Abstract: Systems and methods are provided for delivering closed-loop or partially closed-loop baroreflex activation therapy (BAT) to treat conditions associated with autonomic dysfunction. A pulse generator delivers stimulation while physiological data, such as ECG, heart rate variability, bioimpedance, and physical activity levels, is collected from one or more sensors. The data is analyzed to assess autonomic nervous system activity, and stimulation parameters are dynamically adjusted in response. In some embodiments, adjustments are made on a beat-to-beat basis using ECG input. Artificial intelligence algorithms may be used to predict patient-specific responses, optimize therapy, and evaluate effectiveness. The method may further include integrating patient-reported symptoms, wirelessly transmitting data, or adjusting stimulation duty cycle based on time of day. The system may further incorporate patient-reported symptoms, a clinician dashboard for remote monitoring, and a multi-channel lead.

Abstract: The present disclosure provides a method for context-aware circuit design for a wearable device. The method includes determining a peak power requirement at a selected operating voltage for a rectifier circuit to be coupled between an antenna and system circuitry of the wearable device, the peak power requirement is based on a distance (d) between the wearable device and a power transmitter; determining a real value of at least on real circuit component of the rectifier circuit based on the peak power requirement; and determining a reactive value of at least one reactive component of the rectifier circuit based on the peak power requirement.

Abstract: The present disclosure provides biosymbiotic systems and devices for continuous monitoring of electrophysiological biosignals. The systems and devices described herein include carbon-doped filament deposition modeling (FDM) printed dry electrodes that overcome impedance degradation by seamless integration into textile and wearable biosymbiotic platforms, allowing for high fidelity operation over indefinite timescales. The systems and devices also include at-distance wirelessly powered wearable electronics. The systems and devices described herein can be used to monitor ECG/EIP during work, activity, and sleep and BioZ recordings documenting gains in forearm training over weeks.

Abstract: Three-dimensionally (3D) printed, wearable, electronic sensing articles and methods of manufacture are disclosed.