally, and separately from the stent. The valve has a locking member and the stent has a locking channel. Once in the expanded position, the valve is pulled towards the stent until the locking member is engaged with the locking channel.

Abstract: A packaging system for storing a deployable medical device within a sterilized environment includes a sealed container; a tray disposed within the sealed container; a catheter assembly comprising at least one sheath; a deployable medical device engaged with the catheter assembly; and a sterilizing fluid. The tray comprises a first chamber; a second chamber in fluid communication therewith; and at least a third chamber between the first and second chambers, and in fluid communication with at least the first chamber. The deployable medical device is disposed within the tray in a storage configuration, in which the deployable medical device is disposed within the first chamber in a partially deployed state distally from a distal end of the catheter and the catheter assembly spans between the first chamber and the second chamber. The sterilizing fluid contacts at least a part of the deployable medical device in the storage configuration.

Abstract: A sterilized packaging system for a deployable medical device comprises a sealed container with a tray disposed within the sealed container. The tray comprises a first chamber at a proximal end of the tray and at least a deployable medical device is disposed within the first chamber in a storage configuration, wherein the deployable medical device is engaged with the catheter and positioned in a partially deployed state distally from the distal end of a catheter. A sterilizing fluid is disposed within at least the first chamber.

Abstract: Disclosed embodiments and methods provide solutions for coupling and decoupling of a delivery device from a stented prosthetic heart valve with one or more release mechanisms. In situations when one or more sutures get tangled or caught upon attempted retraction of the delivery device and sutures after deployment of the stented prosthetic heart valve, a secondary release mechanism can be provided to sever the suture(s) or release the suture(s) from the delivery device. Exemplary secondary release mechanisms include high resistance inserts, cutters and balloon expandable devices. Methods of releasing the sutures from the delivery device or severing the suture(s) are also disclosed.

Abstract: An apparatus includes a syringe housing and a plunger slidably received within the syringe housing. A plunger magnet is secured to the plunger. A potentiometer housing is fixed to the syringe housing and includes a potentiometer disposed therein. A wiper magnet is also disposed within the potentiometer housing. Movement of the plunger magnet causes a corresponding movement of the wiper magnet.

Abstract: A sterilized packaging system for a deployable medical device comprises a sealed container with a tray disposed within the sealed container. The tray comprises a first chamber at a proximal end of the tray and at least a deployable medical device is disposed within the first chamber in a storage configuration, wherein the deployable medical device is engaged with the catheter and positioned in a partially deployed state distally from the distal end of a catheter. A sterilizing fluid is disposed within at least the first chamber.

Abstract: Disclosed embodiments and methods provide solutions for coupling and decoupling of a delivery device from a stented prosthetic heart valve with one or more release mechanisms. In situations when one or more sutures get tangled or caught upon attempted retraction of the delivery device and sutures after deployment of the stented prosthetic heart valve, a secondary release mechanism can be provided to sever the suture(s) or release the suture(s) from the delivery device. Exemplary secondary release mechanisms include high resistance inserts, cutters and balloon expandable devices. Methods of releasing the sutures from the delivery device or severing the suture(s) are also disclosed.

Abstract: A method includes establishing an initial resistive force on a contrast fluid in a contrast delivery modulation component and injecting the contrast fluid into the patient with an injection syringe fluidly connected to the injection catheter and the contrast fluid inlet port of the contrast delivery modulation component. A contrast delivery measurement component is used to assess a total volume of the contrast fluid injected into the patient and a resistive force imparted upon the contrast fluid in the chamber.

Abstract: An apparatus includes a syringe housing and a plunger slidably received within the syringe housing. A plunger magnet is secured to the plunger. A potentiometer housing is fixed to the syringe housing and includes a potentiometer disposed therein. A wiper magnet is also disposed within the potentiometer housing. Movement of the plunger magnet causes a corresponding movement of the wiper magnet.

Abstract: Vascular access systems for performing hemodialysis are disclosed. The vascular access system contemplates a catheter section adapted for insertion into a vein and a graft section adapted for attachment to an artery. The catheter section may have metal or polymer wall reinforcements that allow the use of thin-walled, small outer diameter conduits for the vascular access system. One or more of the adhered, embedded or bonded conduit reinforcement structures may be removable without significant damage to the conduit sections to facilitate attachment of the sections, or to a connector between the sections. Various self-sealing materials are provided for use in the vascular access system, as well as temporary access sites and flow control/sensor systems.

Abstract: A host bus adapter (“HBA”) is provided with a programmable trace logic that can be enabled or disabled by firmware running on the HBA and if enabled can receive trace information from at least one processor, which is stored in a local memory buffer controlled by a local memory interface. A receive and transmit path processor data is traced and stored in the local memory buffer. The trace logic includes an arbitration module that receives trace data from plural sources and the trace data is stored in a first in first out based buffer before being sent to a direct memory access arbiter module and then to an external memory. Trace data as stored in the external memory includes a trace data source identity value, and a time stamp value indicating when data was collected.

Abstract: Methods and devices are disclosed for connecting implantable body fluid conduits, such as catheters and grafts for AV shunts. A connector with thin connector walls at the lumen openings provides a connecting lumen that is close to flush with the lumens of the attached conduits. A tapered, smooth walled connector lumen allows connection of conduits with different internal diameters while preserving laminar flow in the transition between different conduit diameters. Rounding of the connector edges at the lumen openings further reduce disturbances in flow.

Abstract: A method for treating an occlusion in a coronary artery of a patient includes percutaneously advancing an occlusion treatment tool (such as an angioplasty balloon or stent delivery device) through the vasculature of the patient and into a coronary artery to a site of the occlusion. Following the treatment of the occlusion, a therapeutic agent is admitted into the first coronary artery. The therapeutic agent is selected to treat microvasculature obstructions at a target cardiac tissue site distal to the site of the occlusion.