Patents by Inventor Tudor Moldoveanu

Tudor Moldoveanu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variant Calpastatins and Variant Calpains for Modulating the Activity or Stability of Calpain
    Publication number: 20120240246
    Abstract: The present invention features stabilized/destabilized variant calpastatin proteins and peptides that modulate the stability/activity of calpain for use in analyzing the pathophysiology of diseases associated with calpain activity, facilitating muscle growth and in improving meat tenderization.
    Type: Application
    Filed: November 17, 2010
    Publication date: September 20, 2012
    Applicant: St. Jude Children's Research Hospital
    Inventor: Tudor Moldoveanu
  • Methods of determining polypeptide structure and function
    Patent number: 7236891
    Abstract: The present invention provides methods for determining the structure and/or function of one or more domains of a cation-dependent (and preferably calcium-dependent) polypeptide (particularly a calcium-dependent enzyme, which may be a protease such as calpain) in the presence of one or more cations. The invention further provides methods for identifying a ligand having the ability to bind to one or more ligand-binding domains (LBDs) of a cation-dependent (and preferably calcium-dependent) polypeptide, and ligands identified by these methods. The invention also provides methods of treating or preventing physical disorders in animals using these ligands.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: June 26, 2007
    Assignee: Queen's University at Kingston
    Inventors: Peter L. Davies, John S. Elce, Christopher Hosfield, Zongchao Jia, Tudor Moldoveanu
  • Methods of determining polypeptide structure and function
    Publication number: 20030017984
    Abstract: The present invention provides methods for determining the structure and/or function of one or more domains of a cation-dependent (and preferably calcium-dependent) polypeptide (particularly a calcium-dependent enzyme, which may be a protease such as calpain) in the presence of one or more cations. The invention further provides methods for identifying a ligand having the ability to bind to one or more ligand-binding domains (LBDs) of a cation-dependent (and preferably calcium-dependent) polypeptide, and ligands identified by these methods. The invention also provides methods of treating or preventing physical disorders in animals using these ligands.
    Type: Application
    Filed: May 30, 2002
    Publication date: January 23, 2003
    Inventors: Peter L. Davies, John S. Elce, Christopher Hosfield, Zongchao Jia, Tudor Moldoveanu